Optimal stimulation position combination determination method, server, and computer program using preset guide system

Abstract

Provided are an optimal stimulation position combination determination method using a preset guide system, a server, and a computer program. The optimal stimulation position combination determination method using a preset guide system according to various embodiments of the present invention is executed by a computing device and includes: simulating electric stimulation for a brain of a subject by using a plurality of stimulation position according to a preset guide system; and determining an optimal stimulation position combination for applying the electric stimulation to the preset target point in the brain of the subject by using a simulation result of the electric stimulation.

The invention claimed is: 
     
       1. An optimal stimulation position combination determination method performed by a computing device using a preset guide system to apply electric stimulation to a target point preset to a brain of a subject, comprising:
 simulating the electric stimulation for the brain of the subject by using a plurality of stimulation positions according to the preset guide system; and 
 determining an optimal stimulation position combination for applying the electric stimulation to the preset target point based on a simulation result of the electric stimulation, 
 wherein the simulating the electric stimulation includes:
 filtering stimulation positions corresponding to a preset condition among the plurality of stimulation positions; and 
 simulating the electric stimulation for the brain of the subject by using remaining stimulation positions except for the filtered stimulation positions among the plurality of stimulation positions. 
 
 
     
     
       2. The optimal stimulation position combination determination method according to  claim 1 ,
 wherein the simulating the electric stimulation includes:
 generating a three-dimensional brain map corresponding to the brain of the subject; and 
 simulating the electric stimulation by using the plurality of stimulation positions based on the generated three-dimensional brain map. 
 
 
     
     
       3. The optimal stimulation position combination determination method according to  claim 2 ,
 wherein the generating the three-dimensional brain map includes:
 acquiring an MRI image of the brain of the subject; 
 segmenting the acquired MRI image into a plurality of regions; 
 generating a three-dimensional brain image by using the MRI image segmented into the plurality of regions; and 
 generating the three-dimensional brain map configured with a plurality of meshes based on an attribute of each of the plurality of regions included in the generated three-dimensional brain image. 
 
 
     
     
       4. The optimal stimulation position combination determination method according to  claim 2 ,
 wherein the determining the optimal stimulation position combination includes:
 setting the number of maximum stimulation positions at which the electric stimulation is applied to the preset target point, and 
 correcting the determined optimal stimulation position combination by comparing the number of the optimal stimulation positions included in the determined optimal stimulation position combination with the number of the set maximum stimulation positions. 
 
 
     
     
       5. The optimal stimulation position combination determination method according to  claim 4 ,
 wherein the correcting the determined optimal stimulation position combination includes:
 selecting at least one of the plurality of optimal stimulation positions based on importance of each of the plurality of optimal stimulation positions, in a case where the number of the plurality of optimal stimulation positions included in the determined optimal stimulation position combination exceeds the number of the set maximum stimulation positions, wherein the number of the selected at least one optimal stimulation position is less than or equal to the number of the set maximum stimulation positions; and 
 simulating the electric stimulation by using only the selected at least one optimal stimulation position and correcting the determined optimal stimulation position combination based on a simulation result of the electric stimulation by using only the selected at least one optimal stimulation position. 
 
 
     
     
       6. The optimal stimulation position combination determination method according to  claim 4 , further comprising providing information on the determined optimal stimulation position combination in a case where the number of the plurality of optimal stimulation positions included in the determined optimal stimulation position combination is less than or equal to the number of the set maximum stimulation positions. 
     
     
       7. The optimal stimulation position combination determination method according to  claim 1 ,
 wherein the determining the optimal stimulation position combination includes:
 standardizing a plurality of current values applied to each of the plurality of optimal stimulation positions included in the determined optimal stimulation position combination based on a preset current resolution; 
 primarily correcting each of the plurality of standardized current values so that each of the plurality of standardized current values is a multiple of the preset current resolution; and 
 secondarily correcting at least one current value of the plurality of primarily-corrected current values based on a total sum of the plurality of primarily-corrected current values. 
 
 
     
     
       8. The optimal stimulation position combination determination method according to  claim 7 ,
 wherein the secondarily correcting includes:
 selecting at least one optimal stimulation position among the plurality of optimal stimulation positions based on importance of each of the plurality of optimal stimulation positions in a case where the total sum of the plurality of primarily-corrected current values is not 0 and determining the number of the selected at least one optimal stimulation positions according to a magnitude of the total sum of the plurality of primarily-corrected current values; and 
 secondarily correcting the primarily-corrected current values corresponding to the selected at least one optimal stimulation position so that the total sum of the plurality of primarily-corrected current values is 0. 
 
 
     
     
       9. The optimal stimulation position combination determination method according to  claim 7 ,
 wherein the determining the optimal stimulation position combination further includes:
 providing information on the determined optimal stimulation position combination including a value obtained by multiplying each of the plurality of primarily-corrected current values by the preset current resolution in a case where the total sum of the plurality of primarily-corrected current values is 0. 
 
 
     
     
       10. An optimal stimulation position combination determination server using a preset guide system, comprising:
 a processor; 
 a network interface; 
 a memory; and 
 a computer program loaded on the memory and executed by the processor, 
 wherein the computer program includes:
 an instruction of simulating electric stimulation for a brain of a subject by using a plurality of stimulation positions according to the preset guide system; and 
 an instruction of determining an optimal stimulation position combination for applying the electric stimulation to a preset target point in the brain of the subject, based on a simulation result of the electric stimulation, 
 wherein the instruction of simulating electric stimulation includes:
 an instruction of filtering stimulation positions corresponding to a preset condition among the plurality of stimulation positions; and 
 an instruction of simulating the electric stimulation for the brain of the subject by using remaining stimulation positions except for the filtered stimulation positions among the plurality of stimulation positions. 
 
 
 
     
     
       11. A computer program recorded on a tangible, non-transitory, computer-readable recording medium,
 combined with a computing device, and 
 causing the computing device to execute:
 simulating electric stimulation for a brain of a subject by using a plurality of stimulation position according to a preset guide system; and 
 determining an optimal stimulation position combination for applying the electric stimulation to the preset target point in the brain of the subject by using a simulation result of the electric stimulation, 
 wherein the simulating the electric stimulation includes:
 filtering stimulation positions corresponding to a preset condition among the plurality of stimulation positions; and 
 
 simulating the electric stimulation for the brain of the subject by using remaining stimulation positions except for the filtered stimulation positions among the plurality of stimulation positions.