Disubstituted alkyne derivatives

Abstract

The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

The invention claimed is: 
     
       1. A compound of formula (I) 
       
         
           
           
               
               
           
         
         wherein 
         W denotes CR W1  or N; 
         R W1  is H, halogen, R a  or —OR a ; 
         R 1  is —OH, —OR a , —NH 2 , —NHR a , —NR a R b , —N(H)OH, —N(H)O—R a , —N(H)CN, —N(H)—C(═O)—R a  or —N(H)—SO 2 —R a ; or R 1  together with R 2  forms a divalent —O—CH 2 — or —N—CH 2 — radical; 
         R 2  is H, halogen, —CN, R a , —OH, —OR a , NH 2 , —NH—R a  or —NR a R b ; 
         R 3  is H, halogen, R a , —OH, —OR a , NH 2 , —NH—R a , —NR a R b , —NO 2  or unsubstituted or substituted phenyl;
 or 
 
         R 2  and R 3  form together with the carbon atoms to which they are attached to an unsubstituted or substituted six-membered aromatic ring; or form together a divalent —NH—CH 2 —CH 2 —NH— radical; 
         R 4  is H or R a ; 
         R 5  is H or halogen; 
         R 6  is H, halogen, R a , —OR a , NH 2 , —NHR a , —NR a R b , —NO 2  or Ar A ; 
         R 7  is H, halogen, R a , —OR a , NH 2 , —NHR a , —NR a R b , —N(H)—C(═O)—R a  or —C(═O)—NHR a ; 
         R 8  is H, halogen or R a ; 
         n is an integer selected from 0 and 1; 
         L 1  is a divalent —NH—, —N(R a )— or —CH 2 — radical; and 
         L 2  is a divalent —SO 2 — radical; and 
         L 3  is a divalent —CH═CH— radical;
 or 
 
         L 1  is a divalent —N(CHO)—, —N(C(═O)—R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )— radical; and 
         L 2  is a divalent —CH 2 — radical; and 
         L 3  is a divalent —CH 2 — radical;
 or 
 
         L 1  is a divalent —CH 2 — radical; 
         L 2  is a divalent —N(CHO)—, —N(C(═O)—R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )— radical; and 
         L 3  is a single bond;
 or 
 
         L 1  is a divalent —N=radical; 
         L 2  is a divalent ═S(═O)(R a )— radical; and 
         L 3  is a single bond; 
         A is a ring selected from the group consisting of Ar A , Hetar A , Cyc A  and Hetcyc A ; 
         Ar A  is a mono-, bi- or tricyclic aryl with 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 , R A5 , R A6  and/or R A7  which may be the same or different, with the proviso that Ar A  is not 4-methylphenyl; 
         Hetar A  is a mono-, bi- or tricyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 R A5 , R A6  and/or R A7  which may be the same or different; 
         Cyc A  is a saturated or partially unsaturated, mono-, bi- or tricyclic carbocycle with 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 ring carbon atoms, wherein that carbocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
         Hetcyc A  is a saturated or partially unsaturated, mono-, bi- or tricyclic heterocycle with 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heterocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
         R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  are independently from each other H, halogen, R a , —OR a , —NH 2 , —NHR a , —NR a R b , —N(H)—C(═O)—R a , Ar B , —O—Ar B , Hetar B , Cyc B  or Hetcyc B ;
 and/or 
 
         two adjacent R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  may form together a divalent —C 1-3 -alkylene-O— or —O—C 1-3 -alkylene-O— radical which C 1-3 -alkylene may be unsubstituted or mono- or disubstituted with R a  or halogen; or may form together with the ring atoms to which they are attached to a Cyc C ; 
         R A8 , R A9 , R A10 , R 11  are independently from each other H or R a ; or a pair of R A8 , R A9 , R A10  and/or R A11  form a ═O radical; 
         Ar B  is a phenyl ring, wherein that phenyl ring may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
         Hetar B  is a monocyclic heteroaryl with 5, 6, 7 ring atoms wherein 1, 2, 3, 4 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroryl may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
         Cyc B  is a mono- or bicyclic saturated or partially unsaturated carbocycle with 5, 6, 7, 8, 9, 10 ring carbon atoms wherein that carbocycle may be unsubstituted or mono-, di- or trisubstituted with R B4 , R B5  and/or R B6  which may be the same or different; 
         Hetcyc B  is a saturated or partially unsaturated monocyclic heterocycle with 3, 4, 5, 6, 7 ring atoms wherein 1, 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heterocycle may be unsubstituted or mono-, di- or trisubstituted with R B4 , R B5  and/or R B6  which may be the same or different; 
         Cyc C  is a mono- or bicyclic saturated or partially unsaturated carbocycle with 5, 6, 7, 8, 9, 10 ring carbon atoms wherein that carbocycle is fused to Ar A  or Hetar A  via 2 adjacent ring atoms of said Ar A  or Hetar A  and wherein that carbocycle may be unsubstituted or substituted with R C1 , R C2 , R C3 , R C4 , R C5 , R C6  which may be the same or different; 
         R B1 , R B2  and/or R B3  are independently from each other H, halogen, R a , —OR a  or —SR a ; 
         R B4 , R B5 , R B6 , R C1 , R C2 , R C3 , R C4 , R C5 , R C6  are independently from each other H or R a ; 
         R a , R b  are independently from each other unsubstituted or substituted, straight-chain or branched C 1-6 -aliphatic or may form together with the nitrogen atom to which they are attached to an unsubstituted or substituted saturated, partially unsaturated or aromatic heterocycle with 4, 5, 6, 7 ring atoms wherein 1, 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms; 
         or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing; 
         with the proviso that 
         (a) 4-{2-[5-chloro-2-(4-chlorobenzenesulfonamido)phenyl]ethynyl}-benzoic acid; 
         (b) methyl 4-{2-[5-chloro-2-(4-chlorobenzenesulfonamido)phenyl]-ethynyl}benzoate; and 
         (c) methyl 4-{2-[2-(N-benzyl-2,2,2-trifluoroacetamido)phenyl]ethynyl}-benzoate 
         are excluded. 
       
     
     
       2. A compound of formula (I) 
       
         
           
           
               
               
           
         
         wherein 
         W denotes CR W1  or N; 
         R W1  is H, halogen, R a  or —OR a ; 
         R 1  is —OH, —OR a , —NH 2 , —NHR a , —NR a R b , —N(H)OH, —N(H)O—R a , —N(H)CN, —N(H)—C(═O)—R a  or —N(H)—SO 2 —R a ; or R 1  together with R 2  forms a divalent —O—CH 2 — or —N—CH 2 — radical; 
         R 2  is H, halogen, —CN, R a , —OH, —OR a , NH 2 , —NH—R a  or —NR a R b ; 
         R 3  is H, halogen, R a , —OH, —OR a , NH 2 , —NH—R a , —NR a R b , —NO 2  or unsubstituted or substituted phenyl;
 or 
 
         R 2  and R 3  form together with the carbon atoms to which they are attached to an unsubstituted or substituted six-membered aromatic ring; or form together a divalent —NH—CH 2 —CH 2 —NH— radical; 
         R 4  is H or R a ; 
         R 5  is H or halogen; 
         R 6  is H, halogen, R a , —OR a , NH 2 , —NHR a , —NR a R b , —NO 2  or Ar A ; 
         R 7  is H, halogen, R a , —OR a , NH 2 , —NHR a , —NR a R b , —N(H)—C(═O)—R a  or —C(═O)—NHR a ; 
         R 8  is H, halogen or R a ; 
         n is an integer selected from 0 and 1; 
         L 1  is a divalent —NH—, —N(R a )— or —CH 2 — radical; and 
         L 2  is a divalent —SO 2 — radical; and 
         L 3  is a divalent —CH═CH— radical;
 or 
 
         L 1  is a divalent —N(CHO)—, —N(C(═O)—R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )— radical; and 
         L 2  is a divalent —CH 2 — radical; and 
         L 3  is a divalent —CH 2 — radical;
 or 
 
         L 1  is a divalent —CH 2 — radical; 
         L 2  is a divalent —N(CHO)—, —N(C(═O)—R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )— radical; and 
         L 3  is a single bond; 
         A is a ring selected from the group consisting of Ar A , Hetar A , Cyc A  and Hetcyc A ; 
         Ar A  is a mono-, bi- or tricyclic aryl with 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 ring carbon atoms, wherein that aryl may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 , R A5 , R A6  and/or R A7  which may be the same or different, with the proviso that Ar A  is not 4-methylphenyl; 
         Hetar A  is a mono-, bi- or tricyclic heteroaryl with 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroaryl may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 R A5 , R A6  and/or R A7  which may be the same or different; 
         Cyc A  is a saturated or partially unsaturated, mono-, bi- or tricyclic carbocycle with 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 ring carbon atoms, wherein that carbocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
         Hetcyc A  is a saturated or partially unsaturated, mono-, bi- or tricyclic heterocycle with 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 ring atoms wherein 1, 2, 3, 4, 5 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heterocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
         R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  are independently from each other H, halogen, R a , —OR a , —NH 2 , —NHR a , —NR a R b , —N(H)—C(═O)—R a , Ar B , —O—Ar B , Hetar B , Cyc B  or Hetcyc B ;
 and/or 
 
         two adjacent R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  may form together a divalent —C 1-3 -alkylene-O— or —O—C 1-3 -alkylene-O— radical which C 1-3 -alkylene may be unsubstituted or mono- or disubstituted with R a  or halogen; or may form together with the ring atoms to which they are attached to a Cyc C ; 
         R A8 , R A9 , R A10 , R A11  are independently from each other H or R a ; or a pair of R A8 , R A9 , R A10  and/or R A11  form a ═O radical; 
         Ar B  is a phenyl ring, wherein that phenyl ring may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
         Hetar B  is a monocyclic heteroaryl with 5, 6, 7 ring atoms wherein 1, 2, 3, 4 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroryl may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
         Cyc B  is a mono- or bicyclic saturated or partially unsaturated carbocycle with 5, 6, 7, 8, 9, 10 ring carbon atoms wherein that carbocycle may be unsubstituted or mono-, di- or trisubstituted with R B4 , R B5  and/or R B6  which may be the same or different; 
         Hetcyc B  is a saturated or partially unsaturated monocyclic heterocycle with 3, 4, 5, 6, 7 ring atoms wherein 1, 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heterocycle may be unsubstituted or mono-, di- or trisubstituted with R B4 , R B5  and/or R B6  which may be the same or different; 
         Cyc C  is a mono- or bicyclic saturated or partially unsaturated carbocycle with 5, 6, 7, 8, 9, 10 ring carbon atoms wherein that carbocycle is fused to Ar A  or Hetar A  via 2 adjacent ring atoms of said Ar A  or Hetar A  and wherein that carbocycle may be unsubstituted or substituted with R C1 , R C2 , R C3 , R C4 , R C5 , R C6  which may be the same or different; 
         R B1 , R B2  and/or R B3  are independently from each other H, halogen, R a , —OR a  or —SR a    
         R B4 , R B5 , R B6 , R C1 , R C2 , R C3 , R C4 , R C5 , R C6  are independently from each other H or R a ; 
         R a , R b  are independently from each other unsubstituted or substituted, straight-chain or branched C 1-6 -aliphatic or may form together with the nitrogen atom to which they are attached to an unsubstituted or substituted saturated, partially unsaturated or aromatic heterocycle with 4, 5, 6, 7 ring atoms wherein 1, 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms; 
         or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing; 
         with the proviso that 
         (a) 4-{2-[5-chloro-2-(4-chlorobenzenesulfonamido)phenyl]ethynyl}-benzoic acid; 
         (b) methyl 4-{2-[5-chloro-2-(4-chlorobenzenesulfonamido)phenyl]-ethynyl}benzoate; and 
         (c) methyl 4-{2-[2-(N-benzyl-2,2,2-trifluoroacetamido)phenyl]ethynyl}-benzoate 
         are excluded. 
       
     
     
       3. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 R 5  is H; 
 R 6  is H, halogen, R a , —OR a , —NH 2 , —NHR a — or NR a R b ; 
 R 7  is H, halogen, R a  or —OR a ; and 
 R 8  is H or halogen. 
 
     
     
       4. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 W denotes CR W1  or N; 
 R W1  is H, R a  or —OR a ; 
 R 1  is —OH, OR a , NHR a  or NH—OH; 
 R 2  is H, halogen, R a , —OR a , —NH 2 , —NHR a  or —NR a R b ; 
 R 3  is H, halogen, R a , —OR a , —NH 2 , —NHR a , —NR a R b , —NO 2  or phenyl; 
 or 
 R 2  and R 3  form together with the carbon atoms to which they are attached to a benzo ring; and 
 R 4  is H. 
 
     
     
       5. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 W is N; and 
 R 2  is H, halogen, R a , —OR a , —NH 2 , —NHR a  or —NR a R b ; 
 R 3  is H, halogen, R a , —OR a , —NH 2 , —NHR a , —NR a R b , —NO 2  or phenyl; 
 thereby forming a compound of formula (I-a) 
 
       
         
           
           
               
               
           
         
         or 
         R 2  and R 3  form together with the carbon atoms to which they are attached to a benzo ring thereby forming a compound of formula (I-b) 
       
       
         
           
           
               
               
           
         
         wherein R 1 , R 4 , R 5 , R 6 , R 7 , R 8 , n, L 1 , L 2 , L 3  and A are as defined in  claim 1 . 
       
     
     
       6. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 n is 0; 
 L 1  is a divalent —NH— radical; and 
 L 2  is a divalent —SO 2 — radical;
 or 
 
 L 1  is a divalent —N(CHO)— radical; and 
 L 2  is a divalent —CH 2 — radical. 
 
     
     
       7. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 A is a ring selected from the group consisting of Ar A , Hetar A , Hetcyc A  and Cyc A ; 
 Ar A  is a phenyl or naphthyl radical which radical may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 , R A5 , R A6  and/or R A7  which may be the same or different, with the proviso that Ar A  is not 4-methylphenyl; 
 Hetar A  is a monocyclic heteroaryl with 5 or 6 ring atoms, a bicyclic heteroaryl with 9 or 10 ring atoms or a tricyclic heteroaryl with 13 ring atoms wherein 1, 2 or 3 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroryl may be unsubstituted or substituted with substituents R A1 , R A2 , R A3 , R A4 , R A5 , R A6  and/or R A7  which may be the same or different; 
 Cyc A  is a saturated or partially unsaturated, monocyclic carbocycle with 5, 6 or 7 ring carbon atoms or a bicyclic carbocycle with 9 or 10 ring carbon atoms, wherein that carbocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
 Hetcyc A  is a saturated or partially unsaturated, monocyclic heterocycle with 5 or 6 ring atoms or a saturated or partially unsaturated, bicyclic heterocycle with 9 or 10 ring atoms wherein 1 or 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heterocycle may be unsubstituted or substituted with R A8 , R A9 , R A10  and/or R A11  which may be the same or different; 
 R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  are independently from each other H, halogen, R a , —OR a , —NH 2 , —NHR a , —NR a R b , —N(H)—C(═O)—R a , Ar B , Hetar B  or Cyc B ;
 and/or 
 
 two adjacent R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  may form together a divalent —C 1-3 -alkylen-O— or —O—C 1-3 -alkylene-O— radical; or may form together with the ring atoms to which they are attached to a Cyc C ; 
 R A8 , R A9 , R A10  and/or R A11  are independently from each other H or R a ; or 
 a pair of R A8 , R A9 , R A10  and R A11  form a ═O radical; 
 Ar B  is a phenyl ring, wherein that phenyl ring may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
 Hetar B  is a monocyclic heteroaryl with 5 or 6 ring atoms wherein 1 or 2 of said ring atoms is/are a hetero atom(s) selected from N, O and/or S and the remaining are carbon atoms, wherein that heteroryl may be unsubstituted or substituted with substituents R B1 , R B2  and/or R B3  which may be the same or different; 
 Cyc B  is a monocyclic 6-membered or bicyclic 9-membered saturated or partially unsaturated carbocycle wherein that carbocycle is unsubstituted; 
 Cyc C  is a monocyclic 6-membered or bicyclic 9-membered carbocycle wherein that carbocycle is fused to a Ar A  or Hetar A  via 2 adjacent ring atoms of said Ar A  or Hetar A ; 
 R B1 , R B2  and/or R B3  are independently from each other H, R a , —OR a  or —SR a ; and 
 R a  is unsubstituted or substituted, straight-chain or branched C 1-6 -aliphatic. 
 
     
     
       8. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 A is a ring selected from the group consisting of Ar A , Hetar A , Hetcyc A  and Cyc A ; 
 Ar A  is selected from the group consisting of phenyl or naphthyl each of which is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently from each other selected from the group consisting of R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , and R A7 , with the proviso that Ar A  is not 4-methylphenyl; 5,6,7,8-tetrahydronaphthyl (tetralinyl) or 9H-fluorenyl each of which is unsubstituted or substituted with 1, 2 or 3 substituents on the aromatic part of said tetrahydronaphthyl or fluorenyl radical independently from each other selected from the group consisting of R A1 , R A2 , R A3 , R A4 , R A5 , R A6  and R A7  and/or 1, 2 or 3 substituents on the non-aromatic part of said tetrahydronaphthyl or fluorenyl radical independently from each other selected from the group consisting of R C1 , R C2 , R C3 , R C4 , R C5 , and R C6 ; 
 Hetar A  is selected from the group consisting of pyrrolyl, furanyl, thienyl, pyrazolyl, imidazolyl, pyridinyl, indolyl, benzofuranyl, benzothienyl, benzothiazolyl, benzooxadiazolyl, benzofuranzanyl, benzothiadiazolyl, imidazopyridinyl, quinolinyl, isoquinolinyl, quinoxalinyl, dibenzofuranyl, 9H-carbazolyl and azatricyclotridecapentaendionyl each of which is unsubstituted or substituted with 1, 2 or 3 substituents independently from each other selected from the group consisting of R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , and R A7 , 
 Cyc A  is selected from the group consisting of cyclohexenyl, 1,4-dihydronaphth-1-yl 1,4-dihydronaphth-2-yl, 2,3-dihydronaphth-1-yl, 2,3-dihydronaphth-2-yl, 2,3-dihydronaphth-3-yl, 2,3-dihydronaphth-4-yl, indan-1-yl, and indan-2-yl each of which is unsubstituted or substituted with 1, 2 or 3 substituents independently from each other selected from the group consisting of R A8 , R A9 , R A10  and R A11 , 
 Hetcyc A  is selected from the group consisting of decahydroquinolinyl, decahydroisoquinolinyl, octahydro-1H-indolyl, 2,3-dihydro-1H-indolyl, 1H,2H,3H-pyrrolopyridinyl, 1,2,3,4-tetrahydroisoquinolinyl, and 1,2,3,4-tetrahydronaphthridinyl, each of which is unsubstituted or substituted with 1, 2 or 3 substituents independently from each other selected from the group consisting of R A8 , R A9 , R A10  and R A11 ; 
 R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  are independently from each other H, halogen, R a , —OR a , —NR a R b , —N(H)—C(═O)—R a , Ar B , —O—Ar B , Hetar B  or Cyc B ;
 and/or 
 
 two adjacent R A1 , R A2 , R A3 , R A4 , R A5 , R A6 , R A7  may form together a divalent —C 1-3 -alkylene-O— or —O—C 1-3 -alkylene-O— radical which C 1 -3-alkylene may be unsubstituted or mono- or disubstituted with R a    
 R A8 , R A9 , R A10 , R A11  are independently from each other H or R a ; or a pair of R A8 , R A9 , R A10  and/or R A11  form a ═O radical; 
 Ar B  is phenyl which is unsubstituted or substituted with 1, 2 or 3 substituents independently from each other selected from the group consisting of R B1 , R B2  and R B3 ;
 Hetar B  is pyrrolyl, furanyl, thienyl, pyrazolyl, imidazolyl, pyridinyl or pyrimidinyl, each of which is unsubstituted or substituted with 1, 2 or 3 substituents independently from each other selected from the group consisting of R B1 , R B2  and R B3 ; 
 Cyc B  is cyclohexenyl; 
 
 R B1 , R B2  and/or R B3  are independently from each other H, R a , —OR a  or —SR a ; 
 R a  is unsubstituted or substituted, straight-chain or branched C 1-6 -aliphatic; and 
 halogen is F, Cl or Br. 
 
     
     
       9. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein
 W denotes CR W1  or N; 
 R W1  is H or —OCH 3 ; 
 R 1  is —OH, —OC 1-4 -alkyl, —OCH 2 CH(OH)—CH 2 OH, —O(CH 2 ) 2 O(CH 2 ) 2 OH, —O(CH 2 ) 2 OCH 3 , 
 
       
         
           
           
               
               
           
         
          —OCH 2 -phenyl or —NHCH(CH 3 ) 2 ; 
         R 2  is H, F, Cl, CH 3 , C 2 H 5 , —CH 2 OH, —OCH 3 , —OC 2 H 5 , —NH 2 , —NHCH 3  or —NHC 2 H 5 ; 
         R 3  is H, F, Cl, CH 3 , —C(═CH 2 )CH 3 , —OCH 3 , —OC 2 H 5 , phenyl, —N(CH 3 ) 2  or —NO 2 ;
 or 
 
         R 2  and R 3  form together with the carbon atoms to which they are attached to a benzo ring; 
         R 4  is H; 
         R 5  is H; 
         R 6  is H, F, Cl, Br, I, —CH 3 , —C 2 H 5 , —CH(CH 3 ) 2 , —OCH 3  or —N(CH 3 ) 2 ; 
         R 7  is H, F, Cl, Br, CH 3 , CF 3  or —OCH 3 ; 
         R 8  is H or F; 
         n is 0; 
         L 1  is a divalent —NH— or —N(CH 3 )— radical; and 
         L 2  is a divalent —SO 2 — radical;
 or 
 
         L 1  is a divalent —N(CHO)— radical; and 
         L 2  is a divalent —CH 2 — radical; and 
         A is a ring selected from the group consisting of Ar A , Hetar A , Cyc A  and Hetcyc A ; 
         Ar A  is selected from the group consisting of 4-methoxyphenyl, 4-methoxy-2-methylphenyl, 4-methoxy-3-methylphenyl, 2,3-dimethyl-4-methoxyphenyl, 2,3,6-trimethyl-4-methoxyphenyl, 2,3-dichloro-4-methoxyphenyl, 3-acetamido-4-ethoxyphenyl, 4-(cyclohex-1-en-1-yl)phenyl, 1,1′-biphenyl-2-yl, 1,1′-biphenyl-3-yl, 1,1′-biphenyl-4-yl, 2′-methyl-1,1′-biphenyl-4-yl, 2-methoxy-1,1′-biphenyl-4-yl, 3-methoxy-1,1′-biphen-4-yl, 2′-methoxy-1,1′-biphenyl-2-yl, 2′-methoxy-1,1′-biphenyl-3-yl, 2′-methoxy-1,1′-biphenyl-4-yl, 3-phenoxyphenyl, 4-(1H-pyrazol-1-yl)phenyl, 3-(pyridin-2-yl)phenyl, 3-(pyridin-3-yl)phenyl, 3-(6-methoxypyridin-2-yl)phenyl, 3-(2,6-dimethoxypyridin-3-yl)phenyl, naphth-1-yl, naphth-2-yl, 4-bromonaphth-1-yl, 4-methylnaphth-1-yl, 1-methylnaphth-2-yl, 4-methoxynaphth-1-yl, 4-methoxynaphth-2-yl, 4-ethoxynaphth-1-yl, 4-propan-2-yloxynaphth-1-yl, 5-chloronaphth-1-yl, 6-chloronaphth-2-yl, 5,6,7,8-tetrahydronaphth-2-yl, 4-methoxy-5,6,7,8-tetrahydronaphth-1-yl, and 9H-fluoren-2-yl; 
         Hetar A  is selected from the group consisting of 5-bromo-6-methoxypyridin-3-yl, 6-phenylpyridin-3-yl, 1-methylindol-4-yl, 1-benzofuran-2-yl, 1-benzothiophen-3-yl, 5-chloro-1-benzothiophen-2-yl, 5-chloro-3-methyl-1-benzothiophen-2-yl, 1,3-benzothiazol-4-yl, quinolin-2-yl, quinolin-8-yl, 2-methylquinolin-8-yl, 3-methylquinolin-8-yl, 4-methylquinolin-8-yl, 6-methylquinolin-8-yl, 7-methylquinolin-8-yl, 4,7-dimethylquinolin-8-yl, 5,7-dimethylquinolin-8-yl, 5,6,7-trimethylquinolin-8-yl, 5-ethylquinolin-8-yl, 5-(n-propyl-)quinolin-8-yl, 2-methoxyquinolin-8-yl, 4-methoxyquinolin-8-yl, 5-methoxyquinolin-8-yl, 5-trifluormethoxyquinolin-8-yl, 5-ethoxyquinolin-8-yl, 7-ethoxyquinolin-8-yl, 5-(propan-2-yloxy)quinolin-8-yl, 7-(propan-2-yloxy)quinolin-8-yl, 4-prop-2-yn-1-oxyquinolin-8-yl, 3-chloroquinolin-8-yl, 4-chloroquinolin-8-yl, 6-fluorooquinolin-8-yl, 2,4-dichloroquinolin-8-yl, 3,4-dichloroquinolin-8-yl, 4,7-dichloroquinolin-8-yl, 5,7-dichloroquinolin-8-yl, 7-bromo-2-chloroquinolin-8-yl, 4-chloro-7-fluoroquinolin-8-yl, 7-bromo-4-chloroquinolin-8-yl, 6-chloro-2-methylquinolin-8-yl, 4-dimethyl-aminoquinolin-8-yl, 9H-carbazol-2-yl, 9-methyl-9H-carbazol-3-yl, 9-methyl-9H-carbazol-4-yl, dibenzofuran-2-yl, and dibenzofuran-3-yl; 
         Cyc A  is 3,4-dihydronaphth-2-yl; and 
         Hetcyc A  is selected from the group consisting of 2,3-dihydro-1H-indol-1-yl, octahydro-1H-indol-1-yl, decahydroquinolin-1-yl, 4a,8a-trans-decahydroquinolin-1-yl, 4aR,8aS-decahydroquinolin-1-yl, decahydroquinolin-2-yl, 4-methyldecahydroquinolin-1-yl, and 1,2,3,4-tetrahydro-1,8-naphthyridin-1-yl. 
       
     
     
       10. The Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein the compound is selected from the group consisting of
 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)-4-methoxypyridine-2-carboxylic acid; 
 3-(methylamino)-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-iodo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methoxy-5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4a,8a-trans)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]-4-methoxypyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-isoquinoline-1-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-[2-(5-Methoxy-quinoline-8-sulfonylamino)-5-methyl-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-Methoxy-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenyl-ethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Methyl-2-(7-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-(ethylamino)-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2,3-dihydroxypropyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylate; 
 5-{2-[5-ethyl-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-methyl-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methyl-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{8-oxatricyclo[7.4.0.0 2 ,7]trideca-1(9),2(7),3,5,10,12-hexaene-6-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylate; 
 methyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-(2-{2-[(decahydroquinoline-1-sulfonyl)amino]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 methyl 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylate; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylic acid; 
 4-chloro-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 4-chloro-5-{2-[2-(7-methylquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 4-chloro-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-(prop-1-en-2-yl)pyridine-2-carboxylic acid; 
 4-chloro-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-[2-(2-{[(4aR,8aS)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 ethyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 propyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 propan-2-yl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylate; 
 butyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-methoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 benzyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-ethoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-ethoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[4,5-dichloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}-ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[4-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}-ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{[N-(naphthalen-2-yl)formamido]methyl}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[4,5-dichloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[7-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({3-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 4-methoxy-5-[2-(2-{[(4-methyl-decahydroquinolin-1-yl)sulfonyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4a,8a-trans)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-phenylpyridine-2-carboxylic acid; 
 5-{2-[2-(9-methyl-9H-carbazole-3-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4-methyl-decahydroquinolin-1-yl)sulfonyl]amino}phenyl)-ethynyl]pyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-isoquinoline-1-carboxylic acid; 
 4-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-isoquinoline-1-carboxylic acid; 
 4-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-isoquinoline-1-carboxylic acid; 
 2-(methylamino)-4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}benzoic acid; 
 4-methoxy-5-{2-[2-(4-methoxy-2, 3-dimethylbenzenesulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid methyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)-5-nitrophenyl]ethynyl}-pyridine-2-carboxylate; 
 5-{2-[5-methoxy-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(4-Chloro-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[2-(4-ethoxynaphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-(2-{2-[4-(propan-2-yloxy)naphthalene-1-sulfonamido]phenyl}ethynyl)-pyridine-2-carboxylic acid; 
 5-{2-[2-(3,4-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4,7-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5,6,7-trimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5,7-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(4,7-dimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-bromo-2-chloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-bromo-4-chloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4-chloro-7-fluoroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 4-methoxy-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Methyl-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(5-Trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Chloro-2-(4-methoxy-2,3-dimethyl-benzenesulfonylamino)-phenyl-ethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Chloro-2-(4-methoxy-benzenesulfonylamino)-phenylethynyl]-4-methoxy-pyridine-2-carboxylic acid; 
 5-[5-Methoxy-2-(5-methoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}isoquinoline-1-carboxylic acid; 
 4-[5-Chloro-2-(4-methoxy-2,3-dimethyl-benzenesulfonylamino)-phenyl-ethynyl]-isoquinoline-1-carboxylic acid; 
 7-methyl-N-[2-(2-{7-oxo-5H,7H-furo[3,4-b]pyridin-3-yl}ethynyl)phenyl]-quinoline-8-sulfonamide; 
 3-amino-5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 2,3-dihydroxypropyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)-5-methylphenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-propylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(N-methylnaphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-(2-{2-[(naphthalene-2-sulfonyl)methyl]phenyl}ethynyl)benzoic acid; 
 4-{2-[2-(5,6,7,8-tetrahydronaphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-methyl-4-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(4-methoxy-5,6,7,8-tetrahydronaphthalene-1-sulfonamido)-phenyl]ethynyl}benzoic acid; 
 2-fluoro-4-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[5-fluoro-2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(naphthalene-2-sulfonamido)-4-(trifluoromethyl)phenyl]ethynyl}-benzoic acid; 
 4-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}-2-methylbenzoic acid; 
 4-{2-[4-methoxy-2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(5-chloro-3-methyl-1-benzothiophene-2-sulfonamido)phenyl]-ethynyl}benzoic acid; 
 4-{2-[2-(2,3-dichloro-4-methoxybenzenesulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[5-fluoro-2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}-benzoic acid; 
 4-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-chloro-4-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 3-fluoro-4-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[3-fluoro-2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-methoxy-4-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[5-fluoro-2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 4-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[6-methyl-2-(naphthalene-2-sulfonamido)pyridin-3-yl]ethynyl}benzoic acid; 
 5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(6-chloronaphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2-fluoro-4-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}-benzoic acid; 
 4-{2-[4-methyl-2-(naphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(4-methoxy-2-methylbenzenesulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(5-bromo-6-methoxypyridine-3-sulfonamido)phenyl]ethynyl}benzoic acid; 
 3-methyl-5-{2-[2-(naphthalene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(4-methoxy-3-methylbenzenesulfonamido)phenyl]ethynyl}benzoic acid; 
 2-ethoxy-4-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]-ethynyl}benzoic acid; 
 3-methyl-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methyl-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2-methoxy-4-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[2-(4-methoxynaphthalene-1-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 2-methoxy-4-{2-[2-(4-methoxy-2-methylbenzenesulfonamido)-phenyl]ethynyl}benzoic acid; 
 4-{2-[5-fluoro-2-(naphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-fluoro-4-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(1-benzofuran-2-sulfonamido)phenyl]ethynyl}benzoic acid 3-methyl-5-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(4-methylnaphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-{2-[2-(3,4-dihydronaphthalene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-methyl-4-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[2-(3,4-dihydronaphthalene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(1-benzothiophene-3-sulfonamido)phenyl]ethynyl}benzoic acid 
 4-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}benzoic acid 
 4-methyl-5-{2-[2-(naphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[1,1′-biphenyl]-3-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(1-methylnaphthalene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[(decahydroisoquinoline-2-sulfonyl)amino]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[2-(1-benzothiophene-3-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(1,3-benzothiazole-4-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{2′-methoxy-[1,1′-biphenyl]-3-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-[2-(2-{N-[(naphthalen-2-yl)methyl]formamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-[2-(2-{N-[(naphthalen-2-yl)methyl]acetamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(2-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylic acid; 
 5-[2-(2-{N-[(quinolin-2-yl)methyl]acetamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(9H-carbazole-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[3-(2,6-dimethoxypyridin-3-yl)benzenesulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-(2-{2-[(2,3-dihydro-1H-indole-1-sulfonyl)amino]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-(2-{2-[3-(6-methoxypyridin-2-yl)benzenesulfonamido]phenyl}ethynyl)-pyridine-2-carboxylic acid; 
 5-{2-[2-(4-bromonaphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 5-(2-{2-[3-(pyridin-3-yl)benzenesulfonamido]phenyl}ethynyl)pyridine-2-carboxylate; 
 methyl 5-(2-{2-[4-(1H-pyrazol-1-yl)benzenesulfonamido]phenyl}ethynyl)-pyridine-2-carboxylate; 
 methyl 5-[2-(2-{[1,1′-biphenyl]-2-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylate; 
 methyl 4-methyl-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}-5-fluorophenyl)ethynyl]-4-methyl-pyridine-2-carboxylic acid; 
 methyl 5-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}-5-fluorophenyl)ethynyl]-4-methylpyridine-2-carboxylate; 
 methyl 5-[2-(2-{carbamoyl[(naphthalen-2-yl)methyl]amino}phenyl)-ethynyl]pyridine-2-carboxylate; 
 5-[2-(2-{[1,1′-biphenyl]-2-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-(2-{2-[4-(1H-pyrazol-1-yl)benzenesulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{carbamoyl[(naphthalen-2-yl)methyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(9-methyl-9H-carbazole-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[(1,2,3,4-tetrahydro-1,8-naphthyridine-1-carbonyl)amino]phenyl}-ethynyl)pyridine-2-carboxylic acid; 
 4-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}phenyl)ethynyl]benzoic acid; 
 5-[2-(2-{[N-(naphthalen-1-yl)acetamido]methyl}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 3-(dimethylamino)-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[4-(cyclohex-1-en-1-yl)benzenesulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{N-[(quinolin-8-yl)methyl]formamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-3-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-3-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[4-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[4-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-(dimethylamino)-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-ethoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-2-yl}methyl)formamido]phenyl}-ethynyl)pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)-3-methylpyridine-2-carboxylic acid; 
 3-methyl-5-[2-(2-{N-[(naphthalen-2-yl)methyl]formamido}phenyl)-ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[4-methoxy-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 5-{2-[2-(9-methyl-9H-carbazole-4-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{N-[2-(naphthalen-1-yl)ethyl]formamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 N-(2-{2-[6-(3-hydroxyoxetan-3-yl)pyridin-3-yl]ethynyl}phenyl)-7-methylquinoline-8-sulfonamide; 
 5-[2-(2-{N-[(3-phenoxyphenyl)methyl]formamido}phenyl)ethynyl]pyridine-2-carboxylic acid 
 4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 N-hydroxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxamide; 
 5-{2-[4-methoxy-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methoxy-5-(2-{2-[(octahydro-1H-indole-1-sulfonyl)amino]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{N-[(6-phenylpyridin-3-yl)methyl]formamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 N-hydroxy-4-methoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxamide; 
 2-methoxy-4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 2-methoxy-4-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-benzoic acid; 
 4-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-2-(methylamino)benzoic acid; 
 5-{2-[5-(dimethylamino)-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-[2-(4-Methoxy-2,3-dimethyl-benzenesulfonylamino)-phenylethynyl]-benzoic acid; 
 4-Methoxy-naphthalene-1-sulfonic acid [4-fluoro-2-(6-methanesulfonylaminocarbonyl-pyridin-2-ylethynyl)-phenyl]-amide; 
 4-[2-(4-Methoxy-naphthalene-2-sulfonylamino)-phenylethynyl]-benzoic acid; 
 5-[2-(3-Methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(4-Methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(6-Methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(2-Methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-[2-(3-Chloro-quinoline-8-sulfonylamino)-phenylethynyl]-benzoic acid 
 5-[2-(3-Chloro-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[2-(4-methoxy-2,3,6-trimethylbenzenesulfonamido)phenyl]ethynyl}-pyridine-2-carboxylic acid; 
 4-{2-[2-(5-chloro-1-benzothiophene-2-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-{2-[4-fluoro-2-(naphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{8-oxatricyclo[7.4.0.0 2,7 ]trideca-1(9),2(7),3,5,10,12-hexaene-4-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(5-chloronaphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{2′-methyl-[1,1′-biphenyl]-4-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(6-fluoroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(3-acetamido-4-ethoxybenzenesulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{8-oxatricyclo[7.4.0.0 2,7 ]trideca-1(9),2(7),3,5,10,12-hexaene-5-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(1-methyl-1H-indole-4-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}-5-fluorophenyl)ethynyl]-3-methylpyridine-2-carboxylic acid; 
 5-[2-(5-fluoro-2-{8-oxatricyclo[7.4.0.0 2 ,7]trideca-1(9),2(7),3,5,10,12-hexaene-5-sulfonamido}phenyl)ethynyl]-3-methylpyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(2,4-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(6-chloro-2-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[5-Ethoxy-2-(quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-(2-{2-[(E)-2-phenylethenesulfonamido]phenyl}ethynyl)benzoic acid 5-(2-{2-[4-(prop-2-yn-1-yloxy)quinoline-8-sulfonamido]phenyl}-ethynyl)pyridine-2-carboxylic acid; 
 2-methoxy-5-methyl-4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}benzoic acid; 
 5-[5-Chloro-2-(4-methoxy-benzenesulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-Methoxy-5-[2-(4-methoxy-benzenesulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(5-Methoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid isopropylamide; 
 4-[2-(4-Methoxy-2,3-dimethyl-benzenesulfonylamino)-phenylethynyl]-isoquinoline-1-carboxylic acid; 
 3-(hydroxymethyl)-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 2-methoxyethyl 4-methoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 2-(2-hydroxyethoxy)ethyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 2-methoxyethyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)-phenyl]ethynyl}pyridine-2-carboxylate; 
 5-{2-[2-(5-ethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 8-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-1H,2H,3H,4H-pyrido[3,4-b]pyrazine-5-carboxylic acid; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)-5-(propan-2-yl)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(4-Dimethylamino-quinoline-8-sulfonylamino)-phenylethynyl]-4-methoxy-pyridine-2-carboxylic acid; 
 5-(2-{2-[5-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)-3-methylphenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[4-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[4-(5-methoxyquinoline-8-sulfonamido)-[1,1′-biphenyl]-3-yl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-chloro-6-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(7-ethyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-(ethylamino)-5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)-phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[2-(5,7-dimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2-methoxyethyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-Methoxy-5-[2-(4-methylamino-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(4-Dimethylamino-quinoline-8-sulfonylamino)-phenylethynyl]-4-methyl-pyridine-2-carboxylic acid; 
 5-[2-(2-{[(3-methoxyphenyl)(methyl)oxo-A6-sulfanylidene]amino}-phenyl)ethynyl]pyridine-2-carboxylic acid; 
 4-{2-[2-(4-chloroquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-{2-[2-(5,7-dimethylquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-(2-{2-[5-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)-isoquinoline-1-carboxylic acid; 
 4-[2-(2-{[methyl(oxo)(quinolin-8-yl)-A6-sulfanylidene]amino}phenyl)ethynyl]isoquinoline-1-carboxylic acid 3-Ethyl-5-[2-(5-methoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(2-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(5-Trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-Methoxy-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[5-(2,2,2-Trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 5-{5-Chloro-2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 4-Methoxy-5-{2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 5-{5-Chloro-2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-4-methoxy-pyridine-2-carboxylic acid; and 
 3-Ethyl-5-[2-(7-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid. 
 
     
     
       11. The Compound according to  claim 10 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, wherein the compound is selected from the group consisting of
 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)-4-methoxypyridine-2-carboxylic acid; 
 3-(methylamino)-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-iodo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methoxy-5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4a,8a-trans)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]-4-methoxypyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]-ethynyl}isoquinoline-1-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-[2-(5-Methoxy-quinoline-8-sulfonylamino)-5-methyl-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-Methoxy-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Methyl-2-(7-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-(ethylamino)-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2,3-dihydroxypropyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]-ethynyl}pyridine-2-carboxylate 
 5-{2-[5-ethyl-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-methyl-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-methyl-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{8-oxatricyclo[7.4.0.0 2 ,7]trideca-1(9),2(7),3,5,10,12-hexaene-6-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylate; 
 methyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[2-(9H-fluorene-2-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-(2-{2-[(decahydroquinoline-1-sulfonyl)amino]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 methyl 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylate; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methylpyridine-2-carboxylic acid; 
 4-chloro-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 4-chloro-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 methyl 4-chloro-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-(prop-1-en-2-yl)pyridine-2-carboxylic acid; 
 4-chloro-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 5-[2-(2-{[(4aR,8aS)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 ethyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 propyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 propan-2-yl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 butyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-methoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 benzyl 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-ethoxy-5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 4-ethoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[4,5-dichloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2′-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[4-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[N-({2-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-[2-(2-{[N-(naphthalen-2-yl)formamido]methyl}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-{2-[4,5-dichloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[7-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid 5-(2-{2-[N-({3-methoxy-[1,1′-biphenyl]-4-yl}methyl)formamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 4-methoxy-5-[2-(2-{[(4-methyl-decahydroquinolin-1-yl)sulfonyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4a,8a-trans)-decahydroquinoline-1-sulfonyl]amino}phenyl)ethynyl]-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-phenylpyridine-2-carboxylic acid; 
 5-{2-[2-(9-methyl-9H-carbazole-3-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[(4-methyl-decahydroquinolin-1-yl)sulfonyl]amino}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 4-{2-[5-chloro-2-(5-methoxyquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 2-(methylamino)-4-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}benzoic acid; 
 4-methoxy-5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonam ido)-phenyl]ethynyl}pyridine-2-carboxylic acid; 
 methyl 5-{2-[2-(7-methylquinoline-8-sulfonamido)-5-nitrophenyl]ethynyl}-pyridine-2-carboxylate; 
 5-{2-[5-methoxy-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(4-Chloro-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[2-(4-ethoxynaphthalene-1-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-[2-(2-{[1,1′-biphenyl]-4-sulfonamido}phenyl)ethynyl]pyridine-2-carboxylic acid; 
 5-(2-{2-[4-(propan-2-yloxy)naphthalene-1-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[2-(3,4-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4,7-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5,6,7-trimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5,7-dichloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-3-methylpyridine-2-carboxylic acid; 
 5-{2-[2-(4,7-dimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-bromo-2-chloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-bromo-4-chloroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4-chloro-7-fluoroquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 4-methoxy-5-{2-[2-(quinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Methyl-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(5-Trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Chloro-2-(4-methoxy-2,3-dimethyl-benzenesulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[5-Chloro-2-(4-methoxy-benzenesulfonylamino)-phenylethynyl]-4-methoxy-pyridine-2-carboxylic acid; 
 5-[5-Methoxy-2-(5-methoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-{2-[5-bromo-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}isoquinoline-1-carboxylic acid; 
 4-[5-Chloro-2-(4-methoxy-2,3-dimethyl-benzenesulfonylamino)-phenylethynyl]-isoquinoline-1-carboxylic acid; 
 7-methyl-N-[2-(2-{7-oxo-5H,7H-furo[3,4-b]pyridin-3-yl}ethynyl)phenyl]-quinoline-8-sulfonamide; 
 3-amino-5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(4-methoxy-2,3-dimethylbenzenesulfonamido)phenyl]-ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate 
 2,3-dihydroxypropyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)-5-methylphenyl]-ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(5-propylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-(2-{2-[5-(propan-2-yloxy)quinoline-8-sulfonamido]phenyl}ethynyl)pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-4-fluoro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(4-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[5-bromo-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic acid; 
 5-{2-[5-chloro-2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(7-ethyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-(ethylamino)-5-{2-[2-(4-methoxy-2,3-dimethylbenzenesulfonamido)-phenyl]ethynyl}pyridine-2-carboxylic acid; 
 5-{2-[2-(7-ethylquinoline-8-sulfonamido)phenyl]ethynyl}-3-(methylamino)pyridine-2-carboxylic acid; 
 5-{2-[2-(5,7-dimethylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylic acid; 
 2-methoxyethyl 4-methoxy-5-{2-[2-(7-methylquinoline-8-sulfonamido)phenyl]ethynyl}pyridine-2-carboxylate; 
 4-Methoxy-5-[2-(4-methylamino-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-{2-[2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}isoquinoline-1-carboxylic acid; 
 3-Ethyl-5-[2-(5-methoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 3-Ethyl-5-[2-(2-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-[2-(5-Trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 4-Methoxy-5-[2-(5-trifluoromethoxy-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid; 
 5-{2-[5-(2,2,2-Trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 5-{5-Chloro-2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 4-Methoxy-5-{2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-pyridine-2-carboxylic acid; 
 5-{5-Chloro-2-[5-(2,2,2-trifluoro-ethoxy)-quinoline-8-sulfonylamino]-phenylethynyl}-4-methoxy-pyridine-2-carboxylic acid; and 
 3-Ethyl-5-[2-(7-methyl-quinoline-8-sulfonylamino)-phenylethynyl]-pyridine-2-carboxylic acid. 
 
     
     
       12. A method of treatment and/or prevention of a medical condition or disease that is affected by inhibiting monocarboxylate transporters (MCT), the method comprising administering to a subject the Compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing. 
     
     
       13. The method of  claim 12  wherein the medical condition or disease is selected from the group consisting of: adenocarcinoma, adult T-cell leukemia/lymphoma, bladder cancer, blastoma, bone cancer, breast cancer, brain cancer, carcinoma, myeloid sarcoma, cervical cancer, colorectal cancer, esophageal cancer, gastrointestinal cancer, glioblastoma multiforme, glioma, gallbladder cancer, gastric cancer, head and neck cancer, Hodgkin's lymphoma, non-Hodgkin's lymphoma, intestinal cancer, kidney cancer, laryngeal cancer, leukemia, lung cancer, lymphoma, liver cancer, small cell lung cancer, non-small cell lung cancer, mesothelioma, multiple myeloma, ocular cancer, optic nerve tumor, oral cancer, ovarian cancer, pituitary tumor, primary central nervous system lymphoma, prostate cancer, pancreatic cancer, pharyngeal cancer, renal cell carcinoma, rectal cancer, sarcoma, skin cancer, spinal tumor, small intestine cancer, stomach cancer, T-cell lymphoma, testicular cancer, thyroid cancer, throat cancer, urogenital cancer, urothelial carcinoma, uterine cancer, vaginal cancer, Wilms' tumor, Crohn's disease, ulcerative colitis, idiopathic pulmonary fibrosis, muscular dystrophy, rheumatoid arthritis, systemic sclerosis (scleroderma), and Huntington's disease. 
     
     
       14. A pharmaceutical composition comprising at least one compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, as active ingredient, together with a pharmaceutically acceptable carrier. 
     
     
       15. The pharmaceutical composition comprising at least one compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof and/or the pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, as active ingredient, together with a pharmaceutically acceptable carrier, that further comprises a second active ingredient or its derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof as well as the pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios, wherein that second active ingredient is other than a compound of formula (I) as defined in  claim 1 . 
     
     
       16. A kit comprising separate packs of
 a) a composition comprising an effective amount of a compound of formula (I) according to  claim 1 , or its derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof as well as the pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all ratios; and 
 b) an effective amount of a further active ingredient that further active ingredient not being a compound of formula (I) as defined in  claim 1 . 
 
     
     
       17. A Process for manufacturing a compound according to  claim 1 , or derivatives, N-oxides, prodrugs, solvates, tautomers or stereoisomers thereof as well as the pharmaceutically acceptable salts of each of the foregoing, the process being characterized in that either
 (A) 
 (a) a compound of formula (II) 
 
       
         
           
           
               
               
           
         
         wherein 
         R 1  is —OR a ; 
         L 1  is NH or NR a ; and 
         W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8  and R a  are as defined in  claim 1 ; 
         is reacted with a compound of formula (III)
   Cl-L 2 -(L 3 ) n -A  III
 
 
         wherein 
         n is an integer selected from 0 and 1; 
         L 3  is a divalent —CH═CH— radical; 
         to form a compound of formula (I) 
       
       
         
           
           
               
               
           
         
         wherein R 1  is OR a ; 
         (b) which compound of formula (I) optionally be converted into another compound of formula (I) wherein R 1  is —OH, —NH 2 , —NHR a , —NR a R b , —N(H)OH, —N(H)O—R a , —N(H)CN, —N(H)—C(═O)—R a , —N(H)—SO 2 —R a ;
 or 
 
         (B) 
         (a) a compound of formula (IV) 
       
       
         
           
           
               
               
           
         
         wherein 
         n is an integer selected from 0 and 1; 
         L 1  is —N(CHO)—, —N(C(═O)R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )—; 
         L 2  is a divalent —CH 2 — radical; 
         L 3  is a divalent —CH 2 — radical; or 
         L 1  is a divalent —CH 2 — radical; 
         L 2  is —N(CHO)—, —N(C(═O)R a )—, —N(C(═O)—NH 2 )—, —N(C(═O)—NHR a )— or —N(C(═O)—NR a R b )—; 
         R 5 , R 6 , R 7 , R 8  and A are as defined in  claim 1 ; 
         is reacted under suitable C—C-coupling reaction conditions with a compound of formula (V) 
       
       
         
           
           
               
               
           
         
         wherein 
         R 1  is OR a ; and 
         W, R 2 , R 3 , R 4  and R a  are as defined in  claim 1 ; 
         to form a compound of formula (I) as defined above; and 
         (b) which optionally be converted into a compound of formula (I) wherein R 1  is —OH, —NH 2 , —NHR a , —NR a R b , —N(H)OH, —N(H)O—R a , —N(H)CN, —N(H)—C(═O)—R a , —N(H)—SO 2 —R a ; 
         or 
         (C) 
         (a) a compound of formula (IV) 
       
       
         
           
           
               
               
           
         
         wherein 
         n is an integer selected from 0 and 1; 
         L 2  is a divalent —N(PG)- radical with PG being a suitable protecting group, e.g., tert.-butyloxy carbonyl (BOC); 
         and 
         R 5 , R 6 , R 7 , R 8  and A are as defined for  claim 1 ; 
         is reacted under suitable C—C-coupling reaction conditions with a compound of formula (V) 
       
       
         
           
           
               
               
           
         
         wherein 
         R 1  is OR a ; and 
         W, R 2 , R 3 , R 4  and R a  are as defined in  claim 1 ; 
         to form a compound of formula (VI) 
       
       
         
           
           
               
               
           
         
         wherein 
         R 1  is OR a    
         PG is that suitable protecting group, e.g. BOC; and 
         A, W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8  and R a  are as defined in  claim 1 ; and 
         (b) which is converted into a compound of formula (VII) 
       
       
         
           
           
               
               
           
         
         wherein 
         R 1  is OR a ; and 
         A; W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8  and R a  are as defined in  claim 1 ; and 
         (c) which optionally be converted into a compound of formula (I) wherein R 1  is —OH, —NH 2 , —NHR a , —NR a R b , —N(H)OH, —N(H)O—R a , —N(H)CN, —N(H)—C(═O)—R a , —N(H)—SO 2 —R a ; 
         or 
         (D) 
         a compound of formula VIII 
       
       
         
           
           
               
               
           
         
         wherein R 1  is —OR a ; and 
         W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8  and R a  are as defined in  claim 1 ; 
         is reacted with a compound of formula (IX)
   H-L 1 -L 2 -A  IX
 
 
         wherein 
         L 1  is a divalent —N=radical; and 
         L 2  is a divalent ═S(═O)(R a )— radical; 
         A is as defined in  claim 1 ; 
         to form a compound of formula (I) 
       
       
         
           
           
               
               
           
         
         wherein R 1  is OR a ; and 
         n is 0; 
         (b) which compound of formula (I) optionally be converted into another compound of formula (I) wherein R1 is —OH, —NH2, —NHRa, —NRaRb, —N(H)OH, —N(H)O—Ra, —N(H)CN, —N(H)—C(═O)—Ra, —N(H)—SO2-Ra.