US11690577B2ActiveUtilityA1

Systems and methods for dynamically and intelligently monitoring a host's glycemic condition after an alert is triggered

Assignee: DEXCOM INCPriority: Oct 30, 2012Filed: May 27, 2020Granted: Jul 4, 2023

Est. expiryOct 30, 2032(~6.3 yrs left)· nominal 20-yr term from priority

Inventors:Hari Hampapuram Anna Leigh Davis Naresh C. Bhavaraju Apurv Ullas Kamath Claudio Cobelli Giovanni Sparacino Andrea Facchinetti Chiara Zecchin

A61B 5/002A61B 5/0004A61B 5/4848A61B 5/0022A61B 5/746A61B 5/14503A61B 5/7275A61B 5/0031A61B 5/4866A61B 5/7221A61B 5/14532G16H 50/30G16H 40/67

PatentIndex Score

Cited by

318

References

226

Claims

Abstract

Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.

Claims

exact text as granted — not AI-modified

What is claimed is:

1. A non-transitory computer readable medium for storing instructions that when executed perform a method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

2. The non-transitory computer readable medium of claim 1 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

3. The non-transitory computer readable medium of claim 1 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

4. The non-transitory computer readable medium of claim 1 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

5. The non-transitory computer readable medium of claim 1 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

6. The non-transitory computer readable medium of claim 1 , wherein the method further comprises:
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
providing a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

7. The non-transitory computer readable medium of claim 1 , wherein the method further comprises:
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

8. The non-transitory computer readable medium of claim 1 , the method further comprising:
evaluating sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a third glycemic indicator if the third criteria is met.

9. The non-transitory computer readable medium of claim 1 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

10. The non-transitory computer readable medium of claim 1 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

11. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

12. A system for activating indicators, the system comprising:
one or more processors; and
at least one memory storing instructions that when executed by at least one of the one or more processors causes the at least one of the one or more processors to:
evaluate sensor data derived from a transcutaneous glucose sensor to determine whether a real time glucose value meets one or more user settable first criteria;
evaluate sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
provide an output including a first glycemic indicator if the one or more user settable first criteria is met, and provide an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

13. The system of claim 12 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

14. The system of claim 12 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

15. The system of claim 12 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

16. The system of claim 12 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

17. The system of claim 12 , the at least one of the one or more processors is further configured to:
evaluate the sensor data to determine whether the real time glucose value meets one or more user settable third criteria; and
provide a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

18. The system of claim 12 , the at least one of the one or more processors is further configured to:
evaluate the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
provide a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

19. The system of claim 12 , the at least one of the one or more processors is further configured to:
evaluate the sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
provide an output including a third glycemic indicator if the third criteria is met.

20. The system of claim 12 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

21. The system of claim 12 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

22. The system of claim 21 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

23. The system of claim 12 , further comprising sensor electronics configured to process one or more sensor signals and provide processed sensor signals to the one or more processors for deriving the sensor data.

24. The system of claim 12 , further comprising sensor electronics configured to process one or more sensor signals to derive the sensor data.

25. The system of claim 12 , the system further comprising:
a processor module configured to process one or more sensor signals from the transcutaneous glucose sensor to derive the sensor data.

26. The system of claim 25 , wherein the processor module comprises sensor electronics and the one or more processors.

27. The system of claim 12 , further comprising sensor electronics comprising the one or more processors and the least one memory.

28. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria are invisible to the user and preset or fixed.

29. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

30. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

31. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

32. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

33. The non-transitory computer readable medium of claim 1 , further comprising iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

34. The non-transitory computer readable medium of claim 1 , further comprising applying a conversion function to produce an output representative of a concentration of analyte.

35. The non-transitory computer readable medium of claim 34 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

36. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

37. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

38. The non-transitory computer readable medium of claim 1 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

39. The non-transitory computer readable medium of claim 38 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

40. The non-transitory computer readable medium of claim 39 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display the predicted glucose value at a future point in time.

41. The non-transitory computer readable medium of claim 1 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

42. The system of claim 12 , wherein the predicted glucose value is based on a first real time glucose value and a second real time glucose value.

43. The system of claim 12 , wherein the second high threshold is invisible to the user and preset or fixed.

44. The system of claim 12 , wherein the second high threshold is determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

45. The system of claim 12 , wherein the second high threshold represents a dangerously low glucose value.

46. The system of claim 12 , wherein the second high threshold is set at lower threshold than the first high threshold.

47. The system of claim 12 , wherein the first and second high thresholds are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

48. The system of claim 12 , wherein the system is further configured to iteratively repeat:
evaluating sensor data derived from the transcutaneous glucose sensor indicative of a glucose value to determine whether a real time glucose value meets a first threshold that is settable,
evaluating sensor data derived from the transcutaneous glucose sensor indicative of a glucose value to determine whether a second real time glucose value meets a second threshold that is non user settable, and
evaluating sensor data derived from the transcutaneous glucose sensor indicative of a glucose value to determine whether a predicted glucose value meets the second threshold that is non user settable, on receipt of any new sensor data.

49. The system of claim 21 , wherein the system is further configured to apply a conversion function to produce an output representative of a concentration of analyte.

50. The system of claim 49 , wherein the conversion function takes into account one or more of sensitivity (slope), baseline (intercept), drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

51. The system of Claim 12 , wherein the first and second high thresholds are evaluated for the each sensor data point received from the transcutaneous glucose sensor.

52. The system of claim 12 , wherein the predicted glucose value uses past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or horizon.

53. The system of claim 52 , wherein the system is further configured to use a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

54. The system of claim 53 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display the predicted glucose value at a future point in time.

55. A method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

56. The method of claim 55 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

57. The method of claim 55 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

58. The method of claim 55 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

59. The method of claim 55 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

60. The method of claim 55 , further comprising::
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria; and
providing a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

61. The method of claim 55 , further comprising::
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

62. The method of claim 55 , the method further comprising:
evaluating sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a third glycemic indicator if the third criteria is met.

63. The method of claim 55 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

64. The method of claim 55 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

65. The method of claim 55 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

66. A non-transitory computer readable medium for storing instructions that when executed perform a method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria;
evaluating sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, and providing an output including a third glycemic indicator if the third criteria is met.

67. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

68. The non-transitory computer readable medium of claim 67 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

69. The non-transitory computer readable medium of Claim 68 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

70. The non-transitory computer readable medium of claim 66 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

71. The non-transitory computer readable medium of claim 66 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time real time glucose value meets a glucose threshold.

72. The non-transitory computer readable medium of claim 66 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

73. The non-transitory computer readable medium of claim 66 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

74. The non-transitory computer readable medium of claim 66 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

75. The non-transitory computer readable medium of claim 66 , wherein the method further comprises:
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
providing a second output, the second output including the third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

76. The non-transitory computer readable medium of claim 66 , wherein the method further comprises:
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including the third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

77. The non-transitory computer readable medium of claim 66 , the method further comprising:
evaluating the sensor data to determine whether the second real time glucose value meets one or more non user settable third criteria; and
providing an output including the third glycemic indicator if the third criteria is met.

78. The non-transitory computer readable medium of claim 66 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

79. The non-transitory computer readable medium of claim 66 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

80. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

81. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria are invisible to a user and preset or fixed.

82. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

83. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

84. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

85. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

86. The non-transitory computer readable medium of claim 66 , wherein the method further comprises iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

87. The non-transitory computer readable medium of claim 66 , wherein the method further comprises applying a conversion function to produce an output representative of a concentration of analyte.

88. The non-transitory computer readable medium of claim 87 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

89. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

90. The non-transitory computer readable medium of claim 66 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

91. A system for activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the system comprising:
one or more processors; and
at least one memory storing instructions that when executed by at least one of the one or more processors causes the at least one of the one or more processors to:
evaluate sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluate sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria;
evaluate sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
provide an output including a first glycemic indicator if the one or more user settable first criteria is met, providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, and providing an output including a third glycemic indicator if the third criteria is met.

92. The system of claim 91 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

93. The system of claim 92 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

94. The system of Claim 93 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

95. The system of claim 91 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

96. The system of claim 91 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

97. The system of claim 91 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

98. The system of claim 91 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

99. The system of claim 91 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluate the sensor data to determine whether the real time glucose value meets one or more user settable third criteria; and
provide a second output, the second output including the third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

100. The system of claim 91 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluate the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
provide a second output including the third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

101. The system of claim 91 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluating the sensor data to determine whether the second real time glucose value meets one or more non user settable third criteria; and
providing an output including the third glycemic indicator if the third criteria is met.

102. The system of claim 91 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

103. The system of claim 91 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

104. The system of claim 91 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

105. The system of claim 91 , wherein the one or more non user settable second criteria are invisible to a user and preset or fixed.

106. The system of claim 91 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

107. The system of claim 91 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

108. The system of claim 91 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

109. The system of claim 91 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

110. The system of claim 91 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
iteratively repeat the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

111. The system of claim 91 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
apply a conversion function to produce an output representative of a concentration of analyte.

112. The system of claim 111 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

113. The system of claim 91 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

114. The system of claim 91 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

115. A method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria;
evaluating sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, and providing an output including a third glycemic indicator if the third criteria is met.

116. The method of claim 115 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

117. The method of claim 116 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

118. The method of Claim 117 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

119. The method of claim 115 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

120. The method of claim 115 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

121. The method of claim 115 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

122. The method of claim 115 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

123. The method of claim 115 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

124. The method of claim 115 , further comprising::
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
providing a second output, the second output including the third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

125. The method of claim 115 , further comprising::
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including the third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

126. The method of claim 115 , the method further comprising:
evaluating the sensor data to determine whether the second real time glucose value meets one or more non user settable third criteria; and
providing an output including the third glycemic indicator if the third criteria is met.

127. The method of claim 115 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

128. The method of claim 115 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

129. The method of claim 115 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

130. The method of claim 115 , wherein the one or more non user settable second criteria are invisible to a user and preset or fixed.

131. The method of claim 115 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

132. The method of claim 115 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

133. The method of claim 115 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

134. The method of claim 115 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

135. The method of claim 115 , further comprising:
iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

136. The method of claim 115 , further comprising:
applying a conversion function to produce an output representative of a concentration of analyte.

137. The method of claim 136 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory- derived information or other calibrations or adjustment to the sensor data.

138. The method of claim 115 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

139. The method of claim 115 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

140. A non-transitory computer readable medium for storing instructions that when executed perform a method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein:
the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable, and
the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

141. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

142. The non-transitory computer readable medium of claim 141 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

143. The non-transitory computer readable medium of Claim 142 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

144. The non-transitory computer readable medium of claim 140 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

145. The non-transitory computer readable medium of claim 140 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

146. The non-transitory computer readable medium of claim 140 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

147. The non-transitory computer readable medium of claim 140 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

148. The non-transitory computer readable medium of claim 140 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

149. The non-transitory computer readable medium of claim 140 , wherein the method further comprises:
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
providing a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

150. The non-transitory computer readable medium of claim 140 , wherein the method further comprises:
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

151. The non-transitory computer readable medium of claim 140 , the method further comprising:
evaluating the sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a third glycemic indicator if the third criteria is met.

152. The non-transitory computer readable medium of claim 140 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

153. The non-transitory computer readable medium of claim 140 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

154. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

155. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria are invisible to the user and preset or fixed.

156. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

157. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

158. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

159. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

160. The non-transitory computer readable medium of claim 140 , further comprising iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

161. The non-transitory computer readable medium of claim 140 , further comprising applying a conversion function to produce an output representative of a concentration of analyte.

162. The non-transitory computer readable medium of claim 161 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

163. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

164. The non-transitory computer readable medium of claim 140 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

165. A system for activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the system comprising:
one or more processors; and
at least one memory storing instructions that when executed by at least one of the one or more processors causes the at least one of the one or more processors to:
evaluate sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluate sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
provide an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein:
the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable, and
the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

166. The system of claim 165 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

167. The system of claim 166 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

168. The system of Claim 167 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

169. The system of claim 165 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

170. The system of claim 165 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

171. The system of claim 165 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

172. The system of claim 165 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

173. The system of claim 165 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

174. The system of claim 165 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluate the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
provide a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

175. The system of claim 165 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluate the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
provide a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

176. The system of claim 165 , wherein the at least one memory further stores instructions that when executed by the at least one of the one or more processors further causes the at least one of the one or more processors to:
evaluate the sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
provide an output including a third glycemic indicator if the third criteria is met.

177. The system of claim 165 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

178. The system of claim 165 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

179. The system of claim 165 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

180. The system of claim 165 , wherein the one or more non user settable second criteria are invisible to the user and preset or fixed.

181. The system of claim 165 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

182. The system of claim 165 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

183. The system of claim 165 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

184. The system of claim 165 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

185. The system of claim 165 , further comprising iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

186. The system of claim 165 , further comprising applying a conversion function to produce an output representative of a concentration of analyte.

187. The system of Claim 186 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

188. The system of claim 187 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

189. The system of claim 165 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

190. A method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein:
the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable, and
the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in a predetermined time frame or time horizon.

191. The method of claim 190 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

192. The method of claim 191 , further comprising using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting the predetermined time frame or time horizon.

193. The method of Claim 192 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

194. The method of claim 190 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

195. The method of claim 190 , wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether the real time glucose value meets a glucose threshold.

196. The method of claim 190 , wherein the one or more user settable first criteria comprises a rate of change criterion, and wherein the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

197. The method of claim 190 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether the predictive glucose value meets a glucose threshold.

198. The method of claim 190 , wherein the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria comprises determining whether an amplitude of rate of change or direction of rate of change meets a rate of change criterion.

199. The method of claim 190 , further comprising:
evaluating the sensor data to determine whether the real time glucose value meets one or more user settable third criteria;
providing a second output, the second output including a third glycemic indicator if the one or more user settable third criteria is met, wherein the third glycemic indicator comprises a hypoglycemic indicator and wherein the one or more user settable third criteria comprises a low threshold that is configured to be user settable.

200. The method of claim 190 , further comprising:
evaluating the sensor data to determine whether the predicted glucose value meets one or more non user settable third criteria; and
providing a second output including a third glycemic indicator if the one or more non user settable third criteria are met, wherein the third glycemic indicator comprises a hypoglycemic indicator, and wherein the one or more non user settable third criteria comprises a low threshold that is not user settable.

201. The method of claim 190 , the method further comprising:
evaluating the sensor data to determine whether a second real time glucose value meets one or more non user settable third criteria; and
providing an output including a third glycemic indicator if the third criteria is met.

202. The method of claim 190 , wherein the first glycemic indicator and the second glycemic indicator comprise an indicator that has a particular set of instructions associated with it depending on whether the first glycemic indicator was activated based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

203. The method of claim 190 , wherein the output comprises at least one of an audible, tactile or visual output, and wherein the output is differentiated and/or provides information selectively based on whether the first glycemic indicator was outputted based on the sensor data meeting the one or more user settable first criteria or whether the second glycemic indicator was outputted based on the sensor data meeting the one or more non user settable second criteria.

204. The method of claim 190 , wherein the one or more non user settable second criteria are programmed at a factory in such a way that a user is not able to modify the one or more non user settable second criteria during use.

205. The method of claim 190 , wherein the one or more non user settable second criteria are invisible to the user and preset or fixed.

206. The method of claim 190 , wherein the one or more non user settable second criteria are determined from a sensor manufacturer, using one or more of user historical data, population historical data, and/or sensor historical data.

207. The method of claim 190 , wherein the one or more non user settable second criteria represent a dangerously low glucose value.

208. The method of claim 190 , wherein the one or more non user settable second criteria is set at lower threshold than the one or more user settable first criteria.

209. The method of claim 190 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are differentiated from a target zone viewable to a user on a monitor or a device of the user with a viewing screen.

210. The method of claim 190 , further comprising iteratively repeating the evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria and the evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, on receipt of any new sensor data.

211. The method of claim 190 , further comprising applying a conversion function to produce an output representative of a concentration of analyte.

212. The method of claim 211 , wherein the conversion function takes into account one or more of sensitivity, baseline, drift, temperature correction, factory-derived information or other calibrations or adjustment to the sensor data.

213. The method of claim 190 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for the same sensor data.

214. The method of claim 190 , wherein the one or more non user settable second criteria and the one or more user settable first criteria are evaluated for each sensor data point received as part of the sensor data from the transcutaneous analyte sensor.

215. A non-transitory computer readable medium for storing instructions that when executed perform a method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, wherein the evaluating sensor data to determine whether the predicted glucose value meets the one or more non user settable second criteria further comprises using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting a predetermined time frame or time horizon used as part of the one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

216. The non-transitory computer readable medium of claim 215 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

217. The non-transitory computer readable medium of claim 215 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

218. The non-transitory computer readable medium of claim 215 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

219. A system for activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the system comprising:
one or more processors; and
at least one memory storing instructions that when executed by at least one of the one or more processors causes the at least one of the one or more processors to:
evaluate sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluate sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, wherein the evaluating sensor data to determine whether the predicted glucose value meets the one or more non user settable second criteria further comprises using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting a predetermined time frame or time horizon used as part of the one or more non user settable second criteria; and
provide an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

220. The system of claim 219 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

221. The system of claim 219 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

222. The system of claim 219 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

223. A method of activating indicators based on sensor data derived from one or more signals received from a transcutaneous analyte sensor, the method comprising:
evaluating sensor data to determine whether a real time glucose value meets one or more user settable first criteria;
evaluating sensor data to determine whether a predicted glucose value meets one or more non user settable second criteria, wherein the evaluating sensor data to determine whether the predicted glucose value meets the one or more non user settable second criteria further comprises using a time lag adjustment algorithm or set of instructions in determining or in conjunction with setting a predetermined time frame or time horizon used as part of the one or more non user settable second criteria; and
providing an output including a first glycemic indicator if the one or more user settable first criteria is met, and providing an output including a second glycemic indicator if the one or more non user settable second criteria are met, wherein the first glycemic indicator and second glycemic indicator comprise a hyperglycemic indicator and wherein the one or more user settable first criteria comprise a first high threshold that is configured to be user settable and the one or more non user settable second criteria comprise a second high threshold that is not user settable.

224. The method of claim 223 , wherein the one or more non user settable second criteria is completely predictive in using past and/or current sensor data to determine if a user will meet or cross through a predetermined threshold in the predetermined time frame or time horizon.

225. The method of claim 223 , wherein the time lag adjustment algorithm or set of instructions uses near time prediction to predict and/or display an estimated glucose value at a future point in time.

226. The method of claim 223 , wherein the predicted glucose value is a future glucose value predicted based on the real time glucose value.

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Systems and methods for dynamically and intelligently monitoring a host&#39;s glycemic condition after an alert is triggered

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Systems and methods for dynamically and intelligently monitoring a host's glycemic condition after an alert is triggered