Synthetic molecule constructs

Abstract

Synthetic molecule construct of the structure F-S1-S2-L where F-S1 is an aminoalkylglycoside and S2-L is a dicarboxylated, e.g. adipylated, phosphatidylethanolamide are disclosed. The two terminal sugars of the aminoalkylglycoside (Galα1-3Galβ-) are the two terminal sugars of the Galili antigen.

The invention claimed is: 
     
       1. A construct of the structure F-S 1 -S 2 -L where: F—S 1  is an aminoalkylglycoside comprising the terminal sugars Galα1-3Galβ and S 1  is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl or 5-aminopentyl; S 2  is —CO(CH 2 ) 2 CO—, —CO(CH 2 ) 3 CO—, —CO(CH 2 ) 4 CO— or —CO(CH 2 ) 5 CO—; and L is phosphatidylethanolamine. 
     
     
       2. The construct of  claim 1  where the aminoalkylglycoside is an aminoalkyltrisaccharide. 
     
     
       3. The construct of  claim 2  where S 1  is 3-aminopropyl. 
     
     
       4. The construct of  claim 3  where S 2  is —CO(CH 2 ) 4 CO—. 
     
     
       5. The construct of  claim 4  where L is dioleoylphosphatidylethanolamine.