US12172975B2ActiveUtilityA1
1H-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (RIPK1)

Assignee: BRISTOL MYERS SQUIBB COPriority: Sep 13, 2018Filed: Sep 12, 2019Granted: Dec 24, 2024
Est. expirySep 13, 2038(~12.2 yrs left)· nominal 20-yr term from priority
Inventors:Junqing Guo Jie Chen Carolyn Diane Dzierba Amy C. Hart Guanglin Luo John E. Macor William J. Pitts Sing-Yuen Sit
C07D 405/14C07D 401/14C07B 2200/05A61P 9/04A61P 19/02A61P 17/06A61P 1/00A61P 29/00A61K 31/4439C07D 401/04
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Claims
Abstract

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, (I) are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.
Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. Compounds having formula (I), or salt thereof, wherein 
       
         
           
           
               
               
           
         
         R a  is H, halo, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  deuteroalkyl, C 1-4  deuteroalkoxy, cyclopropyl, or N(R e ) 2 : 
         R b  is H, halo, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  deuteroalkyl, C 1-4  deuteroalkoxy, halo, or N(R e ) 2 ; 
         R c  is H, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  deuteroalkyl, or halo; 
         R d  is independently H, halo, or C 1-3  alkyl; 
         R e , is independently at each occurrence, H, C 1-4  alkyl, or C 1-4  deuteroalkyl; 
         R 1  is C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  deuteroalkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl, C 0-3  alkyl-heterocycle, wherein the heterocycle is a 3 to 6 membered ring having 1-3 heteroatoms selected from N, S and O, and wherein the alkyl, cycloalkyl, phenyl, or heterocycle are independently substituted with 0-2 of =O, halo, OH, C 1-3  alkyl, C 1-3  deuteroalkyl, —C(O)—C 1-3  alkyl, —SO 2 —C 1-3  alkyl, —N(R 1e ) 2 , phenyl, or phenyl-O—C 1-3  alkyl; 
         R 1e , is independently at each occurrence, H, C 1-4  alkyl, or C 1-4  deuteroalkyl; 
         L is —C(O)NR e —; and 
         A is A 1  or -A 1 -L 1 -, wherein A 1  is C 1-6  alkyl substituted with 0-1 OH, C 1-6  deuteroalkyl substituted with 0-1 OH, C 1-6  haloalkyl substituted with 0-1 OH, C 1-6  deuteroalkyl, C 1-6  haloalkyl, C 0-3  alkyl-C 3-10  cycloalkyl-C 0-3 -alkyl, C 0-3 -alkyl-phenyl, C 0-3 -alkyl-heterocycle, wherein the heterocycle is a 3 to 6 membered ring having 1-3 heteroatoms selected from N, S and O, and wherein the cycloalkyl, phenyl and heterocycle are substituted with 0-2 R 8 ; 
         L 1  is —O—, —S—, —C(O)—, —C(O)NR e , —SO 2 NH—, —NHSO 2 —, —C(O)O—, —NR e —C(O)—, —NR e —C(O)O—, —NR e —C(O)NR e —, —SO 2 —, or —NH—R e —; 
         or alternatively, -L-A- is 
       
       
         
           
           
               
               
           
         
         R 2  is C 1-6  alkyl, C 1-6  haloalkyl, C 0-3 alkyl-C 6-10  aryl, C 0-3 alkyl-C 3-6  cycloalkyl, or a C 0-3 alkyl-3 to 6 membered heterocycle having 1-4 heteroatoms selected from N, S and O, wherein any of the aryl, cycloalkyl, or heterocycle groups are substituted with 0-3 R 2a ; 
         R 2a  is halo, CN, =O, C 1-6  alkyl, C 1-6  alkoxy, hydroxy-C 1-6  alkoxy, C 1-6  deuteroalkyl, C 1-6  deuteroalkoxy, C 1-6  haloalkyl, C 1-6  haloalkoxy, C 0-3  alkyl-C 3-6  cycloalkyl-C 0-3  alkyl, C 3-6  halocycloalkyl, C 3-6  cycloalkoxy, C 3-6  cycloalkyl-C 1-6  alkoxy, C 6-10  aryl, phenyl-C 1-3  alkoxy-, C 3-6  cycloalkyl-C 1-3  deuteroalkoxy-, C 3-6  cycloalkyl-C 1-3  haloalkoxy-, C 1-6  alkoxy-C 1-3  alkyl-, C 3-6  cycloalkoxy-C 1-3  alkyl-, C 6-10  aryl-O—, phenyl C 1-4  alkyl-SO 2 —, C 3-6  cycloalkyl-SO 2 —, C 6-10  aryl-S—, NR 6 R 6 CO—, NHR 6 —(CH 2 ) n —, R 5 —C(O)—, R 5 —OC(O)—, R 5 —C(O)O—, R 6 —NH—C(O)O—, R 7 —OC(O)NH—, R 6 —NH—C(O)NR 6 , R 7 —SO 2 —, R 5 —SO 2 NH—, R 5 —NHSO 2 —, heterocycle, heterocycle-O—, or heterocycle-C 0-6  alkyl-, wherein each heterocycle is independently a 4-6 membered ring having 1-2 heteroatoms selected from N, S and O, and wherein each alkyl, cycloalkyl, phenyl, or heterocycle is substituted with 0-3 R 2b ; 
         R 2b , at each occurrence, is independently halo, OH, C 1-3  alkyl, C 1-3  alkoxy, hydroxy-C 1-3  alkoxy, hydroxy-C 1-3  alkyl, C═O, C 1-3  haloalkyl, or C 1-3  haloalkoxy; 
         R 5  is, independently at each occurrence, H, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl or C 1-6  haloalkyl; 
         R 6  is, independently at each occurrence, H, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl; 
         R 7  is, independently at each occurrence, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl; 
         R 8  is, independently at each occurrence, H, halo, C═O, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  haloalkyl, C 3-6  cycloalkyl, phenyl, a 3 to 6 membered heterocycle, —(CH 2 ) n —NR 6 R 6 CO, —(CH 2 ) n —NR 6 R 6 CONR 6 R 6 , —(CH 2 ) n —NR 6 , —(CH 2 ) n —C(O)—R 5 , —(CH 2 ) n —C(O)O—R 5 , —(CH 2 ) n —OC(O)—R 5 , —(CH 2 ) n —OC(O)—NH—R 6 , —(CH 2 ) n —NHC(O)—O—R 7 , —(CH 2 ) n —SO 2 —R 7 , —(CH 2 ) n —SO 2 NH—R 5 , —(CH 2 ) n —NHSO 2 —R 5 , wherein each heterocycle is independently a 4-6 membered ring having 1-2 heteroatoms selected from N, S and O; and 
         n is 0, 1, or 2. 
       
     
     
       2. A compound of  claim 1 , or salt thereof, wherein
 R a  is H, Cl, F, Br, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  deuteroalkyl, C 1-4  deuteroalkoxy, cyclopropyl, or N(R e ) 2 : 
 R b  is H, F, Cl, Br, C 1-4  alkyl, C 1-4  alkoxy, C 1-4  haloalkyl, C 1-4  haloalkoxy, C 1-4  deuteroalkyl, C 1-4  deuteroalkoxy, or NR e   2 ; 
 R c  is H, C 1-4  alkyl, C 1-4  haloalkyl, C 1-4  deuteroalkyl, or halo; 
 R d  is independently H or F; 
 R e , is independently at each occurrence, H, C 1-4  alkyl, or C 1-4  deuteroalkyl; 
 R 1  is C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  deuteroalkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-piperidinyl, C 0-3  alkyl-pyrrolidinyl, C 0-3  alkyl-morpholinyl, C 0-3  alkyl-pyrrolidinyl, wherein the alkyl, cycloalkyl, piperidinyl, pyrrolidinyl, or morpholinyl are independently substituted with 0-2 of =O, halo, OH, C 1-3  alkyl, C 1-3  deuteroalkyl, phenyl, or phenyl-O—C 1-3  alkyl; 
 L is —C(O)NR e —; and 
 A is A 1  or -A 1 -L 1 -, wherein A 1  is C 1-6  alkyl substituted with 0-1 OH, C 1-6  deuteroalkyl substituted with 0-1 OH, C 1-6  haloalkyl substituted with 0-1 OH, C 1-6  deuteroalkyl, C 1-6  haloalkyl, C 0-3  alkyl-C 3-10  cycloalkyl-C 0-3 -alkyl, C 0-3 -alkyl-C 3-6  cycloalkyl-C 0-3 -alkyl, C 0-3 -alkyl-imidazolyl, C 0-3 -alkyl-pyrrolidinyl, C 0-3 -alkyl-tetrahydropyranyl, C 0-3 -alkyl-pyridinyl, wherein the pyrrolidinyl is substituted with 0-2 R 8 ; 
 L 1  is —O—, —C(O)—, —C(O)NR e , —SO 2 NH—, —C(O)O—, —NR e —C(O)—, —SO 2 —, or —N—R e —; 
 or alternatively, -L-A- is— 
 
       
         
           
           
               
               
           
         
         R 2  is C 1-6  alkyl, C 1-6  haloalkyl, C 0-3 alkyl-phenyl, C 0-3 alkyl-C 3-6  cycloalkyl, or a C 0-3 alkyl-3 to 6 membered heterocycle having 1-4 heteroatoms selected from N, S and O, wherein any of the phenyl or heterocycle groups are substituted with 0-3 R 2a ; 
         R 2a  is halo, CN, =O, C 1-6  alkyl, C 1-6  alkoxy, hydroxy-C 1-6  alkoxy, C 1-6  deuteroalkyl, C 1-6  deuteroalkoxy, C 1-6  haloalkyl, C 1-6  haloalkoxy, C 1-3  alkyl-C 3-6  cycloalkyl-C 0-3  alkyl, C 3-6  halocycloalkyl, C 3-6  cycloalkoxy, C 3-6  cycloalkyl-C 1-3  alkoxy-, C 3-6  cycloalkyl-C 1-3  deuteroalkoxy-, C 3-6  cycloalkyl-C 1-3  haloalkoxy-, C 1-6  alkoxy-C 1-3  alkyl-, C 3-6  cycloalkoxy-C 1-3  alkyl-, phenyl-O—, C 1-4  alkyl-SO 2 —, C 3-6  cycloalkyl-SO 2 —, C 6-10  aryl-S—, NR 6 R 6 CO—, NHR 6 —(CH 2 ) n —, R 5 —C(O)—, R 6 —NH—C(O)O—, R 7 —OC(O)NH—, R 7 —SO 2 —, R 5 —SO 2 NH—, heterocycle-, heterocycle-O—, heterocycle-CH 2 —, wherein each heterocycle is independently a 4-6 membered ring having 1-2 heteroatoms selected from N, S and O, and wherein each alkyl, cycloalkyl, phenyl, or heterocycle is substituted with 0-3 R 2b ; 
         R 2b , at each occurrence, is independently C 1-3  alkyl, C 1-3  alkoxy, hydroxy-C 1-3  alkoxy, halo, C=O, C 1-3  haloalkyl, or C 1-3  haloalkoxy; 
         R 5  is, independently at each occurrence, H, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl; 
         R 6  is, independently at each occurrence, H, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl; 
         R 7  is, independently at each occurrence, H, C 1-6  alkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-phenyl; 
         R 8  is F, =O or C 1-3  alkyl, and 
         n is 0, 1, or 2. 
       
     
     
       3. A compound of  claim 1 , or salt thereof, wherein
 L is —C(O)NR e —; and 
 A is A 1  or -A 1 -L 1 -, wherein A 1  is C 1-6  alkyl substituted with 0-1 OH, C 1-6  deuteroalkyl substituted with 0-1 OH, C 1-6  haloalkyl substituted with 0-1 OH, C 1-6  deuteroalkyl, C 1-6  haloalkyl, C 0-3  alkyl-C 3-10  cycloalkyl-C 0-3 -alkyl, C 0-3 -alkyl-C 3-6  cycloalkyl-C 0-3 -alkyl, C 0-3 -alkyl-imidazolyl, C 0-3 -alkyl-pyrrolidinyl, C 0-3 -alkyl-tetrahydropyranyl, C 0-3 -alkyl-pyridinyl, wherein the B pyrrolidinyl is substituted with 0-2 R 8 . 
 
     
     
       4. A compound of  claim 3 , or salt thereof, wherein
 R a  is H, Cl, F, or C 1-4  alkyl, C 1-4  alkoxy or C 1-4  deuteroalkoxy; 
 R b  is H, C 1-3  alkyl, or C 1-3  alkoxy; and 
 R c  is H, or C 1-4  alkyl. 
 
     
     
       5. A compound of  claim 4 , or salt thereof, wherein
 A 1  is C 1-6  alkyl substituted with 0-1 OH, C 1-6  deuteroalkyl substituted with 0-1 OH, or C 0-3  alkyl-C 3-6  cycloalkyl; and 
 L 1  is —O—, —C(O)—, —C(O)NR e —, or —SO 2 NH—. 
 
     
     
       6. A compound of  claim 5 , or salt thereof, wherein
 R a  is H, C 1-4  alkyl, C 1-4  alkoxy or C 1-4  deuteroalkoxy; 
 R b  is H, or C 1-3  alkyl; and 
 R c  is H. 
 
     
     
       7. A compound of  claim 6 , or salt thereof, wherein
 R 1  is C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  deuteroalkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-piperidinyl, C 0-3  alkyl-pyrrolidinyl, C 0-3  alkyl-morpholinyl, C 0-3  alkyl-pyrrolidinyl, wherein the alkyl, cycloalkyl, piperidinyl, pyrrolidinyl, or morpholinyl are independently substituted with 0-2 of =O, halo, OH, C 1-3  alkyl, C 1-3  deuteroalkyl, or N(R 1e ) 2 . 
 
     
     
       8. A compound of  claim 6 , or salt thereof, wherein
 R 1  is C 1-3  alkyl, C 1-3  deuteroalkyl, or C 0-1  alkyl-cyclopropyl; 
 R 2  is C 1-6  alkyl, phenyl, (CH 2 ) n —C 3-6  cycloalkyl, or a (CH 2 ) n -3 to 6 membered heterocycle, wherein the heterocycle is selected from morpholinyl, tetrahydro-2H-pyranyl, or pyrrolidinyl, wherein any of the phenyl or heterocycle groups are substituted with 0-3 R 2a ; and 
 R 2a  is F, Cl, CN, ═O, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  deuteroalkyl, C 1-3  deuteroalkoxy, C 1-2 haloalkyl, C 1-3  alkyl-C 3-6  cycloalkyl-C 0-3  alkyl, C 3-6  cycloalkoxy, C 3-6  cycloalkyl-C 1-3  alkoxy-, C 3-6  cycloalkyl-C 1-3  deuteroalkoxy-, C 3-6  cycloalkoxy-C 1-3  alkyl-, phenyl, C 1-4  alkyl-SO 2 —, C 3-6  cycloalkyl-SO 2 —, NR 6 R 6 CO—, NHR 6 —(CH 2 ) n —, R 5 —C(O)—, R 6 —OC(O)—NH—, R 7 —NHC(O)—O—, R 7 —SO 2 —, R 5 —SO 2 NH—, —(CH 2 ) n -piperizinyl, —(CH 2 ) n -morpholinyl, wherein each alkyl, cycloalkyl, phenyl, or heterocycle is substituted with 0-3 R 2b . 
 
     
     
       9. A compound of  claim 1 , or salt thereof, wherein
 L-A- is — 
 
       
         
           
           
               
               
           
         
       
     
     
       10. A compound of  claim 9 , or salt thereof, wherein
 R a  is H, Cl, F, or C 1-4  alkyl, C 1-4  alkoxy or C 1-4  deuteroalkoxy; 
 R b  is H, C 1-3  alkyl, or C 1-3  alkoxy; and 
 R c  is H, or C 1-4  alkyl; 
 R 1  is C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  deuteroalkyl, C 0-3  alkyl-C 3-6  cycloalkyl, C 0-3  alkyl-piperidinyl, C 0-3  alkyl-pyrrolidinyl, C 0-3  alkyl-morpholinyl, C 0-3  alkyl-pyrrolidinyl, wherein the alkyl, cycloalkyl, piperidinyl, pyrrolidinyl, or morpholinyl are independently substituted with 0-2 of =O, halo, OH, C 1-3  alkyl, C 1-3  deuteroalkyl, or N(R 1e ) 2 ; 
 R 2  is C 0-3 alkyl-phenyl, C 0-3 alkyl-C 3-6  cycloalkyl, or a C 0-3 alkyl-3 to 6 membered heterocycle, wherein the heterocycle is selected from morpholinyl, tetrahydro-2H-pyranyl, or pyrrolidinyl, wherein any of the phenyl or heterocycle groups are substituted with 0-3 R 2a ; and 
 R 2a  is F, Cl, CN, ═O, C 1-6  alkyl, C 1-6  alkoxy, C 1-6  deuteroalkyl, C 1-3  deuteroalkoxy, C 1-2 haloalkyl, C 1-3  alkyl-C 3-6  cycloalkyl-C 0-3  alkyl, C 3-6  cycloalkoxy, C 3-6  cycloalkyl-C 1-3  alkoxy-, C 3-6  cycloalkyl-C 1-3  deuteroalkoxy-, C 3-6  cycloalkoxy-C 1-3  alkyl-, phenyl C 1-4  alkyl-SO 2 —, C 3-6  cycloalkyl-SO 2 —, NR 6 R 6 CO—, NR 6 —(CH 2 ) n —, R 5 —C(O)—, R 6 —OC(O)—NH—, R 7 —NHC(O)—O—, R 7 —SO 2 —, R 5 —SO 2 NH—, —(CH 2 ) n -piperizinyl, or —(CH 2 ) n -morpholinyl, wherein each alkyl, cycloalkyl, phenyl, or heterocycle is substituted with 0-3 R 2b . 
 
     
     
       11. A compound of  claim 1 , or salt thereof, wherein the compound is selected from:
 N-[(1,1,2,2,2-deuteroethyl]-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 (R)—N-(ethyl-d5)-6-(6-(methoxy-d3)-5-((1-(2-(trifluoromethoxy)phenyl)ethyl) carbamoyl)pyridin-3-yl)-1H-indazole-3-carboxamide; 
 (R)-6-(6-(methoxy-d3)-5-((1-(3-(trifluoromethyl)phenyl)ethyl)carbamoyl)pyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 (R)-6-(5-((1-(2-fluoro-5-(trifluoromethyl)phenyl)ethyl-2,2,2-d3)carbamoyl)-6-(methoxy-d3)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 (S)-6-(5-((1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl)carbamoyl)-6-(methoxy-d3)pyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 (R)-6-(5-((1-(2-fluoro-5-(trifluoromethyl)phenyl) ethyl)carbamoyl)-6-(methoxy-d3)pyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 (R)-6-(6-(methoxy-d3)-5-((1-(2-(trifluoromethoxy)phenyl) ethyl)carbamoyl)pyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 (R)-6-(6-(methoxy-d3)-5-((1-(3-(trifluoromethoxy) phenyl)ethyl)carbamoyl)pyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 (R)-6-(5-((1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)carbamoyl)-6-(methoxy-d3)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 (S)-6-(5-((1-(2-fluoro-5-(trifluoromethoxy)phenyl)ethyl-2,2,2-d3)carbamoyl)-6-(methoxy-d3)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 (R)-6-(6-(methoxy-d3)-5-((1-(3-(trifluoromethoxy)phenyl) ethyl-2,2,2-d3)carbamoyl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-(((3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl)carbamoyl)-6-methoxy d3-pyridin-3-yl)-N-methyl d3-1H-indazole-3-carboxamide; 
 (R)—N-cyclopropyl-6-(6-methoxy d3-5-((1-(2-(trifluoromethoxy)phenyl)ethyl)carbamoyl)pyridin-3-yl)-1H-indazole-3-carboxamide; 
 (R)-6-(6-methoxy d3-5-((1-(3-(trifluoromethoxy)phenyl) ethyl)carbamoyl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy d3-5-((1-(2-(trifluoromethoxy)phenyl)ethyl)carbamoyl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy D3-5-((2-(trifluoromethoxy)benzyl D2) carbamoyl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-((3-pivalamidocyclohexyl)carbamoyl) pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-(2-(1-phenylpropyl)-2H-tetrazol-5-yl)pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-(2-(1-(4-fluorophenyl)ethyl)-2H-tetrazol-5-yl)-6-methoxypyridin-3-yl)-N-(methyl-d3)-1H-indazole-3-carboxamide; 
 6-[5-(2-benzyl-2H-1,2,3,4-tetrazol-5-yl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[(3-phenylcyclohexyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 (rac)-N-isopropyl-6-(6-methoxy d3-5-((1-(2-(trifluoromethoxy)phenyl)ethyl)carbamoyl)pyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-(4-(dimethyl d6-amino)cyclohexyl)-6-(6-methoxy d3-5-((1-(3-(trifluoromethoxy)phenyl)ethyl)carbamoyl)pyridin-3-yl)-1H-indazole-3-carboxamide; 
 4-fluoro-6-[6-methoxy-5-({1-[2-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethoxy)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 3-{[2-(deutero)methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl]formamido}propanoate; 
 6-(5-{[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 3-{[2-(deutero)methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl]formamido}-2,2-dimethylpropanoate; 
 tert-butyl (3R)-3-{[2-(deutero)methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl]formamido}butanoate; 
 6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({1-[5-fluoro-2-(trifluoromethyl)phenyl]ethyl}carbamoyl)-6-(deutero)methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[(3-phenylbutyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-hydroxy-3-(4-methoxyphenyl)propyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(3,4-difluorophenyl)-3-hydroxypropyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(4-fluorophenyl)-3-hydroxypropyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(4-fluorophenyl)butyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(3-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[(1S,2S)-2-(4-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(1R,2S)-2-phenylcyclopropyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(1S,2R)-2-phenylcyclopropyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[2-(phenylsulfamoyl)ethyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(3-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide, cis; 
 6-[5-({[2-(3-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide, cis; 
 6-[5-({[4-fluoro-2-(oxan-4-yloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[(1S,2R)-2-phenylcyclopropyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[(1R,2S)-2-phenylcyclopropyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(morpholin-4-yl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{5-[({2-[(dimethylamino)methyl]phenyl}methyl)carbamoyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[(3-phenoxypropyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-{5-[(2-hydroxy-3-phenoxypropyl)carbamoyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-{5-[({2-[4-(hydroxymethyl)piperidin-1-yl]phenyl}methyl)carbamoyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(2-methoxyphenyl)methyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(2-methylpropoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(tert-butoxy)propyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[3-(oxan-2-yloxy)propyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(cyclohexyloxy)propyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(4-fluorophenoxy)propyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[3-(2-methylpropoxy)propyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(5-chloropyridin-2-yl)-3-hydroxypropyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2-methanesulfonylphenyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(1S,3R)-3-phenylcyclopentyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[1-(phenoxymethyl)cyclopropyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(propane-1-sulfonyl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[(1R,2R)-2-(4-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide, trans; 
 6-[5-({[1-(4-fluorophenyl)cyclopropyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[({1-[2-(trifluoromethoxy)phenyl]cyclopropyl}methyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl N-{2-[({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)methyl]phenyl}carbamate; 
 tert-butyl 3-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)propanoate; 
 6-[6-methoxy-5-({[2-(2,2,2-trifluoroethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-methoxy-5-(trifluoromethyl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl N-[(1R,2S)-2-[({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)methyl]cyclohexyl]carbamate; 
 6-[5-({[2-(difluoromethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(2-phenyloxan-3-yl)methyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(propane-2-sulfonyl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2,2-dimethylcyclohexyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2-ethylphenyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2-tert-butyloxan-3-yl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2-cyanophenyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclopropylsulfamoyl)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclobutylmethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[3-(2,2,2-trifluoroethoxy)cyclohexyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 ethyl 3-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)-2,2-dimethylpropanoate; 
 6-(5-{[(3,5-difluoro-2-methoxyphenyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 3-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)-2,2-dimethylpropanoate; 
 6-{5-[(2-{[(4-fluorophenyl)methyl]carbamoyl}-2,2-dimethylethyl)carbamoyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[3-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 -[6-methoxy-5-({[2-(propan-2-yloxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[(2-methoxypyridin-3-yl)methyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[(3-phenyladamantan-1-yl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[1-(3,3,3-trifluoro-2,2-dimethylpropanoyl)pyrrolidin-2-yl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[3-(morpholine-4-carbonyl)cyclohexyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(6-methoxy-5-{[3-(pyrrolidine-1-carbonyl)cyclohexyl]carbamoyl}pyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({1-[3-(trifluoromethyl)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[3-(trifluoromethyl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[2,2-difluoro-3-(propan-2-yloxy)propyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[4-fluoro-3-(trifluoromethyl)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({1-[4-fluoro-3-(trifluoromethyl)phenyl]ethyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[3-(cyclopropylmethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[3-(cyclopentyloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethyl)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({1-[2-(trifluoromethyl)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclopentylmethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[3-(propan-2-yloxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclobutylmethoxy)pyridin-3-yl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclohexyloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-fluoro-3-(trifluoromethyl)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[3-(cyclobutylmethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2,2-dimethylcyclopentyl)methyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[3-(cyclobutylmethoxy)pyridin-2-yl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[(3-phenoxycyclohexyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-fluoro-3-(trifluoromethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(dimethylcarbamoyl)cyclohexyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(diethylcarbamoyl)cyclohexyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({3-[ethyl(methyl)carbamoyl]cyclohexyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({3-[(cyclopropylmethyl)(propyl)carbamoyl]cyclohexyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({3-[(cyclobutylmethyl)(ethyl)carbamoyl]cyclohexyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({3-[cyclopropyl(methyl)carbamoyl]cyclohexyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[3,5-difluoro-2-(propan-2-yloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-fluoro-6-(propan-2-yloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclopropylmethoxy)-3,5-difluorophenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({1-[2-(trifluoromethyl)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[5-fluoro-2-(propan-2-yloxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{6-methoxy-5-[({2-[(3-methylcyclopentyl)oxy]phenyl}methyl)carbamoyl]pyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[3-(3,3-difluoroazetidine-1-carbonyl)cyclohexyl]carbamoyl}-6-methoxypyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 cyclohexyl 1-[({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)methyl]cyclopropane-1-carboxylate; 
 6-{5-[(3S)-3-[(4-fluorophenyl)methyl]piperidine-1-carbonyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 4-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)butanoate; 
 tert-butyl (3S)-3-{2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridine-3-amido}pyrrolidine-1-carboxylate; 
 6-[5-({[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-{5-[(cyclohexylmethyl)carbamoyl]-6-methoxypyridin-3-yl}-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl (3S)-3-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)butanoate; 
 cyclopentyl 1-[({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)methyl]cyclopropane-1-carboxylate; 
 tert-butyl (3R)-3-({2-methoxy-5-[3-(methylcarbamoyl)-1H-indazol-6-yl]pyridin-3-yl}formamido)butanoate; 
 6-[5-({3-[cyclopropyl(cyclopropylmethyl)carbamoyl]propyl}carbamoyl)-6-methoxypyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[4-(trifluoromethyl)pyridin-2-yl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 3-({5-[4-fluoro-3-(methylcarbamoyl)-1H-indazol-6-yl]-2-methoxypyridin-3-yl}formamido)-2,2-dimethylpropanoate; 
 6-(5-{[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]carbamoyl}-6-methoxypyridin-3-yl)-4-fluoro-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl (3S)-3-({5-[4-fluoro-3-(methylcarbamoyl)-1H-indazol-6-yl]-2-methoxypyridin-3-yl}formamido)butanoate; 
 4-fluoro-6-[6-methoxy-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 oxan-4-yl 3-[(2-methoxy-5-{3-[(deutero)methylcarbamoyl]-1H-indazol-6-yl}pyridin-3-yl)formamido]-2,2-dimethylpropanoate; 
 tert-butyl 3-[(2-methoxy-5-{3-[(deutero)methylcarbamoyl]-1H-indazol-6-yl}pyridin-3-yl)formamido]-2,2-dimethylpropanoate; 
 tert-butyl 3-[(2-methoxy-5-{3-[(deutero)methylcarbamoyl]-1H-indazol-6-yl}pyridin-3-yl)formamido]propanoate; 
 6-[6-methoxy-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({1-[2-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 N-methyl-6-(6-methyl-5-{[(1S,3R)-3-phenylcyclopentyl]carbamoyl}pyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-methyl-6-[6-methyl-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-methyl-6-[6-methyl-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[5-({[2-(cyclopentyloxy)-5-fluorophenyl]methyl}carbamoyl)-6-methylpyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-2-methyl-5-({1-[2-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(2,2-dimethylcyclopentyl)methyl]carbamoyl}-6-methoxy-2-methylpyridin-3-yl)-N-methyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-2-methyl-5-({[3-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[5-({[2-fluoro-5-(trifluoromethoxy)phenyl]methyl}carbamoyl)-6-methoxy-2-methylpyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[2,6-dimethyl-5-({1-[2-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[2,6-dimethyl-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 6-[2,6-dimethyl-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-N-methyl-1H-indazole-3-carboxamide; 
 tert-butyl 3-[(5-{3-[(cyclopropylmethyl)carbamoyl]-1H-indazol-6-yl}-2-(deutero)methoxypyridin-3-yl)formamido]propanoate; 
 N-(cyclopropylmethyl)-6-[6-(deutero)methoxy-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-(5-{[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(cyclopropylmethyl)-1H-indazole-3-carboxamide; 
 N-(cyclopropylmethyl)-6-[6-(deutero)methoxy-5-({1-[2-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-(1-methanesulfonylpiperidin-4-yl)-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-ethyl-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1R)-1-cyclopropylethyl]-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-(cyclopropylmethyl)-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-[3-(morpholin-4-yl)propyl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-butyl-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-propyl-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-[3-(2-oxopyrrolidin-1-yl)propyl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-(propan-2-yl)-1H-indazole-3-carboxamide; 
 N-(1-acetylpiperidin-4-yl)-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-[5-oxo-1-(propan-2-yl)pyrrolidin-3-yl]-1H-indazole-3-carboxamide; 
 N-(2-hydroxyethyl)-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[4-(diethylamino)cyclohexyl]-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[4-(dimethylamino)cyclohexyl]-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-[1-(2-methoxyphenyl)-5-oxopyrrolidin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-(1-methyl-5-oxopyrrolidin-3-yl)-1H-indazole-3-carboxamide; 
 N-{4-[di(deutero)methylamino]cyclohexyl}-6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[6-methoxy-5-({[2-(trifluoromethoxy)phenyl]methyl}carbamoyl)pyridin-3-yl]-N-[(1r,4r)-4-hydroxycyclohexyl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 6-(5-{[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(3,3-difluorocyclobutyl)-1H-indazole-3-carboxamide; 
 6-(5-{[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-[(1,1,2,2,2-deutero)ethyl]-1H-indazole-3-carboxamide; 
 6-(5-{[(3R,4S)-1-(3,3-difluorocyclobutanecarbonyl)-4-fluoropyrrolidin-3-yl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(2-fluoro-2-methylpropyl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 tert-butyl (3S)-3-({5-[3-(cyclopropylcarbamoyl)-1H-indazol-6-yl]-2-(deutero)methoxypyridin-3-yl}formamido)butanoate; 
 tert-butyl (3R)-3-({5-[3-(cyclopropylcarbamoyl)-1H-indazol-6-yl]-2-(deutero)methoxypyridin-3-yl}formamido)butanoate; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-({1-[3-(trifluoromethoxy)phenyl]ethyl}carbamoyl)pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-(5-{[(3S)-3-(4-chlorophenyl)-3-hydroxypropyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-cyclopropyl-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(3R,4S)-1-(3,3-difluorocyclopentanecarbonyl)-4-fluoropyrrolidin-3-yl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 tert-butyl 3-({5-[3-(cyclopropylcarbamoyl)-1H-indazol-6-yl]-2-(deutero)methoxypyridin-3-yl}formamido)-2,2-dimethylpropanoate; 
 N-cyclopropyl-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethoxy)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[3-(3,3-difluoropyrrolidine-1-carbonyl)cyclohexyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[3-(pyrrolidine-1-carbonyl)cyclohexyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-cyclopropyl-6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 6-[5-({1-[5-fluoro-2-(trifluoromethyl)phenyl]ethyl}carbamoyl)-6-(deutero)methoxypyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethoxy)phenyl]ethyl]carbamoyl}pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}pyridin-3-yl]-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-(deutero)methyl-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[5-({1-[5-fluoro-2-(trifluoromethyl)phenyl]ethyl}carbamoyl)-6-(deutero)methoxypyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-(deutero)methoxy-5-{[(1S)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethoxy)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-(deutero)methoxy-5-{[(1R)-1-[3-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethoxy)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1R)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-[6-(deutero)methoxy-5-{[(1R)-1-[2-(trifluoromethyl)phenyl]ethyl]carbamoyl}pyridin-3-yl]-1H-indazole-3-carboxamide; 
 N-[(1,1,2,2,2-deutero)ethyl]-6-(5-{[(1S)-1-[2-fluoro-5-(trifluoromethyl)phenyl](2,2,2-deutero)ethyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-1H-indazole-3-carboxamide; 
 6-(5-{[(3R)-3-(4-chlorophenyl)-3-hydroxypropyl]carbamoyl}-6-(deutero)methoxypyridin-3-yl)-N-[(1,1,2,2,2-deutero)ethyl]-1H-indazole-3-carboxamide; and 
 tert-butyl (3S)-3-{[5-(3-{[(1,1,2,2,2-deutero)ethyl]carbamoyl}-1H-indazol-6-yl)-2-(deutero)methoxypyridin-3-yl]formamido}butanoate. 
 
     
     
       12. A pharmaceutical composition comprising one or more compounds of  claim 1 , or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
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