US12215132B2ActiveUtilityA1

Methods, compositions and uses thereof for reversing sarcopenia

Assignee: UNIV COLUMBIAPriority: Apr 17, 2020Filed: Oct 18, 2021Granted: Feb 4, 2025
Est. expiryApr 17, 2040(~13.7 yrs left)· nominal 20-yr term from priority
A61K 38/22C07K 2319/00C07K 2319/30A61P 21/06A61K 38/204A61K 38/39A61P 21/00C07K 14/575C07K 14/5412A61K 38/00
61
PatentIndex Score
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Cited by
78
References
4
Claims

Abstract

Exemplary methods, compositions and uses thereof can be provided for preventing, reducing and/or treating loss of muscle function. In particular, e.g., it is possible to administer to a subject a pharmaceutical composition comprising a therapeutically effective amount of an agent that enhances Interleukin-6 (IL) release during exercise, and optionally a pharmaceutically acceptable carrier or excipient.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. A method for reducing loss of muscle function in a subject with sarcopenia, comprising: administering to the subject a pharmaceutical composition which comprises a therapeutically effective amount of Interleukin-6-Bisphosphonate fusion peptide. 
     
     
       2. The method of  claim 1 , wherein the subject is a human. 
     
     
       3. The method of  claim 1 , wherein the Interleukin-6-Bisphosphonate fusion peptide further reduces loss of muscle mass. 
     
     
       4. The method of  claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier or excipient.

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