Patch

Abstract

A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

The invention claimed is: 
     
       1. A patch comprising a backing layer and an adhesive layer, wherein
 the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, 
 a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base in the adhesive layer is 8.0:2.0 to 1.9:8.1, and 
 the content of the silicone-based adhesive base in the adhesive layer is 1 to 47% by mass relative to the total mass of the adhesive layer. 
 
     
     
       2. The patch according to  claim 1 , wherein the content of the butorphanol and/or pharmaceutically acceptable salt thereof in the adhesive layer is 0.2 to 2.0 mg/cm 2  per unit area of the adhesive layer in terms of the mass of a tartaric acid addition salt of butorphanol. 
     
     
       3. The patch according to  claim 1 , wherein the content of the butorphanol and/or pharmaceutically acceptable salt thereof in the adhesive layer in terms of the mass of a tartaric acid addition salt of butorphanol is 3 to 20% by mass relative to the total mass of the adhesive layer. 
     
     
       4. The patch according to  claim 1 , wherein the adhesive layer further contains at least one selected from the group consisting of tackifiers and plasticizers.