US10918891B2ActiveUtilityA1

Cosmetic treatment method for the skin

32
Assignee: SYNTIVIAPriority: Jul 22, 2016Filed: Jul 21, 2017Granted: Feb 16, 2021
Est. expiryJul 22, 2036(~10 yrs left)· nominal 20-yr term from priority
Inventors:Philippe Bedos
A61K 2800/522A61K 2800/28A61Q 17/04A61K 8/64A61K 8/4926A61Q 19/08A61K 8/67
32
PatentIndex Score
0
Cited by
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References
17
Claims

Abstract

Disclosed is a cosmetic treatment method for the skin, in particular for preventing and/or repairing the signs of skin ageing, that includes administering, and in particular applying topically to the skin, a composition containing, in a cosmetically acceptable vehicle, a compound of general formula (I): (formula I) in which R1, R2, R3, R4, R5, R6, R7 and R8, which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, at least one group from R1, R2, R3, R4, R5, R6, R7 and R8 not representing a hydrogen atom or a halogen atom, Z represents a covalent bond or a spacer arm, or one of the salts of same.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. Method for cosmetic treatment of the skin of an individual, comprising the administration, to said individual, of a composition containing, in a cosmetically acceptable vehicle, a compound having the general formula (I): 
       
         
           
           
               
               
           
         
         wherein: 
         R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8 , which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, 
         at least one group out of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8  not representing a hydrogen atom or a halogen atom, 
         Z represents a covalent bond or a spacer arm, 
         or one of the salts thereof. 
       
     
     
       2. Method according to  claim 1 , wherein the administration of said composition to said individual is carried out by applying said composition topically onto the skin of said individual. 
     
     
       3. Method according to  claim 1 , wherein Z represents a spacer arm carrying an amide function. 
     
     
       4. Method according to  claim 3 , wherein Z represents a group having the formula (II): 
       
         
           
           
               
               
           
         
         wherein Y represents a covalent bond or a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical. 
       
     
     
       5. Method according to  claim 4 , wherein at least one out of R 3 , R 4 , R 5 , R 6  and R 8  represents a hydroxyl group, and Y represents a covalent bond or a C2-C4 alkenyl radical. 
     
     
       6. Method according to  claim 1 , wherein said compound of general formula (I) has the formula (I′): 
       
         
           
           
               
               
           
         
         wherein 
         R 1 , R 2 , R 3 , R 4 , R 5  and R 7 , which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, 
         at least one group out of R 1 , R 2 , R 3 , R 4  and R 5  representing a hydroxyl group, 
         and Y represents a covalent bond or a C2-C4 alkenyl radical. 
       
     
     
       7. Method according to  claim 6 , wherein, in the general formula (I′), at least R 1  and R 2  each represent a hydrogen atom. 
     
     
       8. Method according to  claim 6 , wherein, in the formula (I′), R 3  does not represent a hydrogen atom and R 1  and R 5  each represent a hydrogen atom. 
     
     
       9. Method according to  claim 6 , wherein, in the formula (I′), at least one substituent out of R 2 , R 3  and R 4  represents a hydroxyl group. 
     
     
       10. Method according to  claim 1 , wherein said compound of general formula (I) has the formula (I″): 
       
         
           
           
               
               
           
         
         wherein 
         R 3 , R 4 , R 5  each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, 
         at least one first group out of R 3 , R 4  and R 5  representing a hydroxyl group and at least one second group out of R 3 , R 4  and R 5  representing a hydroxyl group or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C4 hydrocarbon radical, 
         R 7  represents a linear or branched, saturated or unsaturated, C1-C4 hydrocarbon radical, 
         and Y represents a covalent bond or a C2-C4 alkenyl radical. 
       
     
     
       11. Method according to  claim 10 , wherein, in the formula (I″), R 3  does not represent a hydrogen atom and R 5  represents a hydrogen atom. 
     
     
       12. Method according to  claim 10 , wherein, in the formula (I″), at least one substituent out of R 3  and R 4  represents a hydroxyl group. 
     
     
       13. Method according to  claim 1 , wherein said compound of general formula (I) has the formula (I′″): 
       
         
           
           
               
               
           
         
         wherein 
         R 3  represents a hydroxyl group, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, 
         R 4  represents a hydrogen atom or a hydroxyl group,
 R 7  represents a linear or branched, saturated or unsaturated, C1-C4 hydrocarbon radical, 
 
         and Y represents a covalent bond or a C2-C4 alkenyl radical. 
       
     
     
       14. Method according to  claim 13 , wherein, in the formula (I′″), R 4  represents a hydroxyl group. 
     
     
       15. Method according to  claim 1 , wherein said compound of general formula (I) has the formula (Ia): 
       
         
           
           
               
               
           
         
       
     
     
       16. Method according to  claim 1 , wherein said compound of general formula (I) has the formula (Ic): 
       
         
           
           
               
               
           
         
       
     
     
       17. Cosmetic composition, containing a compound having the general formula (I), or one of the salts thereof, with the exclusion of the following compounds:
 3-(2,4-dihydroxyphenyl)-N-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-acrylamide 
 3-(3,5-dihydroxyphenyl)-N-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-acrylamide 
 3-(2,6-dihydroxyphenyl)-N-(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-acrylamide, 
 in a cosmetically acceptable vehicle: 
 
       
         
           
           
               
               
           
         
         wherein: 
         R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8 , which may be identical or different, each represent a hydrogen atom, a halogen atom, a hydroxyl group, a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, or an —OR′ radical in which R′ represents a linear or branched, saturated or unsaturated, C1-C16 hydrocarbon radical, 
         at least one group out of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7  and R 8  not representing a hydrogen atom or a halogen atom, 
         Z represents a covalent bond or a spacer arm.

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