US11759452B2ActiveUtilityA1
Compositions of matter and pharmaceutical compositions
Est. expiryMay 8, 2040(~13.8 yrs left)· nominal 20-yr term from priority
A61K 31/405A61K 31/4045A61K 31/48A61K 31/675C07D 209/16A61K 31/55A61K 9/0053A61K 9/0014A61K 9/0043A61K 9/2054A61K 9/06A61K 9/7061A61K 9/2018A61K 9/7069A61K 9/2027A61K 9/2013A61K 9/2009
94
PatentIndex Score
3
Cited by
28
References
19
Claims
Abstract
Pharmaceutical formulations of novel indole compounds and psilocybin analogs are manufactured, provided in novel oral, transdermal, and nasal pharmaceutical compositions for use to treat neurological, mood or abuse diseases and disorders.
Claims
exact text as granted — not AI-modifiedThe invention claimed is:
1. A compound of the formula of Structure (1):
wherein:
X is CF 3 , or a halogen selected from the group consisting of Cl, Br, I, and astatine;
R 1 consists of an aliphatic substituent with a primary, secondary, tertiary, or quaternary amine; and
R 2 is hydroxyl, an ester, an ether, an aldehyde, an acid, an amide, a thiol, a sulfone, a sulfonamide or combinations thereof.
2. The compound of claim 1 , wherein R 1 is a tertiary amine.
3. The compound of claim 1 , wherein X is Cl, Br, or I.
4. The compound of claim 2 , wherein X is Cl, Br, or I.
5. The compound of claim 1 , wherein R 2 is an ester.
6. The compound of claim 2 , wherein R 2 is an ester.
7. The compound of claim 3 , wherein R 2 is an ester.
8. The compound of claim 4 , wherein R 2 is an ester.
9. The compound of claim 5 , wherein the ester is an acetate ester.
10. The compound of claim 6 , wherein the ester is an acetate ester.
11. The compound of claim 7 , wherein the ester is an acetate ester.
12. The compound of claim 8 , wherein the ester is an acetate ester.
13. A compound of the formula of Structure (1):
wherein:
X is Br;
R 1 consists of an aliphatic substituent with a primary, secondary, tertiary, or quaternary amine; and
R 2 is hydroxyl, an ester, an ether, an aldehyde, an acid, an amide, a thiol, a sulfone, a sulfonamide or combinations thereof.
14. The compound of claim 2 , wherein X is Br.
15. The compound of claim 5 , wherein X is Br.
16. The compound of claim 6 , wherein X is Br.
17. The compound of claim 9 , wherein X is Br.
18. The compound of claim 10 , wherein X is Br.
19. The compound of claim 1 , wherein the composition has the following structure:Cited by (0)
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