Device for providing therapeutic gas

Abstract

The disclosure concerns various devices implemented to provide a therapeutic gas rich environment to promote healing, reduce fibrosis and scar formations while maintaining anti-inflammatory, anti-thrombotic, antimicrobial, and vasodilating properties. The device generally includes a gas-donor composition that is embedded within a fibrous holding layer. Coupled to one side of the fibrous holding layer is a water-permeable layer and coupled to an opposite side of the fibrous holding layer is a gas-permeable layer. The water-permeable layer is configured to receive and communicate water to the gas-donor composition, wherein upon contact with the water, the gas-donor composition is configured to deliver a therapeutic gas through the gas-permeable layer to a treatment site of a subject.

What is claimed is: 
     
       1. A device for providing therapeutic gas to a subject at a treatment site, the device comprising:
 a water-permeable layer; 
 a gas-permeable layer; and 
 a fibrous holding layer disposed between each of the water-permeable layer and the gas-permeable layer, the fibrous holding layer comprising a gas-donor composition embedded therein; 
 wherein: 
 the gas-donor composition is one that emits therapeutic gas upon contact with water, and 
 the device is adapted to direct the therapeutic gas emitted therefrom toward the treatment site; 
 wherein each of the water-permeable layer and the gas-permeable layer further comprises a bonding layer on a surface thereof; and 
 further wherein the fibrous holding layer comprises a plurality of holes, and the water-permeable layer and the gas-permeable layer are bonded together at each of the plurality of holes by the bonding layer to form a plurality of overlapping junctions. 
 
     
     
       2. The device of  claim 1 , wherein one or more of the overlapping junctions comprises an aperture extending therethrough, the aperture configured to communicate exudate from the treatment site. 
     
     
       3. The device of  claim 2 , wherein each of the plurality of holes and corresponding overlapping junctions are oval-shaped. 
     
     
       4. The device of  claim 3 , wherein a first of the plurality of oval-shaped junctions is oriented perpendicular with an adjacent second junction. 
     
     
       5. The device of  claim 2 , wherein the water-permeable layer comprises a plurality of perforations. 
     
     
       6. The device of  claim 1 , wherein the water-permeable layer comprises glass, polymers, hydrophilic materials, cellulose, polyglucose, polyacrylonitrile, polykeratin, polydimethylsiloxane, polyester, polyurethane, polyfibrin, xerogel, silicone, alginate, collagen, foams, hydrocolloid, hydrogels, polyglucose, lauryl polyglucose, polydimethylsiloxane, polyacrylate, polyacrylonitrile, polykeratin, siloxane, poly(lactic-co-glycolic acid), neoprene, sorbothane, polychloroprene, polyamide, polyimide, polyethylene glycol, polypropylene oxide, polymethlyacrylate, polyvinyl, polydextrin, alginate, polyisobutylene tackifiers, carboxymethyl cellulose, alginate, gelatin, agarose, polyolefin copolymer, polyether block amide, polyethylene, Nylon, polyethylene terephthalate, or a combination thereof. 
     
     
       7. The device of  claim 1 , wherein the fibrous holding layer comprises cellulose, fabric, polyglucose, polyacrylonitrile, polykeratin, polydimethylsiloxane, polyester, polyurethane, polyfibrin, poly-para-phenylene terephthalamide, cotton, flax, hemp, or a combination thereof and the gas-donor composition embedded therein. 
     
     
       8. The device of  claim 1 , wherein the gas-donor composition is selected from the group consisting of: diazeniumdiolated diamine, S-nitroso-albumin, S-nitroso-N penicillamine (SNAP), S-nistrosocystine (CysNO), S-nitrosoglutathione (GSNO), diazeniumdiolated dibutylhexyldiamine (DBHD N2O2), Diethylenetriamine/NO adduct (DEAT/NO), Diethylamine NONOate (DEA/NO), Dipropylenetriamine NONOate (DPTA/NO), 6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine (MAHMA/NO), S-nitroso-N-acetylpenicillamine, a polymer possessing an appended SNAP species, or a combination thereof. 
     
     
       9. The device of  claim 1 , wherein the therapeutic gas comprises: NO, O 2 , CO 2 , H 2 S, H 2 , or CO. 
     
     
       10. The device of  claim 1 , wherein the gas-permeable layer comprises polymer, hydrophilic materials, cellulose, polyglucose, polyacrylonitrile, polykeratin, polydimethylsiloxane, polyester, polyurethane, polyfibrin, xerogel, silicone, alginate, collagen, foams, hydrocolloid, hydrogels, polyglucose, lauryl polyglucose, polydimethylsiloxane, polyacrylonitrile, polykeratin, siloxane, poly(lactic-co-glycolic acid), neoprene, sorbothane, polychloroprene, polyamide, polyimide, polyethylene glycol, polypropylene oxide, polymethlyacrylate, polyvinyl, polydextrin, alginate, polyisobutylene tackifiers, carboxymethyl cellulose, alginate, gelatin, agarose, polyolefin copolymer, polyether block amide, polyethylene, Nylon, polyethylene terephthalate or a combination thereof. 
     
     
       11. The device of  claim 1 , further comprising one or a plurality of scavengers embedded in the fibrous holding layer, each of the scavengers being adapted to capture and remove gas byproducts. 
     
     
       12. The device of  claim 1 , wherein the water-permeable layer comprises a blister-layer, the blister-layer comprising an outer layer and an inner layer sealed at a periphery thereof and encapsulating a volume of water therein, the outer layer configured with one or more puncture elements for puncturing the inner layer upon receiving a puncturing force and for releasing the volume of water therethrough. 
     
     
       13. The device of  claim 1 , wherein the fibrous holding layer is devoid of water. 
     
     
       14. The device of  claim 1 , wherein the gas-donor composition comprises an inactive state. 
     
     
       15. A method of making a device for providing therapeutic gas to a subject at a treatment site, the method comprising:
 dissolving a therapeutic gas donor material in a solvent to form a solution; 
 soaking a fibrous holding layer in the solution; 
 evaporating the solvent from the fibrous holding layer to leave the therapeutic gas donor material embedded therein; 
 cutting a plurality of holes in the fibrous holding layer; 
 applying a water-permeable layer to the fibrous holding layer at a first side thereof, 
 applying a gas-permeable layer to the fibrous holding layer at a second side thereof opposite the first side; 
 applying a force to sandwich the combination of said layers, the force creating overlapping junctions where the water-permeable layer and the gas-permeable layer meet at the holes of the fibrous holding layer; and 
 cutting a plurality of apertures, each of the plurality of apertures being independently disposed at one of the overlapping junctions. 
 
     
     
       16. The method of  claim 15 , wherein said cutting the holes or cutting the apertures is performed using a laser cutting instrument. 
     
     
       17. The method of  claim 15 , wherein the solvent comprises an alcohol. 
     
     
       18. The method of  claim 15 , further comprising: cutting perforations in the water-permeable layer.