US12331333B2ActiveUtilityA1

Enhancers of neurolysin activity

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Assignee: UNIV TEXAS TECH SYSTEMPriority: Aug 31, 2018Filed: Feb 26, 2021Granted: Jun 17, 2025
Est. expiryAug 31, 2038(~12.1 yrs left)· nominal 20-yr term from priority
C12Y 304/24016C07K 5/06147C12N 9/6489A61K 38/00C12N 9/6416C12P 21/06
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PatentIndex Score
0
Cited by
84
References
5
Claims

Abstract

The present invention includes a composition and method of allosterically potentiating the activity of neurolysin comprising contacting the neurolysin with an amount of a histidine-containing dipeptide that is an allosteric that increases the activity of neurolysin.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
       1. An allosteric activator of neurolysin selected from at least one of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       salts, or enantiomers thereof. 
     
     
       2. The activator of  claim 1 , wherein the inhibitor is adapted for oral, intraperitoneal, intradermal, subcutaneous, intravenous, enteral, parental, or pulmonary administration. 
     
     
       3. The activator of  claim 1 , wherein the inhibitor is combined with one or more excipients, buffers, fillers, or detergents. 
     
     
       4. The activator of  claim 1 , wherein the inhibitor is adapted for at least one of immediate release, delayed release, or prolonged release. 
     
     
       5. The activator of  claim 1 , wherein the activator comprises a single enantiomer.

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