Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer

Abstract

The present invention relates to the field of cancer and inflammation, and in particular methods of monitoring, diagnosis, prognosis, detecting, treating and preventing cancer and inflammation conditions. The use of composition comprises method of monitoring, diagnosis, prognosis, and detecting cancer and inflammation with EN2 and/or SATB2 expression and/or activity. The pharmaceutical composition will further comprise agents that inhibit EN2 and/or SATB2 expression or activity.

What is claimed is: 
     
       1. A method for treating or preventing cancer in a subject, comprising administering to the subject a pharmaceutical composition comprising an effective amount of at least one agent that inhibits at least one of EN2 expression, EN2 transcriptional activity, SATB2 expression, or SATB2 transcriptional activity, wherein
 SATB2 and EN2 are highly expressed in the cancer, and 
 the at least one agent is a small organic molecule represented by a compound having the chemical structure of 
 
       
         
           
           
               
               
           
         
       
     
     
       2. The method of  claim 1 , wherein the at least one agent comprises a targeting moiety capable of binding to a surface of a cancer cell, wherein the targeting moiety is selected from the group consisting of aptamers, peptides, biodegradable materials, antibody-derived epitope binding domains, cellular ligands, and combination thereof. 
     
     
       3. The method of  claim 1 , wherein the method further comprises:
 determining EN2 and/or SATB2 expression level of said subject. 
 
     
     
       4. The method of  claim 1 , wherein the at least one agent is administered in nanoparticles. 
     
     
       5. The method of  claim 1 , wherein the at least one agent is administered to the subject in combination with one or more chemotherapeutic drugs or radiation for treatment and prevention of cancer.