Methods for increasing growth of beneficial bacteria in the gastrointestinal tract

Abstract

Disclosed are nutritional compositions including 2′-fucosyllactose (2′-FL) in combination with lutein and RRR-alpha-tocopherol. The nutritional compositions are useful for improving at least one of gut function, health, and development in an individual. In certain embodiments, the nutritional compositions can improve growth or maturation of the gut, as well as promote a healthy balance of beneficial bacteria in the gastrointestinal tract thereby treating and/or preventing formula intolerance or other gastrointestinal diseases and/or disorders resulting from suboptimal gastrointestinal flora population/balance.

The invention claimed is: 
     
       1. A method of improving the gut health of an infant, the method comprising administering an amount of a nutritional composition comprising therapeutically effective amounts of the human milk oligosaccharide  2 ′-fucosyllactose, lutein, and RRR-alpha-tocopherol to the infant. 
     
     
       2. The method of  claim 1 , wherein administration increases beneficial bacteria in the gut of the infant. 
     
     
       3. The method of  claim 1 , wherein the nutritional composition comprises 2′-fucosyllactose in an amount of about 0.02 mg/mL to about 20 mg/mL. 
     
     
       4. The method of  claim 1 , wherein the nutritional composition comprises lutein in an amount of about 0.001 mg/mL to about 5 mg/mL. 
     
     
       5. The method of  claim 1 , wherein the nutritional composition comprises RRR-alpha-tocopherol in an amount of about 3 mg/L to about 100 mg/L. 
     
     
       6. The method of  claim 1 , wherein the nutritional composition is an infant formula. 
     
     
       7. The method of  claim 1 , wherein the nutritional composition further comprises a probiotic. 
     
     
       8. The method of  claim 1 , wherein the probiotic is a  Bifidobacterium.    
     
     
       9. The method of  claim 1 , wherein the nutritional composition further comprises a second human milk oligosaccharide. 
     
     
       10. A method of increasing the beneficial bacteria in the gastrointestinal tract of an infant in need thereof, the method comprising administering an amount of a nutritional composition comprising therapeutically effective amounts of the human milk oligosaccharide  2 ′-fucosyllactose, lutein, and RRR-alpha-tocopherol to the infant. 
     
     
       11. The method of  claim 10 , wherein the beneficial bacteria is at least one of a  Bifidobacterium  and a  Lactobacillus.    
     
     
       12. The method of  claim 10 , wherein the nutritional composition comprises 2′-fucosyllactose in an amount of about 0.02 mg/mL to about 20 mg/mL. 
     
     
       13. The method of  claim 10 , wherein the nutritional composition comprises lutein in an amount of about 0.001 mg/mL to about 5 mg/mL. 
     
     
       14. The method of any  claim 10 , wherein the nutritional composition comprises RRR-alpha-tocopherol in an amount of about 3 mg/L to about 100 mg/L. 
     
     
       15. The method  claim 10 , wherein the nutritional composition is an infant formula. 
     
     
       16. The method  claim 10 , wherein the nutritional composition further comprises a probiotic. 
     
     
       17. The method of  claim 10 , wherein the nutritional composition further comprises a second human milk oligosaccharide.