P
US12358928B2ActiveUtilityPatentIndex 59

Compounds, compositions and methods

Assignee: DENALI THERAPEUTICS INCPriority: Feb 5, 2016Filed: Aug 10, 2023Granted: Jul 15, 2025
Est. expiryFeb 5, 2036(~9.6 yrs left)· nominal 20-yr term from priority
Inventors:ESTRADA ANTHONY AFENG JIANWEN AFOX BRIANLESLIE COLIN PHILLIPLYSSIKATOS JOSEPH PPOZZAN ALFONSOSWEENEY ZACHARY KDE VICENTE FIDALGO JAVIER
C07D 498/14C07D 498/04C07D 495/04C07D 487/04C07D 471/04C07D 417/12C07D 413/14C07D 413/12C07D 403/12C07D 267/14C07D 261/18C07D 491/048C07D 513/04A61K 31/553A61K 31/551A61K 31/55A61P 25/00A61P 1/12A61P 37/02A61P 21/00A61P 1/00A61P 37/08A61P 11/06A61P 1/16A61P 19/02A61P 19/00A61P 17/02A61P 19/06A61P 11/00A61P 7/00A61P 25/32A61P 17/06A61P 21/04A61P 23/00A61P 1/18A61P 3/10A61P 37/06A61P 25/28A61P 17/00A61P 27/02A61P 1/04A61P 9/02A61P 9/00A61P 25/16A61P 3/00A61P 9/14A61P 25/14A61P 9/10A61P 31/00A61P 29/00A61P 19/10A61P 13/12A61P 1/02
59
PatentIndex Score
0
Cited by
213
References
8
Claims

Abstract

The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.

Claims

exact text as granted — not AI-modified
The invention claimed is: 
     
       1. A compound, or a pharmaceutically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof, that is chosen from: 
       
         
           
                 
                 
               
                     
                 
                   No. 
                   Structure 
                 
                     
                 
                    38A 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                    38B 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
                   200 
                   
                     
                       
                       
                           
                           
                       
                     
                   
                 
                     
                 
             
                
                
                
               
               
                
                
                
                
                
                
               
            
           
         
       
     
     
       2. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt, tautomer, stereoisomer or mixture of stereoisomers thereof of  claim 1 , and a pharmaceutically acceptable excipient. 
     
     
       3. A compound having the structure: 
       
         
           
           
               
               
           
         
         or a tautomer, stereoisomer or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. 
       
     
     
       4. A pharmaceutical composition comprising a compound of  claim 3  or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 
     
     
       5. The compound according to  claim 1 , having the structure: 
       
         
           
           
               
               
           
         
         or a tautomer, stereoisomer or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. 
       
     
     
       6. A pharmaceutical composition comprising a compound of  claim 5  or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient. 
     
     
       7. The compound according to  claim 1 , compound having the structure: 
       
         
           
           
               
               
           
         
         or a tautomer, stereoisomer or a mixture of stereoisomers thereof, or a pharmaceutically acceptable salt thereof. 
       
     
     
       8. A pharmaceutical composition comprising a compound of  claim 7  or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

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