Method for removing organic solvent from starch hemostatic microspheres

Abstract

The present invention provides a method for removing an organic solvent from starch hemostatic microspheres, comprising the following steps: 1. taking to-be-dried starch hemostatic microspheres and laying them flatly on drying trays with attention to laying them as uniformly and thinly as possible; 2. taking an adsorbent and subpackaging it into dialyzing paper bags for sealing; and 3. placing the trays and the dialyzing paper bags completed in the previous two steps on separators of a low-temperature vacuum oven in layers, setting the oven temperature at 0-20° C., then vacuumizing and keeping pressure for 15-48 hours. The method provided by the present invention can reduce organic solvent residue in the starch hemostatic microspheres to less than 0.05%, which meets the requirements of relevant standards for medical devices, thereby improving safety of products.

The invention claimed is: 
     
       1. A method for removing an organic solvent from starch hemostatic microspheres, comprising the following steps:
 (1) laying the starch hemostatic microspheres flatly on drying trays; 
 (2) taking an adsorbent according to a mass ratio of 20% to 100% of the starch hemostatic microspheres, packaging the adsorbent into dialyzing paper bags, and sealing the dialyzing paper bags, wherein the adsorbent is an adsorbent capable of adsorbing organic gases contained in the starch hemostatic microspheres; and 
 (3) placing the drying trays loaded with the starch hemostatic microspheres obtained in step (1) and the sealed dialyzing paper bags obtained in step (2) within a low-temperature vacuum oven in layers, setting the oven temperature at 0-20° C., then vacuumizing the oven to a negative pressure of −0.1 to −0.05 MPa, and keeping the pressure of −0.1 to −0.05 MPa within the oven for 15-48 hours. 
 
     
     
       2. The method for removing the organic solvent from the starch hemostatic microspheres according to  claim 1 , wherein the adsorbent is a solid selected from the group consisting of activated carbon, molecular sieve, clay, metal-organic frameworks (MOFs) and polymeric adsorbent resin.