Composition for hard tissue repair and kit for hard tissue repair

Abstract

Disclosed are: a composition for hard tissue repair with excellent penetrability to an adherend such as a cancellous bone and excellent adhesion to an adherend, which comprises a monomer (A), a polymer (B), a polymerization initiator (C) and a contrast medium (X) having a volume mean particle diameter of 3 μm or more; and a kit for hard tissue repair having members in which the components of the monomer (A), the polymer (B), the polymerization initiator (C) and the contrast medium (X) contained in this composition for hard tissue repair are encased in three or more divided groups in an optional combination.

The invention claimed is: 
     
       1. A composition for hard tissue repair comprising a monomer (A), a polymer (B), a polymerization initiator (C) and a contrast medium (X) having a volume mean particle diameter of 3 μm or more,
 wherein the monomer (A) is a methyl methacrylate, 
 wherein the polymer (B) comprises:
 a polymer powder (b1) having a specific surface area of 0.05 to 0.5 m 2 /g, and, 
 a polymer powder (b2) having a specific surface area of 0.51 to 1.2 m 2 /g and/or a polymer powder (b3) of particles having a specific surface area of 1.5 to 4.5 m 2 /g, 
 wherein the initiator (C) is a partially oxidized trialkylboron which contains ethanol but does not contain an aprotic solvent, and 
 wherein a volume mean particle diameter of all particles contained in the composition for hard tissue repair is 15 to 26 μm. 
 
 
     
     
       2. The composition for hard tissue repair according to  claim 1 , wherein the contrast medium (X) is barium sulfate or zirconia. 
     
     
       3. The composition for hard tissue repair according to  claim 1 , wherein the polymer (B) is a (meth)acrylate-based polymer. 
     
     
       4. The composition for hard tissue repair according to  claim 1 , comprising 10 to 45 parts by mass of the monomer (A), 54.9 to 80 parts by mass of the polymer (B) and 0.1 to 10 parts by mass of the polymerization initiator (C) (the sum of the components (A) to (C) is taken as 100 parts by mass), and 0.5 to 70 parts by mass of the contrast medium (X). 
     
     
       5. The composition for hard tissue repair according to  claim 1 , wherein the volume mean particle diameter of the contrast medium (X) is 3.0 to 25.1 μm. 
     
     
       6. A kit for hard tissue repair comprising three or more members, in which each of the components of the monomer (A), the polymer (B), the polymerization initiator (C) and the contrast medium (X) of the composition for hard tissue repair according to  claim 1  are divided and contained in the members in an optional combination.