Use of amino acid supplementation for improved muscle protein synthesis

Abstract

The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.

What is claimed is: 
     
       1. A method for stimulating muscle protein synthesis, the method comprising administering to a subject a composition comprising about 1 to 4 grams of the following concentrations of amino acids in terms of w/w %: about 1 to 2% of histidine, about 9 to 11% of isoleucine, about 35 to 38% of leucine, about 14 to 17% of lysine, about 2 to 4% of methionine, about 5 to 7% of phenylalanine, about 8 to 9% of threonine, about 9 to 11% of valine, about 0.005 to 0.8% of tryptophan, and about 8 to 11% of arginine, wherein stimulating muscle protein synthesis is increased approximately 50% compared to a subject not administered said amino acid composition. 
     
     
       2. The method of  claim 1 , wherein muscle protein synthesis is improved without physical exercise. 
     
     
       3. The method of  claim 1 , wherein the subject is a mammal. 
     
     
       4. The method of  claim 1 , wherein the subject is a human. 
     
     
       5. The method of  claim 1 , wherein the subject is a human 40 years of age or older. 
     
     
       6. The method of  claim 1 , wherein muscle protein synthesis improves approximately 50% with a minimum dose of 3.6 grams. 
     
     
       7. The method of  claim 1 , wherein the composition comprises the following concentrations of amino acids in terms of w/w %: 1.5% of histidine, 9.7% of isoleucine, 36.4% of leucine, 15.2% of lysine, 3% of methionine, 6.1% of phenylalanine, 8.5% of threonine, 10% of valine, 0.6% of tryptophan, and 9% of arginine. 
     
     
       8. The method of  claim 6 , wherein a 3.6 g dose of the composition is given to a human subject three times a day. 
     
     
       9. The method of  claim 6 , wherein a 3.6 g dose of the composition is given to a human subject one time a day. 
     
     
       10. The method of  claim 6 , wherein a 3.6 g dose of the composition is given to a human subject two times a day. 
     
     
       11. A composition comprising about 1 to 4 grams of the following amino acids; histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, valine, tryptophan, and arginine that stimulates muscle protein synthesis more than 50% with or without exercise. 
     
     
       12. A method for stimulating muscle protein synthesis using a dosage of about 1 to 4 grams, the method comprising administering to a subject a composition comprising the following concentrations of amino acids in terms of w/w %: about 1 to 2% of histidine, about 9 to 11% of isoleucine, about 35 to 38% of leucine, about 14 to 17% of lysine, about 2 to 4% of methionine, about 5 to 7% of phenylalanine, about 8 to 9% of threonine, about 9 to 11% of valine, about 0.005 to 0.8% of tryptophan, and about 8 to 11% of arginine, wherein stimulating muscle protein synthesis is increased relative to a subject not administered said amino acid composition. 
     
     
       13. The method of  claim 12 , wherein stimulating muscle protein synthesis is increased relative to a subject not administered said amino acid composition without exercise.