Method and system for delivering sensory simulation based on evoked response quantification

Abstract

A system for delivering sensory stimulation a sensor; a sensory stimulator configured to deliver sensory stimulation to a patient during a sleep session, the sensory stimulation having varying stimulation intensity levels; and a computer system. One or more physical processors being programmed with computer program instructions which, when executed cause the computer system to: determine sleep stage information of the patient based on brain activity information of the patient during the sleep session from the sensor; provide input to the sensory stimulator based on the determined sleep stage information of the patient, the provided input causing the sensory stimulator to deliver the sensory stimulation to the patient; obtain stimulation response information from the patient, the stimulation response information including patient brain response to the delivered sensory stimulation; and determine a range of the stimulation intensity levels within which the patient brain response reaches a threshold.

What is claimed is: 
     
       1. A system for delivering modulated sensory stimulation having varying stimulation intensity levels to a patient, comprising:
 a sensor configured to measure brain activity information of a-the patient during a sleep session; 
 a sensory stimulator configured to deliver sensory stimulation to the patient during the sleep session, the sensory stimulation being modulated sensory stimulation having varying stimulation intensity levels; and 
 a computer system that comprises one or more physical processors operatively connected with the sensor and the sensory stimulator, the one or more physical processors being programmed with computer program instructions which, when executed cause the computer system to: 
 determine sleep stage information of the patient based on the brain activity information of the patient during the sleep session; 
 cause the sensory stimulator to deliver the modulated sensory stimulation to the patient during the sleep session based on the determined sleep stage information of the patient; 
 obtain stimulation response information from the patient during the sleep session, the stimulation response information including patient brain response to the delivered modulated sensory stimulation; and 
 determine during the sleep session and based on the stimulation response information a minimum stimulation intensity level and a maximum stimulation intensity level, the minimum stimulation intensity level being a lowest level at which the delivered modulated sensory stimulation elicited a detectable patient brain response to the delivered modulated sensory stimulation and the maximum stimulation intensity level being a saturation level greater than the minimum intensity level at which the brain response of the patient brain response to the delivered modulated sensory stimulation has reached saturation, wherein the saturation level is an intensity level of the delivered modulated stimulation below which the patient brain response to the delivered modulated sensory stimulation changes and above which the patient brain response to the delivered modulated sensory stimulation does not change, and wherein the saturation level is below an intensity level that produces arousals in the patient. 
 
     
     
       2. The system of  claim 1 , wherein the stimulation response information includes a waveform, an amplitude of positive and/or negative peaks in the waveform, peak to peak distance in the waveform, an average amplitude of the waveform, latency of a number of successive peaks in the waveform, and an area under the waveform in a predefined interval. 
     
     
       3. The system of  claim 1 , wherein the modulated sensory stimulation is selected from the group consisting of olfactory stimulation, auditory stimulation, visual stimulation, touch stimulation, taste stimulation, and haptic stimulation. 
     
     
       4. A method for delivering modulated sensory stimulation having varying stimulation intensity levels to a patient, the method being implemented by a computer system that comprises one or more physical processors executing computer program instructions that, when executed, cause the computer system to perform the method, the method comprising:
 determining, using the computer system, sleep stage information of the patient based on brain activity information of the patient during a sleep session, the brain activity information of the patient during the sleep session being measured by a sensor; 
 causing a sensory stimulator to deliver the modulated sensory stimulation to the patient during the sleep session based on the determined sleep stage information of the patient; 
 obtaining stimulation response information from the patient during the sleep session, the stimulation response information including patient brain response to the delivered modulated sensory stimulation; and 
 determining during the sleep session, using the computer system, and based on the stimulation response information a minimum stimulation intensity level and a maximum stimulation intensity level, the minimum stimulation intensity level being a lowest level at which the delivered modulated sensory stimulation elicited a detectable patient brain response to the delivered modulated sensory stimulation and the maximum stimulation intensity level being a saturation level greater than the minimum intensity level at which the patient brain response to the delivered modulated sensory stimulation has reached saturation, wherein the saturation level is an intensity level of the delivered modulated stimulation below which the patient brain response to the delivered modulated sensory stimulation changes and above which the patient brain response to the delivered modulated sensory stimulation does not change, and wherein the saturation level is below an intensity level that produces arousals in the patient. 
 
     
     
       5. The method of  claim 4 , wherein the stimulation response information includes a waveform, an amplitude of positive and/or negative peaks in the waveform, peak to peak distance in the waveform, an average amplitude of the waveform, latency of a number of successive peaks in the waveform, and an area under the waveform in a predefined interval. 
     
     
       6. The method of  claim 4 , wherein the modulated sensory stimulation is selected from the group consisting of olfactory stimulation, auditory stimulation, visual stimulation, touch stimulation, taste stimulation, and haptic stimulation. 
     
     
       7. A system for delivering modulated sensory stimulation having varying stimulation intensity levels to a patient, the system comprising:
 means for measuring brain activity information of the patient during a sleep session; 
 means for delivering the modulated sensory stimulation to the patient during the sleep session; and 
 means for executing machine-readable instructions with at least one processor, which, when executed, cause the system to execute a method the comprising: 
 determining sleep stage information of the patient based on the brain activity information of the patient during the sleep session; 
 causing the means for delivering to deliver the modulated sensory stimulation to the patient during the sleep session based on the determined sleep stage information of the patient; 
 obtaining stimulation response information from the patient during the sleep session, the stimulation response information including patient brain response to the delivered modulated sensory stimulation; and 
 determining during the sleep session and based on the stimulation response information a minimum stimulation intensity level and a maximum stimulation intensity level, the minimum stimulation intensity level being a lowest level at which the delivered modulated sensory stimulation elicited a detectable patient brain response to the delivered modulated sensory stimulation and the maximum stimulation intensity level being a saturation level greater than the minimum intensity level at which the patient brain response to the delivered modulated sensory stimulation reached saturation, wherein the saturation level is an intensity level of the delivered modulated stimulation below which the patient brain response to the delivered modulated sensory stimulation changes and above which the patient brain response to the delivered sensory stimulation does not change, and wherein the saturation level is below an intensity level that produces arousals in the patient. 
 
     
     
       8. The system of  claim 7 , wherein the stimulation response information includes a waveform, an amplitude of positive and/or negative peaks in the waveform, peak to peak distance in the waveform, an average amplitude of the waveform, latency of a number of successive peaks in the waveform, and an area under the waveform in a predefined interval. 
     
     
       9. The system of  claim 7 , wherein the modulated sensory stimulation is selected from the group consisting of olfactory stimulation, auditory stimulation, visual stimulation, touch stimulation, taste stimulation, and haptic stimulation.