Dynamic super bolus generation

Abstract

Techniques related to automatically generating a super bolus may include determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal. The amount of the augmented meal bolus may exceed a sufficient amount for counteracting a glucose level increase caused by the meal. In some embodiments, the techniques may further include determining a duration of a postprandial reduction period during which basal dosage deliveries to the patient are to be reduced. In some other embodiments, the techniques may further include delivering the augmented meal bolus to the patient prior to determining whether or not to cause reduction of basal dosage deliveries. More specifically, a glucose level of the patient may be obtained after delivery of the augmented meal bolus, and the obtained glucose level may be used to determine whether to reduce basal dosage deliveries.

What is claimed is: 
     
       1. A system for automatically generating a super bolus, the system comprising:
 one or more processors; and 
 one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause performance of:
 determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal, the amount of the augmented bolus exceeding a sufficient amount for counteracting a glucose level increase caused by the meal; 
 causing delivery of the augmented meal bolus to the patient in the determined amount; 
 after causing delivery of the augmented meal bolus, obtaining a glucose level of the patient; and 
 based on the glucose level, causing reduction of basal dosage deliveries to the patient. 
 
 
     
     
       2. The system of  claim 1 , wherein causing reduction of the basal dosage deliveries comprises:
 determining an insulin feedback term value based on the amount of the augmented meal bolus; 
 determining a difference between the obtained glucose level and a target glucose level; and 
 causing reduction of the basal dosage deliveries when the insulin feedback term value is greater than the difference between the obtained glucose level and the target glucose level. 
 
     
     
       3. The system of  claim 1 , wherein causing reduction of the basal dosage deliveries comprises:
 determining a probability of postprandial hypoglycemia based on providing the obtained glucose level as input to a mathematical model; and 
 causing reduction of the basal dosage deliveries when the probability exceeds a predetermined threshold value. 
 
     
     
       4. The system of  claim 1 , wherein determining the amount of the augmented meal bolus comprises:
 obtaining an amount of carbohydrates included in the meal; and 
 multiplying an adjusted insulin-to-carbohydrate ratio by the amount of carbohydrates included in the meal. 
 
     
     
       5. The system of  claim 1 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on:
 determining an average rate of basal dosage deliveries during a historical time period; and 
 multiplying the average rate of basal dosage deliveries by a predetermined duration. 
 
     
     
       6. The system of  claim 1 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on determining a total amount of basal dosage deliveries during a historical time period. 
     
     
       7. The system of  claim 1 , wherein the one or more processor-readable storage media further store instructions which, when executed by the one or more processors, cause performance of:
 after causing reduction of the basal dosage deliveries, obtaining a second glucose level of the patient; 
 based on the second glucose level, causing increase of basal dosage deliveries. 
 
     
     
       8. A processor-implemented method for automatically generating a super bolus, the method comprising:
 determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal, the amount of the augmented bolus exceeding a sufficient amount for counteracting a glucose level increase caused by the meal; 
 causing delivery of the augmented meal bolus to the patient in the determined amount; 
 after causing delivery of the augmented meal bolus, obtaining a glucose level of the patient; and 
 based on the glucose level, causing reduction of basal dosage deliveries to the patient. 
 
     
     
       9. The method of  claim 8 , wherein causing reduction of the basal dosage deliveries comprises:
 determining an insulin feedback term value based on the amount of the augmented meal bolus; 
 determining a difference between the obtained glucose level and a target glucose level; and 
 causing reduction of the basal dosage deliveries when the insulin feedback term value is greater than the difference between the obtained glucose level and the target glucose level. 
 
     
     
       10. The method of  claim 8 , wherein causing reduction of the basal dosage deliveries comprises:
 determining a probability of postprandial hypoglycemia based on providing the obtained glucose level as input to a mathematical model; and 
 causing reduction of the basal dosage deliveries when the probability exceeds a predetermined threshold value. 
 
     
     
       11. The method of  claim 8 , wherein determining the amount of the augmented meal bolus comprises:
 obtaining an amount of carbohydrates included in the meal; and 
 multiplying an adjusted insulin-to-carbohydrate ratio by the amount of carbohydrates included in the meal. 
 
     
     
       12. The method of  claim 8 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on:
 determining an average rate of basal dosage deliveries during a historical time period; and 
 multiplying the average rate of basal dosage deliveries by a predetermined duration. 
 
     
     
       13. The method of  claim 8 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on determining a total amount of basal dosage deliveries during a historical time period. 
     
     
       14. The method of  claim 8 , further comprising:
 after causing reduction of the basal dosage deliveries, obtaining a second glucose level of the patient; 
 based on the second glucose level, causing increase of basal dosage deliveries. 
 
     
     
       15. One or more non-transitory processor-readable storage media storing instructions which, when executed by one or more processors, cause performance of:
 determining an amount of an augmented meal bolus to be delivered to a patient for regulating the patient's glycemic response to a meal, the amount of the augmented bolus exceeding a sufficient amount for counteracting a glucose level increase caused by the meal; 
 causing delivery of the augmented meal bolus to the patient in the determined amount; 
 after causing delivery of the augmented meal bolus, obtaining a glucose level of the patient; and 
 based on the glucose level, causing reduction of basal dosage deliveries to the patient. 
 
     
     
       16. The one or more non-transitory processor-readable storage media of  claim 15 , wherein causing reduction of the basal dosage deliveries comprises:
 determining an insulin feedback term value based on the amount of the augmented meal bolus; 
 determining a difference between the obtained glucose level and a target glucose level; and 
 causing reduction of the basal dosage deliveries when the insulin feedback term value is greater than the difference between the obtained glucose level and the target glucose level. 
 
     
     
       17. The one or more non-transitory processor-readable storage media of  claim 15 , wherein causing reduction of the basal dosage deliveries comprises:
 determining a probability of postprandial hypoglycemia based on providing the obtained glucose level as input to a mathematical model; and 
 causing reduction of the basal dosage deliveries when the probability exceeds a predetermined threshold value. 
 
     
     
       18. The one or more non-transitory processor-readable storage media of  claim 15 , wherein determining the amount of the augmented meal bolus comprises:
 obtaining an amount of carbohydrates included in the meal; and 
 multiplying an adjusted insulin-to-carbohydrate ratio by the amount of carbohydrates included in the meal. 
 
     
     
       19. The one or more non-transitory processor-readable storage media of  claim 15 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on:
 determining an average rate of basal dosage deliveries during a historical time period; and 
 multiplying the average rate of basal dosage deliveries by a predetermined duration. 
 
     
     
       20. The one or more non-transitory processor-readable storage media of  claim 15 , wherein determining the amount of the augmented meal bolus comprises calculating an excess amount to be added to the sufficient amount based on determining a total amount of basal dosage deliveries during a historical time period.