ICOSL for use as a renal therapeutic

Abstract

Methods treating an aberrant activation of αvβ integrin are provided. The methods include administering a therapeutically effective amount of inducible co-stimulator ligand (ICOSL) polypeptide to a subject in need thereof. Methods of identifying subjects having a kidney injury are also provided.

The invention claimed is: 
     
       1. A method of treating an aberrant activation of αvβ3 integrin comprising:
 administering a therapeutically effective amount of inducible co-stimulator ligand (ICOSL) polypeptide to a subject in need thereof, wherein the therapeutically effective amount of ICOSL polypeptide is used to treat a kidney injury. 
 
     
     
       2. The method according to  claim 1 , wherein the therapeutically effective amount of ICOSL polypeptide is used to treat kidney injury resulting from podocyte diseases or disorders, proteinuria, glomerular diseases, membranous glomerulonephritis, focal segmental glomerulonephritis, minimal change disease, nephrotic syndromes, pre-eclampsia, eclampsia, kidney lesions, collagen vascular diseases, stress, strenuous exercise, benign orthostatic proteinuria, focal segmental glomerulosclerosis (FSGS), IgA nephropathy, IgM nephropathy, membranoproliferative glomerulonephritis, membranous nephropathy, sarcoidosis, Alport's syndrome, diabetes mellitus, kidney damage due to drugs, Fabry's disease, infections, aminoaciduria, Fanconi syndrome, hypertensive nephrosclerosis, interstitial nephritis, Sickle cell disease, hemoglobinuria, multiple myeloma, myoglobinuria, diabetic nephropathy (DN), lupus nephritis, Wegener's Granulomatosis or Glycogen Storage Disease Type 1. 
     
     
       3. The method according to  claim 1 , wherein the therapeutically effective amount of ICOSL polypeptide is used to treat FSGS. 
     
     
       4. The method according to  claim 1 , wherein the therapeutically effective amount of ICOSL polypeptide is used to treat kidney injury resulting from diabetic neuropathy. 
     
     
       5. The method according to  claim 1 , wherein the ICOSL polypeptide comprises SEQ ID NO: 1 or an active fragment thereof. 
     
     
       6. The method according to  claim 1 , wherein the ICOSL polypeptide comprises amino acids 1-258 of SEQ ID NO: 1.