US11318171B2ActiveUtilityA1
Methods and compositions for improving skeletal muscle protein fractional synthetic rate
Est. expiryNov 6, 2038(~12.3 yrs left)· nominal 20-yr term from priority
A61K 35/57A61P 21/00A61K 45/06
62
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Claims
Abstract
Methods and egg yolk powder containing compositions for improving skeletal muscle protein fractional synthetic rate (FSR) in mammals and inhibiting or reversing sarcopenia are provided.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1. A method for inhibiting or reversing sarcopenia in a mammal, said method comprising orally administering to the mammal on a daily basis a composition comprising egg yolk powder in an amount ranging from about 50 to about 300 mg/kg/day of said composition.
2. The method of claim 1 wherein the mammal is an older adult.
3. The method of claim 1 wherein the composition comprises a fertilized egg yolk derived product.
4. The method of claim 3 wherein the fertilized egg yolk derived product is produced via high pressure pasteurization and freeze drying of at least a portion of an egg.
5. The method of claim 1 wherein the egg yolk powder is administered in an amount effective to upregulate mTor pathway activity, downregulate ubiquitin proteasome pathway activity, downregulate serum myostatin levels and/or reduce ActRIIB expression.
6. The method of claim 1 wherein the composition comprises avian follistatin.Cited by (0)
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