Composition for preventing, treating, or ameliorating viral infection disease, containing a complex of endoplasmic reticulum (ER) stress inhibitor and reactive oxygen species scavenger as active ingredients

Abstract

Disclosed is a composition for preventing, treating or ameliorating a viral infection disease, which is safe for human application since the safety of an ER stress inhibitor and a reactive oxygen species scavenger has already been verified. The disclosure utilizes inversely the mechanism of viruses which induces oxidative damage of a host cell and then activates viral replication and infection. Although not having direct specificity to a specific virus like existing vaccines, the composition can effectively inhibit proliferation of all viruses including oxidative stress, regardless of virus type or mutations. It can be applied as a sub-universal infection inhibitor and therapeutic agent as a limited alternative to vaccines that must be newly developed each year due to emergence of new viruses or viral mutations, and is expected to be used as a preventive agent or auxiliary agent to prevent epidemics.

The invention claimed is: 
     
         1 . A method for administering a composition comprising an ROS production inhibitor and an ROS scavenger to a subject in need of preventing or treating a viral infection disease,
 wherein the ROS scavenger is one or more selected from the group consisting of N-acetylcysteine (NAC) and superoxide dismutase 1 (SOD1),   wherein the ROS production inhibitor prevents virus infection-mediated ROS production by inhibiting activation of ROS production, and   wherein the ROS scavenger eliminates produced ROS.   
     
     
         2 . The method of  claim 1 ,
 wherein the ROS production inhibitor is 4-phenylbutyrate (4-PBA), and   wherein the ROS scavenger is superoxide dismutase 1 (SOD1) and N-acetylcysteine (NAC),   wherein N-acetylcysteine (NAC) is administered at a dosage of 1 mg or less per unit body weight (20 g) of the subject.   
     
     
         3 . The method of  claim 1 , wherein the ROS scavenger is superoxide dismutase 1 (SOD1) and N-acetylcysteine (NAC). 
     
     
         4 . The method of  claim 1 , wherein the viral infection disease is caused by one or more virus selected from the group consisting of influenza A virus, human immunodeficiency virus and coronavirus. 
     
     
         5 . The method of  claim 1 , the composition is administered via nasal route or oral route.