Anti-transferrin receptor antibodies and uses thereof

Abstract

The present disclosure provides anti-transferrin receptor antibodies, compositions comprising the same and methods of their use. This disclosure also provides polynucleotides and vectors encoding the anti-transferrin receptor antibodies and cells comprising the same, methods of making the antibodies, and molecules comprising the antibodies.

What is claimed is: 
     
       1. An antibody that binds to human transferrin receptor, comprising a heavy chain variable region (VH) comprising VH complementarity determining region (CDR)1, VH CDR2, and VH CDR3, wherein the antibody comprises a light chain variable region (VL) comprising VL CDR1, VL CDR2, and VL CDR3, and wherein the VH CDR1 comprises the amino acid sequence GIDFSSSGYMC (SEQ ID NO:101), the VH CDR2 comprises the amino acid sequence CIYTYSSNTYYAASVKG (SEQ ID NO:103), the VH CDR3 comprises the amino acid sequence GTYGYTGYTYTMGYFSL (SEQ ID NO:106), the VL CDR1 comprises the amino acid sequence QASQNINSYLA (SEQ ID NO:107), the VL CDR2 comprises the amino acid sequence RASSLES (SEQ ID NO:108), and the VL CDR3 comprises the amino acid sequence QSYYYSGSSNYNA (SEQ ID NO:110). 
     
     
       2. A pharmaceutical composition comprising the antibody of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
       3. A conjugate comprising the antibody of  claim 1 . 
     
     
       4. The antibody of  claim 1 , which is an Fab fragment or an Fab′ fragment. 
     
     
       5. An antibody that binds to human transferrin receptor, comprising a heavy chain variable region (VH) and a light chain variable region (VL), wherein the VH comprises the amino acid sequence of SEQ ID NO:16 and the VL comprises the amino acid sequence of SEQ ID NO:35. 
     
     
       6. The antibody of  claim 5 , which is an Fab fragment or an Fab′ fragment. 
     
     
       7. A pharmaceutical composition comprising the antibody of  claim 5  and a pharmaceutically acceptable carrier. 
     
     
       8. A conjugate comprising the antibody of  claim 5 . 
     
     
       9. An antibody that binds to human transferrin receptor, comprising a heavy chain comprising the amino acid sequence set forth in SEQ ID NO:95, and a light chain comprising the amino acid sequence set forth in SEQ ID NO:96. 
     
     
       10. A pharmaceutical composition comprising the antibody of  claim 9  and a pharmaceutically acceptable carrier. 
     
     
       11. A conjugate comprising the antibody of  claim 9 .