Systems and methods for optimization of plasma collection volumes

Abstract

A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

What is claimed is: 
     
       1. A method of collecting plasma, comprising:
 receiving input from an operator via a touchscreen of a plasma collection device; 
 receiving donor parameters at a controller of the plasma collection device, wherein the donor parameters are received electronically from a donor management system; 
 storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume; 
 setting the target volume for raw plasma prior to blood collection from a donor; 
 controlling the plasma collection device to operate draw and return phases to withdraw whole blood from the donor and separate the whole blood into a plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor, 
 wherein each draw and return phase comprises: 
 introducing whole blood from the donor to a separator via a donor line; 
 combining anticoagulant with the whole blood from the donor using an anticoagulant line based on an anticoagulant ratio (ACR); 
 separating whole blood into the plasma product and the second blood component comprising red blood cells; and 
 sending the plasma product to a plasma product collection container, 
 wherein the controller is further configured to operate the draw and return phases until a volume of raw plasma (VRP) in the plasma product collection container equals the target volume of raw plasma, the volume of raw plasma (VRP) based on a measured volume of plasma product (VPP). 
 
     
     
       2. The method of  claim 1 , wherein ACR=Volume of Whole Blood/Volume of Anticoagulant. 
     
     
       3. The method of  claim 1 , further comprising calculating the volume of raw plasma (VRP) in the collection container based on a measured volume of plasma product (VPP), the ACR and a hematocrit of the donor. 
     
     
       4. The method of  claim 1 , further comprising receiving the donor's weight and hematocrit electronically at the controller from the donor management system, wherein the donor management system is used for qualification screening. 
     
     
       5. The method of  claim 1 , further comprising calculating the target volume for raw plasma by calculating a fraction of total donor plasma volume. 
     
     
       6. The method of  claim 1 , further comprising performing the draw and return cycles at least three times and determining a volume of whole blood to be drawn in a final draw phase which is different than a volume drawn in a prior draw phase. 
     
     
       7. The method of  claim 1 , further comprising combining anticoagulant with the whole blood from the donor at an anticoagulant ratio (ACR) of about 16 parts of whole blood to 1 part of anticoagulant. 
     
     
       8. The method of  claim 1 , wherein the donor management system calculates the target volume for raw plasma based at least in part on donor height and weight used to calculate total donor blood volume and hematocrit used to calculate total donor plasma volume, further comprising transmitting the target volume for raw plasma from the donor management system to the controller. 
     
     
       9. The method of  claim 1 , wherein ACR is a ratio of volume of anticoagulant to volume of anticoagulated blood. 
     
     
       10. The method of  claim 1 , further comprising receiving via the touchscreen a donor ID, donor weight, donor hematocrit and a target plasma volume. 
     
     
       11. The method of  claim 1 , further comprising calculating a raw plasma target volume by establishing three ranges of donor weight and selecting the raw plasma target volume for the range of weight that is inclusive of the weight of the donor. 
     
     
       12. A method of collecting plasma, comprising:
 receiving input from an operator via a touchscreen of a plasma collection device; 
 receiving donor parameters at a controller of the plasma collection device, wherein the donor parameters are received electronically from a donor management system; 
 determining a target volume for plasma product and/or raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume and hematocrit (Hct) used to calculate total donor plasma volume; 
 controlling the plasma collection device to operate collection and reinfusion cycles to withdraw whole blood from a donor and separate the whole blood into a plasma product and a second blood component comprising red blood cells and to reinfuse the second blood component to the donor, wherein each collection and reinfusion cycle comprises: 
 introducing the whole blood from the donor to a blood separator; 
 combining anticoagulant with the whole blood from the donor based on an anticoagulant ratio (ACR); 
 separating whole blood into the plasma product and the second blood component comprising red blood cells; and 
 sending the plasma product to a plasma product collection container, 
 wherein the controller controls the plasma collection device to operate the collection and reinfusion cycles on the donor at least three times, wherein a final collection and reinfusion cycle comprises drawing a volume of whole blood which is less than a volume of whole blood drawn in a prior collection and reinfusion cycle. 
 
     
     
       13. The method of  claim 12 , wherein the controller uses the parameters received from the donor management system to determine the target volume for plasma product and/or raw plasma. 
     
     
       14. The method of  claim 13 , further comprising performing qualification screening using the donor management system. 
     
     
       15. The method of  claim 12 , wherein the donor management system calculates the target volume for plasma product and/or raw plasma and the controller determines the target volume for plasma product and/or raw plasma by receiving the target volume for plasma product and/or raw plasma from the donor management system. 
     
     
       16. The method of  claim 12 , further comprising determining the total donor blood volume before whole blood is withdrawn from the donor during a donation. 
     
     
       17. A method of collecting plasma, comprising:
 receiving input from an operator via a touchscreen of a plasma collection device; 
 receive donor parameters at a controller local to the plasma collection device, wherein the donor parameters are received electronically from a donor management system; 
 setting a target volume for raw plasma which is based at least in part on donor parameters comprising height and weight used to calculate total donor blood volume and hematocrit (Hct) used to calculate total donor plasma volume, wherein the target volume for raw plasma is set prior to blood collection from the donor; 
 controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into a plasma product and a second blood component and to return the second blood component to the donor, wherein each draw and return phase comprises: 
 pumping whole blood from a donor to a separator of the plasma collection device; 
 combining anticoagulant from an anticoagulant source with the whole blood from the donor based on an anticoagulant ratio (ACR); 
 separating the whole blood into a plasma product and a second blood component comprising red blood cells; and 
 sending the plasma product to a plasma product collection container, 
 wherein the controller is further configured to operate the draw and return phases until a volume of raw plasma (VRP) in the plasma product collection container equals the target volume of raw plasma, the volume of raw plasma (VRP) based on a measured volume of plasma product (VPP). 
 
     
     
       18. The method of  claim 17 , wherein ACR=Volume of Whole Blood/Volume of Anticoagulant. 
     
     
       19. The method of  claim 17 , further comprising performing donor qualification screening using the donor management system, wherein the donor parameters received from the donor management system comprise the donor weight and height and hematocrit (Hct). 
     
     
       20. The method of  claim 17 , wherein the controller is programmed to calculate the target volume of raw plasma (VRP) by calculating a fraction of the total donor blood volume or the total donor plasma volume. 
     
     
       21. The method of  claim 17 , further comprising operating the draw and return phases at least three times and further comprising determining a volume of whole blood to be drawn in a final draw phase which is different than a volume drawn in a prior draw phase. 
     
     
       22. The method of  claim 17 , further comprising combining the anticoagulant with the whole blood at an anticoagulant ratio (ACR) of about 16 parts of whole blood to 1 part of anticoagulant. 
     
     
       23. The method of  claim 17 , further comprising: calculating the target volume for raw plasma at the donor management system based at least in part on the donor height and weight used to calculate the total donor blood volume and the hematocrit used to calculate the total donor plasma volume; and transmitting the target volume for raw plasma from the donor management system to the controller.