Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity

Abstract

Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

What is claimed is: 
     
       1. A compound represented by Formula IB1 or a pharmaceutically acceptable salt thereof 
       
         
           
           
               
               
           
         
         wherein n is 1; 
         Q is absent; 
         R 1  is hydrogen or halo; and 
         R 7  is phenyl substituted by alkoxy having from 6 to 10 carbon atoms or phenoxy. 
       
     
     
       2. The compound or salt of  claim 1 , wherein the compound is selected from the group consisting of:
 N-[3-(Hexyloxy)benzyl]quinazolin-4-amine, 
 N-[3-(Decyloxy)benzyl]quinazolin-4-amine, 
 N-[4-(Decyloxy)benzyl]quinazolin-4-amine, 
 N-[4-(Hexyloxy)benzyl]quinazolin-4-amine. 
 
     
     
       3. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       4. The compound or salt of  claim 1 , wherein the compound is N-(3-Phenoxybenzyl)quinazolin-4-amine. 
     
     
       5. A pharmaceutical composition comprising an effective amount of the compound or pharmaceutically acceptable salt of  claim 4  and a pharmaceutically acceptable carrier. 
     
     
       6. A method of inhibiting a fungus ex vivo, comprising contacting a surface or the fungus with the compound or pharmaceutically acceptable salt of  claim 1 . 
     
     
       7. A method of inhibiting a fungus ex vivo, comprising contacting a surface or the fungus with the compound or pharmaceutically acceptable salt of  claim 4 .