US11865108B2ActiveUtilityA1
Nitrogen containing bicyclic compounds

Assignee: WOCKHARDT LTDPriority: Oct 18, 2019Filed: Oct 18, 2020Granted: Jan 9, 2024
Est. expiryOct 18, 2039(~13.3 yrs left)· nominal 20-yr term from priority
Inventors:Vijaykumar Jagdishwar Patil Ravikumar Tadiparthi Rajib Bhuniya Vikas Vitthalrao Deshmukh Zaki Ahmed Burhanuddin Munshi Piyush Ambalal Patel Prashant Joshi Rajesh Chavan Swapna Shripad Takalkar Ravindra Dattatraya Yeole Mahesh Vithalbhai Patel
A61K 31/439A61K 31/546A61P 31/04C07D 471/08
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Claims
Abstract

Nitrogen containing bicyclic compounds of Formula (I), pharmaceutical compositions comprising these compounds and their use in treating bacterial infection is disclosed.
Claims

exact text as granted — not AI-modified
We claim: 
     
       1. A compound of Formula (I), or a stereoisomer or a pharmaceutically acceptable salt thereof: 
       
         
           
           
               
               
           
         
         wherein: 
         B is selected from:
 (a) hydrogen, 
 (b) halogen, 
 (c) C 1 -C 6  alkyl, 
 (d) OR 1 , 
 (e) NR 1 R 2 , 
 (f) SH, 
 (g) SR 1 , 
 (h) SOR 1 , 
 (i) SO 2 R 1 , 
 (j) CHO, 
 (k) COOR 1 , 
 (l) CONR 1 R 2 , 
 (m) CN, 
 (n) heteroaryl, 
 (o) heterocycloalkyl, or 
 (P) NHC(═NH)NH 2 ; 
 
         R 1  and R 2  are each independently:
 (a) hydrogen, 
 (b) C 1 -C 6  alkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH 2 , COOH, CONH 2 , SH, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, 
 (c) three to seven membered cycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH 2 , COOH, CONH 2 , or SH, 
 (d) three to seven membered heterocycloalkyl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH 2 , COOH, CONH 2 , or SH, 
 (e) six to fourteen membered aryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH 2 , COOH, CONH 2 , or SH, or 
 (f) five to fourteen membered heteroaryl, optionally substituted with one or more substituents independently selected from CN, halogen, OH, NH 2 , COOH, CONH 2 , SH; 
 
         M is selected from:
 (a) hydrogen, 
 (b) C 1 -C 6  alkyl, or 
 (c) a pharmaceutically accepted salt forming cation independently selected from Na, K, or Ca. 
 
       
     
     
       2. The compound according to  claim 1 , selected from:
 (2S,5R)—N-{[(2S,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 2S,5R)—N-{[(2S,4S)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 (2S,5R)—N-{[(2S,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 (2S,5R)—N-{[(2R,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 (2S,5R)—N-{[(2R,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 (2S,5R)—N-{[(2S,4R)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 2S,5R)—N-{[(2S,4S)-4-Cyanomethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-1,2,4,triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-(2H-tetrazoyl-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2S,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 (2S,5R)—N-{[(2R,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 or a stereoisomer or a pharmaceutically acceptable salt thereof. 
 
     
     
       3. The compound according to  claim 1 , selected from:
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Methyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of 2S,5R)—N-{[(2S,4S)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Hydroxymethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Hydroxymethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Aminomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide trifluoroacetate salt; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of 2S,5R)—N-{[(2S,4S)-4-Cyanomethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Cyanomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Cyanomethy-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1, 6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Fluoromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Chloromethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Mercaptomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Aziridin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Azetidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Pyrrolidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Piperidin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Azepan-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Piperazin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(Morpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(Thiomorpholin-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-Pyrrol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-imidazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-pyrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-1,2,3-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-1,2,4-triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-1,2,4,triazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(1H-tetrazol-1-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-(2H-tetrazoly-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-(2H-tetrazol-2-ylmethyl)-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2S,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4S)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 Sodium salt of (2S,5R)—N-{[(2R,4R)-4-Carbamimidomethyl-pyrrolidin-2-yl]methyloxy}-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; 
 or a stereoisomer. 
 
     
     
       4. The compound according to  claim 1 , selected from: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
       5. A pharmaceutical composition comprising a compound according to  claim 1 . 
     
     
       6. The pharmaceutical composition according to  claim 5 , further comprising at least one antibacterial agent or a pharmaceutically acceptable salt thereof. 
     
     
       7. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is a beta-lactam antibacterial agent. 
     
     
       8. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is at least one selected from a group consisting of Ansamycin, Carbacephem, Carbapenam, Carbapenem, Cephalosporin, Cephamycin, Cephem, Lincosamide, Lipopeptide, Macrolide, Ketolide, Monobactam, Nitrofuran, Oxacephem, Oxapenam, Oxazolidinone, Penam, Penem, Penicillin, Polypeptide, Quinolone, Sulfonamide, or Tetracycline antibacterial agents. 
     
     
       9. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is at least one selected from a group consisting of cefacetrile, cefaclor, cefadroxil, cefalexin, cefaloglycin, cefalonium, cefaloridine, cefalotin, cefamandole, cefapirin, cefatrizine, cefazaflur, cefazedone, cefazolin, cefbuperazone, cefcapene, cefclidin, cefdaloxime, cefdinir, cefditoren, cefepime, cefetamet, cefixime, cefluprenam, cefmenoxime, cefmetazole, cefminox, cefodizime, cefonicid, cefoperazone, ceforanide, cefoselis, cefotaxime, cefotetan, cefotiam, cefovecin, cefoxitin, cefoxitin, cefozopran, cefpimizole, cefpiramide, cefpirome, cefpodoxime, cefprozil, cefquinome, cefradine, cefroxadine, cefsulodin, ceftaroline, ceftazidime, cefteram, ceftezole, ceftibuten, ceftiofur, ceftiolene, ceftizoxime, ceftobiprole, ceftolozane, ceftriaxone, cefuroxime, cefuzonam, cephaloridine, cephradine, cefiderocol, flomoxef, latamoxef, loracarbef, moxalactam, or a pharmaceutically acceptable salt thereof. 
     
     
       10. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is at least one selected from a group consisting of cefaclor, cefadroxil, cefalexin, cefdinir, cefixime, cefpirome, cefpodoxime, cefprozil, cefradine, ceftibuten, cefuroxime, loracarbef, or a pharmaceutically acceptable salt thereof. 
     
     
       11. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is at least one selected from a group consisting of ertapenem, doripenem, imipenem, meropenem, panipenem, biapenem, tebipenem, lenapenem, tomopenem, or a pharmaceutically acceptable salt thereof. 
     
     
       12. The pharmaceutical composition according to  claim 6 , wherein the antibacterial agent is at least one selected from a group consisting of cefpodoxime axetil, cefpodoxime proxetil, ceftibuten, cefuroxime, cefuroxime axetil, cefixime, or a pharmaceutically acceptable salt thereof. 
     
     
       13. A method for treating or preventing bacterial infection in a subject, said method comprising administering to said subject a compound according to  claim 1 . 
     
     
       14. A method for treating or preventing bacterial infection in a subject, said method comprising administering to said subject a pharmaceutical composition according to  claim 5 .
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