Toll like receptor modulator compounds

Abstract

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

We claim: 
     
       1. A compound, or a pharmaceutically acceptable salt thereof, of Formula (IVa) 
       
         
           
           
               
               
           
         
         R 1  is hydrogen; 
         R 2  is hydrogen, methyl, fluoro or chloro; 
         R 3  is hydrogen or methyl; and 
         the moiety 
       
       
         
           
           
               
               
           
         
       
     
     
       2. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
 R 1  is hydrogen; 
 R 2  is hydrogen or fluoro; and 
 R 3  is hydrogen or methyl. 
 
     
     
       3. The compound of  claim 1 , or a pharmaceutically acceptable salt thereof, wherein:
 R 1  is hydrogen; 
 R 2  is hydrogen or fluoro; and 
 R 3  is hydrogen. 
 
     
     
       4. The compound of  claim 1 , selected from 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
       5. A pharmaceutical composition comprising a compound of  claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.