US11744845B2ActiveUtilityPatentIndex 58

Compounds,compositions, and methods for the treatment of disease

Assignee: F STAR THERAPEUTICS INCPriority: Jul 6, 2016Filed: Jun 4, 2021Granted: Sep 5, 2023

Est. expiryJul 6, 2036(~10 yrs left)· nominal 20-yr term from priority

Inventors:IYER RADHAKRISHNAN P SHERI ANJANEYULU PADMANABHAN SEETHARAMAIYER MEHER GEETA ZHOU SHENGHUA CHALLA SREERUPA GIMI RAYOMAND H CLEARY DILLON

A61K 31/513A61K 31/519A61K 45/06C07H 19/213Y02A50/30A61K 39/12A61K 9/0029C07H 21/02A61K 31/7084A61K 9/0019C07H 21/00A61K 2039/55511A61K 39/39A61P 35/00C07H 21/04

58

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References

22

Claims

Abstract

Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.

Claims

exact text as granted — not AI-modified

What is claimed is:

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is

4. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein the compound is

6. The compound of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 1 , wherein the compound is

8. A method of treating cancer, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the cancer is acute monocytic leukemia, lymphoma, melanoma, colon cancer, or breast cancer.

9. The method of claim 8 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

10. The method of claim 8 , wherein the compound is

11. The method of claim 8 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

12. The method of claim 8 , wherein the compound is

13. The method of claim 8 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

14. The method of claim 8 , wherein the compound is

15. The method of claim 8 , wherein the cancer is colon cancer.

16. The method of claim 8 , wherein the cancer is breast cancer.

17. The method of claim 16 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

18. The method of claim 16 , wherein the compound is

19. The method of claim 16 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

20. The method of claim 16 , wherein the compound is

21. The method of claim 16 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

22. The method of claim 16 , wherein the compound is

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