US10745678B1ActiveUtility

Nucleic acid-guided nucleases

Assignee: INSCRIPTA INCPriority: Dec 13, 2019Filed: May 6, 2020Granted: Aug 18, 2020

Est. expiryDec 13, 2039(~13.4 yrs left)· nominal 20-yr term from priority

Inventors:Juhan Kim Benjamin Mijts Aamir Mir Andrew Garst Kyle Seamon

C12N 2310/20C12N 15/81C12N 15/74C12N 15/70C12N 15/102C12N 9/22C12N 9/222C12N 15/905C12N 2310/531C12N 15/85C12N 15/907

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Abstract

The present disclosure provides novel RNA-guided enzymes for making rational and direct edits to the genome of live cells.

Claims

exact text as granted — not AI-modified

We claim: 
     
       1. A coding sequence for a nucleic acid-guided nuclease comprising nucleic acid sequence SEQ ID No. 19. 
     
     
       2. The coding sequence for the nucleic acid-guided nuclease of  claim 1 , wherein a compatible guide RNA to the nucleic-acid-guided nuclease has an optimal crRNA variable loop comprising UGUU.

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