Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9

Abstract

The present invention encompasses compounds of general formula (I) wherein the groups R1 to R9, X1 and X2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, e.g. cancer, pharmaceutical preparations containing such compounds and their uses as a medicament.

The invention claimed is: 
     
       1. Compound 
       
         
           
           
               
               
           
         
       
       or its salts. 
     
     
       2. A pharmaceutical preparation containing as active substance the compound of  claim 1  or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers. 
     
     
       3. Compound 
       
         
           
           
               
               
           
         
       
       or its salts. 
     
     
       4. Compound 
       
         
           
           
               
               
           
         
       
       or its salts. 
     
     
       5. A pharmaceutical preparation containing as active substance the compound of  claim 3  or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers. 
     
     
       6. A pharmaceutical preparation containing as active substance the compound of  claim 4  or a pharmaceutically acceptable salt thereof—optionally in combination with conventional excipients and/or carriers.