Compositions and methods for the delivery of therapeutics

Abstract

The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.

What is claimed is: 
     
       1. A nanoparticle comprising an amphiphilic block copolymer comprising a block of poly(oxyethylene) and a block of poly(oxypropylene) coating a crystal of a compound having the formula: 
       
         
           
           
               
               
           
         
         wherein R is —(CH 2 ) 12 CH 3 . 
       
     
     
       2. The nanoparticle of  claim 1 , wherein the diameter of the nanoparticle is about 100 nm to 1 μm. 
     
     
       3. The nanoparticle of  claim 1 , wherein said amphiphilic block copolymer is poloxamer 407. 
     
     
       4. The nanoparticle of  claim 1 , wherein said nanoparticle further comprises an amphiphilic block copolymer linked to a targeting ligand. 
     
     
       5. The nanoparticle of  claim 1 , wherein said amphiphilic block copolymer is linked to a targeting ligand. 
     
     
       6. The nanoparticle of  claim 4 , wherein said targeting ligand is a macrophage targeting ligand. 
     
     
       7. The nanoparticle of  claim 6 , wherein said macrophage targeting ligand is folate. 
     
     
       8. The nanoparticle of  claim 1 , wherein said nanoparticle comprises poloxamer 407 linked to folate. 
     
     
       9. A pharmaceutical composition comprising a nanoparticle of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       10. The pharmaceutical composition of  claim 9 , wherein said pharmaceutical composition further comprises an additional anti-HIV compound. 
     
     
       11. A method for treating and/or reducing the incidence an HIV infection in a subject in need thereof, comprising administering to said subject a nanoparticle of  claim 1 . 
     
     
       12. The method of  claim 11 , further comprising administration of an additional anti-HIV compound. 
     
     
       13. The nanoparticle of  claim 5 , wherein said targeting ligand is a macrophage targeting ligand. 
     
     
       14. The nanoparticle of  claim 13 , wherein said macrophage targeting ligand is folate.