Methods of using 1-O-acetylbritannilatone spiro aryl isoxazoline compounds

Abstract

A method of inhibiting leukotriene include: administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject,R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.

What is claimed is: 
     
       1. A method of inhibiting leukotriene comprising:
 administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject, 
 
       
         
           
           
               
               
           
         
         wherein R 1  is OH or OAc; X is C or N; and R 2  is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO 2 , or halogen, provided that when X is N, R 2  is nil. 
       
     
     
       2. The method of  claim 1 , wherein X is C and R 2  is H, F, Cl, Br, CN, CH 3 , OCH 3 , NO 2  or OH.