P
US11213527B2ActiveUtilityPatentIndex 53

Inhibitory effect of low molecular weight compound on cancer and fibrosis

Assignee: NAT UNIV CORP TOTTORI UNIVPriority: Mar 28, 2014Filed: Mar 25, 2015Granted: Jan 4, 2022
Est. expiryMar 28, 2034(~7.7 yrs left)· nominal 20-yr term from priority
Inventors:SHIOTA GOSHIITABA NORIKOKANKI KEITASETO KENZOSHIMIZU HIROKIKOUNO YOHEIKUNITA SHINYAADUMI ZYUNYASAKABE TOMOHIKOABE KENICHIROMORIMOTO MINORUOKA HIROYUKI
A61K 31/166A61P 43/00A61P 35/00A61K 31/16A61K 31/09A61K 31/519A61P 19/04A61P 1/16
53
PatentIndex Score
0
Cited by
39
References
11
Claims

Abstract

A novel therapeutic drug for malignant tumors, cancer stem cells, or fibrosis is obtained. A therapeutic drug for malignant tumors or cancer stem cells is used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof. Alternatively, a therapeutic drug for fibrosis can be used that includes at least one compound selected from the group consisting of compounds represented by formulas (1), (2), and (5), a salt thereof, or a solvate thereof.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A method of treating liver fibrosis, comprising the step of administering to a subject at least one compound selected from the group consisting of compounds represented by formula (7), a salt thereof, or a solvate thereof: 
       
         
           
           
               
               
           
         
         wherein 
         R 4  represents H, F, Cl, nitro, OH, CH 2 OH, methoxy, methoxymethoxy, tert-butyl dimethyl siloxymethyl, or 4-methoxybenzyloxy. 
       
     
     
       2. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents H. 
     
     
       3. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents F. 
     
     
       4. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents Cl. 
     
     
       5. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents nitro. 
     
     
       6. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents OH. 
     
     
       7. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents CH 2 OH. 
     
     
       8. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents methoxy. 
     
     
       9. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents methoxymethoxy. 
     
     
       10. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents tert-butyl dimethyl siloxymethyl. 
     
     
       11. The method of treating liver fibrosis according to  claim 1 , wherein R 4  represents 4-methoxybenzyloxy.

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