Device comprising microneedles for in-situ reaction of a skin

Abstract

A device including a base carrying a plurality of microneedles, and including at least one composition aimed at generating an in-situ reaction into the skin, scalp, or lips.

The invention claimed is: 
     
         1 . A device comprising a base carrying a plurality of microneedles, wherein the device includes at least one composition that generates an in-situ reaction into the skin, scalp, or lips in order to correct, supply volume, soften and/or erase skin aging signs disorders, wherein:
 the in-situ reaction transforms the at least one composition by increasing viscosity of the least one composition by binding, cross-linking, reticulation, gelification, precipitation, aggregation, association, bounding, or mixing at a time between preparation of the at least one composition and up to post-injection into the skin, scalp, or lips.   
     
     
         2 . The device of  claim 1 , wherein the microneedles are hollow. 
     
     
         3 . The device of  claim 1 , wherein the microneedles are solid. 
     
     
         4 . The device of  claim 1 , wherein the microneedles are resorbable. 
     
     
         5 . The device of the  claim 4 , wherein the microneedles are swellable. 
     
     
         6 . The device of  claim 1 , wherein the microneedles are non-resorbable. 
     
     
         7 . The device of  claim 1 , wherein the microneedles are made in a porous material. 
     
     
         8 . The device of  claim 1 , wherein a length of each microneedle is less than or equal to 50 mm. 
     
     
         9 . The device of  claim 1 , wherein each hollow microneedle has an internal volume that is less than or equal to 10 mm 3 . 
     
     
         10 . The device of  claim 1 , wherein the microneedles are configured to deliver the composition at a flow rate less than or equal to 3 cm 3 /min. 
     
     
         11 . The device of  claim 1 , wherein each microneedle comprises a stop configured for limiting the depth of injection of the microneedle into the skin to less than or equal to 500 micrometers. 
     
     
         12 . The device of  claim 1 , wherein an external largest transverse dimension of each microneedle is less than or equal to 1500 micrometers. 
     
     
         13 . The device of  claim 1 , wherein the composition is a fluid composition containing at least one material in the dispersed state in a liquid medium, said composition being solidifiable via the reaction of said material into the skin, scalp, or lips. 
     
     
         14 . The device of  claim 1 , wherein the composition comprises at least one bio-polymer, and an ion solution. 
     
     
         15 . The device of  claim 1 , wherein the microneedles are hollow and resorbable, at least part of the material in which are made the microneedles being used, once injected into the skin, scalp or lips, to generate the in-situ reaction by reacting with a composition delivered by the microneedles, the composition delivered by the microneedles comprising an alginate. 
     
     
         16 . A kit comprising a device such as defined in  claim 1  and one or several compositions aimed at generating an in-situ reaction into the skin, scalp, or lips. 
     
     
         17 . A method for preparing an injection of a composition aimed at generating an in-situ reaction into an area of skin, scalp, or lips for correcting a relief or appearance of this area, the injection being performed with the device as defined in  claim 1 , the method comprising:
 performing an acquisition of the topography of the area, and   based on such acquisition of the topography, computing a volume of composition to inject into the skin, scalp, or lips via each microneedle.   
     
     
         18 . The method of  claim 17 , wherein the computing of the volume of composition to inject further depends on the properties of reaction of the composition. 
     
     
         19 . The method of  claim 17 , wherein the composition comprises at least one bio-polymer and an ion solution, the latter being mixed before their injection in hollow microneedles. 
     
     
         20 . The method of  claim 17 , wherein the composition comprises at least one bio-polymer and an ion solution, the latter being stored in different containers and separately injected in hollow microneedles. 
     
     
         21 . The device of  claim 2 , wherein the microneedles are resorbable. 
     
     
         22 . The device of the  claim 21 , wherein the microneedles are swellable. 
     
     
         23 . The device of the  claim 15 , wherein the material in which are made the microneedles comprises a carbonate solution. 
     
     
         24 . The method of  claim 20 , wherein said at least one bio-polymer and ion solution are stored in different containers with a ratio of 50% each.