Preoperative planning method for multimodal ablation treatment and apparatus thereof

Abstract

The present application relates to computer-based preoperative planning technology, and discloses a preoperative planning method for multimodal ablation treatment and apparatus thereof, which can automatically provide objective, scientific, and quantitative multimodal ablation planning information. In this method, acquiring parameters of an volume to be ablated; calculating property changes of the tissue caused by performing freezing on the volume according to the parameters of the volume to be ablated, and acquiring a first planning data required for the property changes of the tissue to satisfy a first predetermined condition; further calculating property changes of the tissue caused by performing heating on the volume to acquire a second planning data required for the property changes of the tissue to satisfy a second predetermined condition based on the properties satisfying the first predetermined condition; outputting the first planning data and the second planning data.

What is claimed is: 
     
       1. A preoperative planning method for multimodal ablation treatment, comprising:
 acquiring, by one or more processors via an input device, one or more parameters of a volume to be ablated, wherein the volume to be ablated comprises a tumor; 
 calculating, by the one or more processors, a freezing dosage required for effecting one or more first property changes to tissue within the volume according to both mechanical and biological effect of the freezing on the tissue within the volume and the one or more parameters of the volume to be ablated; 
 acquiring, by the one or more processors, a first planning data required for the one or more first property changes to the tissue within the volume to satisfy a first predetermined condition; 
 calculating, by the one or more processors, based on coupling of electromagnetic field and temperature field and taking into account the first property changes to the tissue within the volume after freezing and a synergy among treatment needles, a corresponding heating rate and total thermal dose required for in-situ disruption of all cells and/or microvessels within a boundary of the tumor to maximize release of tumor antigens and stimulate the body's immune response based on the principle of biological heat and mass transfer and thermal energy induced biological effect; 
 acquiring, by the one or more processors, a second planning data required for one or more second property changes to the tissue within the volume caused by heating of the tissue within the volume to satisfy a second predetermined condition; and 
 outputting, by the one or more processors, the first planning data and the second planning data. 
 
     
     
       2. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the outputting of the first planning data and the second planning data, comprises:
 displaying, on a display, a needle insertion scheme for the multimodal ablation and/or resulting temperature field distribution in form of text and/or graphics according to the first planning data and the second planning data. 
 
     
     
       3. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the first predetermined condition is that the properties of the tissue within the volume reach a state capable of uniformly conducting heat in all directions. 
     
     
       4. The preoperative planning method for multimodal ablation treatment according to  claim 3 , wherein the properties of the tissue within the volume reach a state capable of uniformly conducting heat in all directions, comprises that an ice ball is formed in the volume to be ablated, and the ice ball covers the entire volume to be ablated. 
     
     
       5. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the one or more first and second property changes comprise one or any combination of the following change: change in electrical conductivity, change in thermal conductivity, change in electrolyte distribution, change in blood flow distribution. 
     
     
       6. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the first planning data comprises one or any combination of the following:
 patient posture, skin puncture point, number of treatment needles, position of treatment needles, insertion path of treatment needles, number and distance of treatment needles withdrawal, freezing power and time, freezing rate. 
 
     
     
       7. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the second planning data comprises one or any combination of the following:
 patient posture, skin puncture point, number of treatment needles, position of treatment needles, insertion path of treatment needles, number and distance of treatment needles withdrawal, heating power and time, heating rate. 
 
     
     
       8. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the one or more parameters of the volume to be ablated comprise one or any combination of the following:
 the size, shape, relative position and tissue property information of the tumor and other tissues and organs in the volume to be ablated, the blood vessel distribution and the blood perfusion situation of the surrounding tissues. 
 
     
     
       9. The preoperative planning method for multimodal ablation treatment according to  claim 8 , wherein the acquiring parameters of the volume to be ablated, comprises,
 performing reconstruction and segmentation according to a patient's preoperative 2D or 3D images, and extracting the size, shape, relative position and tissue property information of the tumor and other tissues and organs; acquiring the blood vessel distribution and the blood perfusion of the tumor and surrounding tissues by imaging methods. 
 
     
     
       10. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the calculating freezing dosage further comprises: calculating, considering the influence of the tissue within the volume, large blood vessels, and blood flow, the number of freezing needles required for tissue pretreatment and the synergy among the freezing needles to ensure that the ice ball covers the entire tumor; and calculating a freezing rate of forming the ice ball and setting the freezing power. 
     
     
       11. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the calculating the freezing dosage comprises acquiring the one or more first property changes of the tissue in the volume after freezing by calculating a freezing range and the temperature field. 
     
     
       12. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein the calculating corresponding heating rate and total thermal dose required for in-situ disruption of all cells and/or microvessels within the tumor boundary is followed by:
 changing a number and position distribution of the treatment needles, to ensure that the overlap degree between a heating range of the treatment needles and a freezing range of the treatment needles satisfies predetermined requirements. 
 
     
     
       13. The preoperative planning method for multimodal ablation treatment according to  claim 1 , wherein after the step of outputting the first planning data and the second planning data, further comprising:
 acquiring medical images of pre-inserted treatment needles; 
 calculating the number and position of the pre-inserted treatment needles according to the medical images of the pre-inserted treatment needles; 
 determining whether the number and position of the pre-inserted treatment needles are consistent with the first planning data and the second planning data; 
 if inconsistent, according to the number and position of the pre-inserted treatment needles, simulating the temperature field distribution of the tumor cells and action of mechanical force, calculating ablation volume formed by the pre-inserted needles, and revising planning parameters according to the calculated ablation volume, including increasing or decreasing the number of treatment needles, adjusting position distribution of the treatment needles, increasing or decreasing the heating power and time. 
 
     
     
       14. The preoperative planning method for multimodal ablation treatment according to  claim 13 , wherein after revising the planning parameters according to the calculated ablation volume, further comprising:
 if the thermal dose generated according to the revised planning parameters is insufficient to cause in situ disruption of tumor cells and/or microvessels within the tumor boundary, then re-planning multimodal ablation plan and revising ablation strategy to ensure complete local ablation of the tumor in the volume to be ablated. 
 
     
     
       15. A preoperative planning apparatus for multimodal ablation treatment, comprising:
 a memory for storing computer executable instructions; and, 
 a processor, configured to implement the steps of the preoperative planning method for multimodal ablation treatment according to  claim 1  when executing the computer executable instructions. 
 
     
     
       16. A computer readable storage medium, wherein the computer readable storage medium stores computer executable commands, which are executed by a processor to implement the steps in the method according to  claim 1 .