Sialic acid analogs

Abstract

The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.

What is claimed is: 
     
       1. A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
     
     
       2. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       3. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       4. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       5. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       6. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       7. The compound of  claim 1 , wherein the compound is: 
       
         
           
           
               
               
           
         
       
     
     
       8. A pharmaceutical composition comprising a compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier. 
       
     
     
       9. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       10. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       11. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       12. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       13. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       14. The pharmaceutical composition of  claim 8 , comprising the compound: 
       
         
           
           
               
               
           
         
       
     
     
       15. A sustained release pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt or solvate thereof, wherein:
 a) the release of the compound is over a period of about 4 hours to about 24 hours; and/or 
 b) the pharmacological effect from the compound lasts about four hours to about 24 hours upon administration of the composition. 
 
     
     
       16. A sustained release pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt or solvate thereof,
 wherein the composition, upon administration, provides a therapeutically effective amount of the compound for about 4 hours to about 24 hours. 
 
     
     
       17. A method for treating a sialic acid deficiency in a patient in need thereof comprising administering an effective amount of a compound of  claim 1 , or a pharmaceutically acceptable salt or solvate thereof. 
     
     
       18. A method for treating a sialic acid deficiency in a patient in need thereof comprising administering a compound of  claim 1 , or a pharmaceutically acceptable salt or solvate thereof wherein upon administration, the compound, or a pharmaceutically acceptable salt or solvate thereof, continuously provides a therapeutically effective amount of sialic acid for about 4 hours to about 24 hours. 
     
     
       19. The method of  claim 17 , wherein the sialic acid deficiency is myopathy caused by sialic acid deficiency. 
     
     
       20. The method of  claim 19 , wherein the myopathy caused by sialic acid deficiency is Hereditary Inclusion Body Myopathy (HIBM), Nonaka myopathy, or Distal Myopathy with Rimmed Vacuoles (DMRV).