Human antibodies to human interleukin 18 receptor alpha or beta

Abstract

Provided are antibodies or fragments thereof having binding specificity to anti-IL-18 receptor alpha or beta. Methods of using the antibodies or fragments thereof for treating and diagnosing diseases such as cancer and inflammatory and autoimmune diseases are also provided.

What is claimed is: 
     
       1. An antibody or antigen-binding fragment thereof having binding specificity to a human interleukin-18 receptor beta (IL-18Rβ) protein, wherein the antibody or fragment thereof comprises a light chain variable region (VL) comprising light chain complementarity determining regions CDRL1, CDRL2, and CDRL3 and a heavy chain variable region (VH) comprising heavy chain complementarity determining regions CDRH1, CDRH2, and CDRH3, and wherein the CDRL1, CDRL2, CDRL3, CDRH1, CDRH2 and CDRH3 comprise the amino acid sequences of SEQ ID NO:45, 46, 333, 74, 346 and 117, respectively. 
     
     
       2. An antibody or antigen-binding fragment thereof having binding specificity to a human interleukin-18 receptor beta (IL-18Rβ) protein, wherein the antibody or fragment thereof comprises a light chain variable region (VL) comprising light chain complementarity determining regions CDRL1, CDRL2, and CDRL3 and a heavy chain variable region (VH) comprising heavy chain complementarity determining regions CDRH1, CDRH2, and CDRH3, and wherein the CDRL1, CDRL2, CDRL3, CDRH1, CDRH2 and CDRH3 comprise the amino acid sequences of SEQ ID NO:45, 46, 333, 74, 352 and 117, respectively. 
     
     
       3. The antibody or antigen-binding fragment thereof of  claim 1 , wherein the VL comprises the amino acid sequence of SEQ ID NO:174 and the VH comprises the amino acid sequence of SEQ ID NO:177. 
     
     
       4. The antibody or antigen-binding fragment thereof of  claim 2 , wherein the VL comprises the amino acid sequence of SEQ ID NO: 174 and the VH comprises the amino acid sequence of SEQ ID NO:219. 
     
     
       5. An antibody or antigen-binding fragment thereof having binding specificity to a human interleukin-18 receptor beta (IL-18Rβ) protein, wherein the antibody or fragment thereof comprises a light chain variable region (VL) comprising light chain complementarity determining regions CDRL1, CDRL2, and CDRL3 and a heavy chain variable region (VH) comprising heavy chain complementarity determining regions CDRH1, CDRH2, and CDRH3, and wherein the CDRL1, CDRL2, CDRL3, CDRH1, CDRH2 and CDRH3 comprise the amino acid sequences of SEQ ID NO: 45, 46, 336, 74, 346 and 117, respectively. 
     
     
       6. The antibody or antigen-binding fragment thereof of  claim 5 , wherein the VL comprises the amino acid sequence of SEQ ID NO:216 and the VH comprises the amino acid sequence of SEQ ID NO:177.