US12540131B2ActiveUtilityA1
N-(heteroaryl) quinazolin-2-amine derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
Est. expiryOct 25, 2039(~13.3 yrs left)· nominal 20-yr term from priority
Inventors:KEYLOR MITCHELL HARDOLINO MICHAEL JCHAU RYAN WFULLER PETER HGULATI ANMOLJOHNSON REBECCA ELIZABETHKATTAR SOLOMON DMARGREY KAILA AMORRIELLO GREGORI JNEELAMKAVIL SANTHOSH FYAN XINYU ELSIE CZARATE SAEZ CAYETANA CARMELA
C07D 417/14C07D 413/14C07D 409/14C07D 405/14C07D 403/12C07D 401/14C07D 403/14A61P 25/16A61K 31/517
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Claims
Abstract
The present invention is directed to substituted certain N-(heteroaryl)quinazolin-2-amine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein J, R3, and R4, are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.
Claims
exact text as granted — not AI-modifiedWe claim:
1 . A compound represented by structural Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
J is selected from:
R 1 is independently selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, halogen, CN, and cyclopropyl;
R 2 is independently selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —((C 1 -C 6 )alkyl)) n (C 3 -C 8 )cycloalkyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, and said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 ;
R 3 is selected from CH 3 , CF 3 , OCH 3 , Cl, CN, and cyclopropyl; and
R 4 is selected from (C 3 -C 6 )cycloalkyl, piperidinyl, pyrrolidinyl, spiropentanyl, spirohexanyl, azaspiroheptanyl, azabicycloheptanyl, azabicylcooctanyl, and oxaazabicyclononanyl, said cycloalkyl, piperidinyl, pyrrolidinyl, spiropentanyl, spirohexanyl, azaspiroheptanyl, azabicycloheptanyl, azabicylcooctanyl, and oxaazabicyclononanyl optionally substituted with 1 to 3 groups of R b ,
R b is selected from hydrogen, (C 1 -C 6 )alkyl, OH, (CH 2 ) n (C 3 -C 6 )cycloalkyl, halogen, (C 1 -C 6 )haloalkyl, C(O)(C 1 -C 6 )alkyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, (CH 2 ) n oxanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl, said alkyl, cycloalkyl, oxetanyl, oxolanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl optionally substituted with 1 to 3 groups of R b1 ;
R b1 is selected from (C 1 -C 6 )alkyl, O(C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, OH, halogen, CN, CF 3 , phenyl, oxazolidinonyl, pyrrolidinonyl, and morpholinyl, said phenyl and alkyl optionally substituted with 1 to 2 groups of halogen and CN; and
n is 0, 1, 2, 3, or 4.
2 . A compound, or a pharmaceutically acceptable salt thereof represented by structural Formula I′:
wherein X is N and Y is C, or X is C and Y is S,
such that the moiety
is selected from
R 1 S
R 1 is selected from H, Cl, and CH 3 ;
R 2 is selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-OH, -(C 1 -C 6 ) haloalkyl-OH, —(C 1 -C 6 )alkyl-CN, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 ) haloalkyl,
—(C 3 -C 6 )cycloalkyl,
—(C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl,
—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
bicycloalkyl;
bicycloalkyl which is substituted with 1 or 2 groups independently selected from halogen, C(O)(C 1 -C 6 )alkyl, C(O) O(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-OH, (C 1 -C 6 )alkyl-CN, C(O) NH (C 1 -C 6 )alkyl, C(O) N ((C 1 -C 6 )alkyl) 2 , C(O) N ((C 1 -C 6 )alkyl)-O-((C 1 -C 6 )alkyl), (C 1 -C 6 )haloalkyl, (C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl-O-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl-O-(C 1 -C 6 )haloalkyl, (C 1 -C 6 )haloalkyl-O-(C 1 -C 6 )haloalkyl, cyclopropyl, and cyclobutyl;
oxetanyl,
oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
tetrahydrofuranyl,
tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-oxetanyl,
—(C 1 -C 3 )alkyl-oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-tetrahydrofuranyl,
—(C 1 -C 3 )alkyl-tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
wherein R 2E is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl,
wherein:
R 2F is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 ) fluoroalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl,
R 3 is selected from CH 3 , CF 3 , OCH 3 , Cl, CN, and cyclopropyl; and
R 4 is selected from (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl substituted with 1 or 2 fluorine atoms,
wherein:
q is 1 or 2;
R a is selected from H, F, and OH;
R c is selected from H, F, CN, OH, —(C 1 -C 6 )alkyl, and O(C 1 -C 4 )alkyl;
R b is selected from H, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-OH, —(C 1 -C 6 )alkyl-CN, —(C 1 -C 6 )haloalkyl-OH, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )haloalkyl, -(C 3 -C 6 )cycloalkyl,
—(C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, (C 1 -C 6 )alkyl, and O(C 1 -C 4 )alkyl,
—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl,
—(C 1 -C 3 )alkyl (C 3 -C 6 )cycloalkyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
oxetanyl,
oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-oxetanyl,
—(C 1 -C 3 )alkyl-oxetanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
tetrahydrofuranyl,
tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-tetrahydrofuranyl,
—(C 1 -C 3 )alkyl-tetrahydrofuranyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
thietanyl,
thietanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-thietanyl,
—(C 1 -C 3 )alkyl-thietanyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
thietanyl 1,1-dioxide,
thietanyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-thietanyl 1,1-dioxide,
—(C 1 -C 3 )alkyl-thietanyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
tetrahydrothiophenyl,
tetrahydrothiophenyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-tetrahydrothiophenyl,
—(C 1 -C 3 )alkyl-tetrahydrothiophenyl which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
tetrahydrothiophenyl 1,1-dioxide,
tetrahydrothiophenyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl,
—(C 1 -C 3 )alkyl-tetrahydrothiophenyl 1,1-dioxide, and
—(C 1 -C 3 )alkyl-tetrahydrothiophenyl 1,1-dioxide which is substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, and —(C 1 -C 6 )alkyl.
3 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 is selected from Cl, CH 3 , and CN.
4 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is selected from:
5 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is selected from:
R 1 is selected from H, Cl, and CH 3 ; and R 2 is independently selected from —(C 1 -C 6 )alkyl, -(C 1 -C 6 ) haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 or 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, -(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 .
6 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein J is
R 1 is selected from H, Cl, and CH 3 ; and R 2 is independently selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 )haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 .
7 . The compound according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 4 is selected from cyclopropyl, cyclohexyl, azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl, said cyclopropyl, cyclohexyl, azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from (C 1 -C 6 )alkyl, OH, (CH 2 ) n (C 3 -C 6 )cycloalkyl, halogen, (C 1 -C 6 )haloalkyl, C(O)(C 1 -C 6 )alkyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, (CH 2 ) n oxanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl, said alkyl, cycloalkyl, oxetanyl, oxolanyl, tetrahydrothiophenedionyl, thietanedionyl, oxaspirooctanyl, and bicyclohexanyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.
8 . The compound according to claim 1 wherein R 4 is selected from azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl said azaspiroheptanyl, spiropentanyl, spirohexanyl, azabicycloheptanyl, azabicyclooctanyl, and oxaazabicyclononanyl, pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.
9 . The compound according to claim 1 wherein R 4 is selected from pyrrolidinyl, and piperidinyl, said pyrrolidinyl, and piperidinyl optionally substituted with 1 to 3 groups selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.
10 . The compound according to claim 1 represented by structural Formula II:
or a pharmaceutically acceptable salt thereof, wherein J, R 3 , and R b are as described and R b2 is independently selected from C 1-6 alkyl and halogen.
11 . The compound according to claim 10 wherein R b2 is independently selected from C 1-6 alkyl and halogen, R 3 is selected from Cl, CH 3 , CF 3 , and CN, and J is selected from:
12 . The compound according to claim 10 wherein R 1 is selected from H, -CH 3 , -C(CH 3 ) 3 , -CHF 2 , CF 3 , Br, Cl, CN, and cyclopropyl, and R 2 is selected from —(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, (CH 2 ) n cyclopropyl, (CH 2 ) n cyclobutyl, bicyclopentanyl, spiroheptanyl, azaspiroheptanyl, (CH 2 ) n oxetanyl, (CH 2 ) n oxolanyl, thiazolyl, and piperidinyl, said alkyl, haloalkyl, cycloalkyl, and bicyclopentanyl optionally substituted with 1, 2, or 3 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkylOH, O-(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-O-(C 1 -C 6 )alkyl, and -O-(C 1 -C 6 ) haloalkyl, said spiroheptanyl, azaspiroheptanyl, oxetanyl, oxolanyl, thiazolyl, and piperidinyl optionally substituted with 1 to 2 groups independently selected from halogen, OH, CN, —(C 1 -C 6 )alkyl, -(CH 2 ) n O(C 1 -C 6 )alkyl, —(C 1 -C 6 )haloalkyl, oxolanyl, and oxetanyl, said oxolanyl and oxetanyl optionally substituted with 1 to 2 groups of CH 3 , wherein n is 0-3.
13 . The compound according to claim 10 wherein R b is selected from CH 3 , CH 2 C(CH 3 ) 2 OH, oxetanyl, oxolanyl, and thietanedionyl, said oxetanyl, oxolanyl, and thietanedionyl optionally substituted with 1 to 3 groups of R b1 selected from CH 3 , OH, OCH 3 , CF 3 , Fl, Cl, CN, CH 2 CN, and cyclopropyl.
14 . The compound of claim 1 , or a pharmaceutically acceptable salt thereof selected from:
(S) 6-chloro-N-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-7-(spiro[2.2]pentan-1-yl)quinazolin-2-
amine
(R) 6-chloro-N-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-7-(spiro[2.2]pentan-1-yl)quinazolin-2-
amine
(S) 1-(3-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)pyrrolidin-1-
yl)-2-methylpropan-2-ol
(R) 1-(3-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)pyrrolidin-1-
yl)-2-methylpropan-2-ol
(1R,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)cyclobutan-1-ol
(1R,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)cyclobutan-1-ol
(1S,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)cyclobutan-1-ol
(1S,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)cyclobutan-1-ol
(3R,4R)-4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S)-4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S) 1-(3-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}pyrrolidin-1-
yl)-2-methylpropan-2-ol
(R) 1-(3-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}pyrrolidin-1-
yl)-2-methylpropan-2-ol
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(3S,4S) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
cis or trans-4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)-1-methylcyclohexan-1-ol
cis or trans-4-(6-chloro-2-((1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-1-
methylcyclohexan-1-ol
(1R,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-2-methylcyclopentan-1-ol
(1S,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-2-methylcyclopentan-1-ol
(1S,2S) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-2-methylcyclopentan-1-ol
(1R,2R) 2-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-2-methylcyclopentan-1-ol
(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(2,2-
difluorocyclopentyl)piperidin-4-yl]quinazolin-2-amine
(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(2,2-
difluorocyclopentyl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 4-(4-{6-chloro-2-[(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3S,4S)-4-(4-(6-chloro-2-((5-methyl-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R)-4-(4-(6-chloro-2-((5-methyl-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S)-4-(4-(6-chloro-2-((5-chloro-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R)-4-(4-(6-chloro-2-((5-chloro-1-(methyl-d3)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 1-(5-chloro-4-((6-chloro-7-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-
yl)quinazolin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol
(3R,4R) 1-(5-chloro-4-((6-chloro-7-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-
yl)quinazolin-2-yl)amino)-1H-pyrazol-1-yl)-2-methylpropan-2-ol
6-chloro-N-(1-(3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-7-(1-(3-
methyloxetan-3-yl)piperidin-4-yl)quinazolin-2-amine
(3S,4S)-(4-(4-(2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)-(4-(4-(2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(S) 6-chloro-N-{1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-
(spiro[2.2]pentan-1-yl)quinazolin-2-amine
(R) 6-chloro-N-{1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-
(spiro[2.2]pentan-1-yl)quinazolin-2-amine
(S) 6-chloro-N-{1-[2-(3-methyloxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl]-1H-pyrazol-4-yl}-
7-(spiro[2.2]pentan-1-yl)quinazolin-2-amine
(R) 6-chloro-N-{1-[2-(3-methyloxetan-3-yl)-2-azaspiro[3.3]heptan-6-yl]-1H-pyrazol-4-yl}-
7-(spiro[2.2]pentan-1-yl)quinazolin-2-amine
(S) 6-chloro-N-{5-chloro-1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-
(spiro[2.3]hexan-1-yl)quinazolin-2-amine
(R) 6-chloro-N-{5-chloro-1-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-1H-pyrazol-4-yl}-7-
(spiro[2.3]hexan-1-yl)quinazolin-2-amine
6-chloro-N-[5-chloro-1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-
fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-{5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-
fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-
fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-{5-chloro-1-[(3-methyloxetan-3-yl)methyl]-1H-pyrazol-4-yl}-7-[3-
fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-{5-chloro-1-[2-(difluoromethoxy)-2-methylpropyl]-1H-pyrazol-4-yl}-7-[1-
(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-[1-(2-methoxy-2-methylpropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
1-{[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-methyl-1H-
pyrazol-1-yl]methyl}cyclopropane-1-carbonitrile
6-chloro-N-[1-(2-methoxy-2-methylpropyl)-3-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
1-{[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-3-methyl-1H-
pyrazol-1-yl]methyl}cyclopropane-1-carbonitrile
N-(1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl)-6-chloro-7-(1-(3-methyloxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
2-[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-methyl-1H-
pyrazol-1-yl]-2-methylpropanenitrile
2-[4-({6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-5-
methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]-6-chloro-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]-6-chloro-7-[1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-[5-methyl-1-(oxolan-3-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(R) 6-chloro-N-[5-methyl-1-(oxolan-3-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(S) 6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-N-[5-methyl-1-(oxolan-3-yl)-1H-
pyrazol-4-yl]quinazolin-2-amine
(R) 6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]-N-[5-methyl-1-(oxolan-3-yl)-1H-
pyrazol-4-yl]quinazolin-2-amine
(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-{1-[3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl]-5-methyl-1H-pyrazol-4-yl}-
7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-{1-[3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl]-5-methyl-1H-pyrazol-4-yl}-
7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4S) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
1H-pyrazol-1-yl]oxolan-3-ol
(3S,4R) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
1H-pyrazol-1-yl]oxolan-3-ol
(3R,4R) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl(amino)-
1H-pyrazol-1-yl]oxolan-3-ol
(3S,4S) 4-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
1H-pyrazol-1-yl]oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolane-3-carbonitrile
(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolane-3-carbonitrile
(3S,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolane-3-carbonitrile
(3R,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolane-3-carbonitrile
(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}piperidin-1-
yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}piperidin-1-
yl)oxolan-3-ol
6-chloro-N-[1-[3-(2-methoxypropan-2-yl)bicyclo[1.1.1]pentan-1-yl]-1H-pyrazol-4-yl}-7-
[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
{3-[4-({6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]bicyclo[1.1.1]pentan-1-yl}methanol
2-{3-[4-({6-chloro-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]bicyclo[1.1.1]pentan-1-yl}propan-2-ol
6-chloro-N-(1-{3-[(dimethylamino)methyl]bicyclo[1.1.1]pentan-1-yl}-1H-pyrazol-4-yl)-7-
[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(1-{3-[(3,3-difluoroazetidin-1-yl)methyl]bicyclo[1.1.1]pentan-1-yl}-1H-
pyrazol-4-yl)-7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
1-[4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-3-methyl-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
6-chloro-N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
cis- or trans- 4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-1-methylcyclohexan-1-ol
cis- or trans- 4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}-1-methylcyclohexan-1-ol
(3S,4S) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-
1-yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}piperidin-
1-yl)oxolan-3-ol
(3S,4S) 4-(4-(6-chloro-2-((3-methyl-1-(methyl-d 3 )-1H-pyrazol-5-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((3-methyl-1-(methyl-d 3 )-1H-pyrazol-5-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(methyl-d 3 )-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(methyl-d 3 )-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S) 4-(4-(6-chloro-2-((5-methyl-1-(methyl-d 3 )-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((5-methyl-1-(methyl-d 3 )-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
6-chloro-N-(5-chloro-1-(methyl-d 3 )-1H-pyrazol-4-yl)-7-(1-(3-methyloxetan-3-yl)piperidin-
4-yl)quinazolin-2-amine
(S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 2-[4-({6-chloro-7-[1-(4-hydroxyoxolan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
(3R,4R) 2-[4-({6-chloro-7-[1-(4-hydroxyoxolan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-3-methyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3R,4R) 4-(4-{2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-(4-{2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-yl}piperidin-
1-yl)oxolan-3-ol
(3R,4R) 4-(4-{2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3S,4S) 4-(4-{2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-yl}piperidin-
1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(1,5-dimethyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[5-(difluoromethyl)-1-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R) 4-[4-(6-chloro-2-{[5-(difluoromethyl)-1-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-chloroquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-chloroquinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-1H-pyrazol-5-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) 5-({6-chloro-7-[1-(4-hydroxy-3-methyloxolan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1,3-dimethyl-1H-pyrazole-4-carbonitrile
(3R,4R) 5-({6-chloro-7-[1-(4-hydroxy-3-methyloxolan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1,3-dimethyl-1H-pyrazole-4-carbonitrile
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S)-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R) 4-[4-(6-chloro-2-{[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-
yl]amino(quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S) 4-(4-(6-chloro-2-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)amino)quinazolin-
7-yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-olyl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R) 4-(4-(6-chloro-2-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-olyl)piperidin-1-yl]-4-
methyloxolan-3-ol
(3S,4S) 4-[4-(6-chloro-2-{[1-cyclopropyl-5-(difluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R) 4-[4-(6-chloro-2-{[1-cyclopropyl-5-(difluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(7R) 6-chloro-N-(5-chloro-1-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-yl)-1H-
pyrazol-4-yl)-7-(2,2-difluorocyclopropyl)quinazolin-2-amine
(3S,4S)(7S) 6-chloro-N-(5-chloro-1-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-yl)-1H-
pyrazol-4-yl)-7-(2,2-difluorocyclopropyl)quinazolin-2-amine
(3R,4R)(7R) 6-chloro-N-(5-chloro-1-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-yl)-1H-
pyrazol-4-yl)-7-(2,2-difluorocyclopropyl)quinazolin-2-amine
(3R,4R)(7S) 6-chloro-N-(5-chloro-1-(3-fluoro-1-(3-methyloxetan-3-yl)piperidin-4-yl)-1H-
pyrazol-4-yl)-7-(2,2-difluorocyclopropyl)quinazolin-2-amine
(3S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoropiperidin-4-
yl)quinazolin-2-amine
(3R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoropiperidin-4-
yl)quinazolin-2-amine
1-(5-chloro-4-((6-chloro-7-(1-(oxetan-3-yl)piperidin-4-yl)quinazolin-2-yl)amino)-1H-
pyrazol-1-yl)-2-methylpropan-2-ol
(3S,4S) 1-(5-chloro-4-((6-chloro-7-(1-ethyl-3-fluoropiperidin-4-yl)quinazolin-2-yl)amino)-
1H-pyrazol-1-yl)-2-methylpropan-2-ol
(3R,4R) 1-(5-chloro-4-((6-chloro-7-(1-ethyl-3-fluoropiperidin-4-yl)quinazolin-2-yl)amino)-
1H-pyrazol-1-yl)-2-methylpropan-2-ol
(S) 3-(4-(6-chloro-2-((5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrothiophene 1,1-dioxide
(S) 3-(4-(6-chloro-2-((5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrothiophene 1,1-dioxide
6-chloro-N-(5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl)-7-(1-
(trifluoromethyl)piperidin-4-yl)quinazolin-2-amine
1-((2S)-4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-2-
methylpiperidin-1-yl)ethan-1-one
4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)quinazolin-
7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(R)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(R)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(R)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahy drofuran-3-ol
(R)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(S)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(S)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(S)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(S)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3S,4S)(3S,4S) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3S,4S)(3R,4R) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3R,4R)(3S,4S) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3R,4R)(3R,4R) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3S,4S)(3S,4S) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3S,4S)(3R,4R) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3R,4R)(3S,4S) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3R,4R)(3R,4R) 4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R) 3-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol
(S) 3-(4-(6-chloro-2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol
3-(4-(6-chloro-2-((5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)thietane 1,1-dioxide
6-chloro-N-(5-chloro-1-cyclobutyl-1H-pyrazol-4-yl)-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-
4-yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(oxetan-3-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[1-(difluoromethyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(cyclobutylmethyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-{1-[(3-methyloxetan-3-
yl)methyl]piperidin-4-yl}quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(1-(oxetan-3-yl-2,2,4,4-
d4)piperidin-4-yl)quinazolin-2-amine
(3S,4S) 1-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylpropan-2-ol
3R,4R) 1-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylpropan-2-ol
6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[4-fluoro-1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)pyrrolidin-3-yl]quinazolin-2-amine
(S) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)pyrrolidin-3-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-1-methylpiperidin-3-ol
(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-1-methylpiperidin-3-ol
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[4-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]quinazolin-2-amine
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(oxetan-3-yl)pyrrolidin-3-
yl]quinazolin-2-amine
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(oxetan-3-yl)pyrrolidin-3-
yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(4-fluoro-1-methylpiperidin-4-
yl)quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-(oxetan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-(oxetan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoro-1-
methylpiperidin-4-yl)quinazolin-2-amine
(3R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoro-1-
methylpiperidin-4-yl)quinazolin-2-amine
(3S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoro-1-
methylpiperidin-4-yl)quinazolin-2-amine
(3R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(3-fluoro-1-
methylpiperidin-4-yl)quinazolin-2-amine
(3S,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[4-fluoro-1-(oxetan-3-
yl)pyrrolidin-3-yl]quinazolin-2-amine
(3R,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[4-fluoro-1-(oxetan-3-
yl)pyrrolidin-3-yl]quinazolin-2-amine
(3S,4S) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
6-chloro-N-(3-methyl-1,2-thiazol-5-yl)-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
amine
(2R,3R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(2-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(2S,3S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(2-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(2S,3R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(2-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(2R,3S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(2-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(oxolan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(oxolan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(3S,4S) 6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-N-(3-methyl-1,2-thiazol-5-
yl)quinazolin-2-amine
(3R,4R) 6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-N-(3-methyl-1,2-thiazol-5-
yl)quinazolin-2-amine
(3S,4S) 6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)-N-(3-methyl-1,2-thiazol-5-
yl)quinazolin-2-amine
(3R,4R) 6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)-N-(3-methyl-1,2-thiazol-5-
yl)quinazolin-2-amine
6-chloro-N-[1-(2-fluoroethyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(1-(oxetan-3-yl-3-d)piperidin-4-
yl)quinazolin-2-amine
1-(5-chloro-4-((6-chloro-7-(1-(oxetan-3-yl-d5)piperidin-4-yl)quinazolin-2-yl)amino)-1H-
pyrazol-1-yl)-2-methylpropan-2-ol
1-(5-chloro-4-((6-chloro-7-(1-(oxetan-3-yl-3-d)piperidin-4-yl)quinazolin-2-yl)amino)-1H-
pyrazol-1-yl)-2-methylpropan-2-ol
(R)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(R)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylbutan-2-ol
(R) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylbutan-2-ol
(3S,4S) 1-[4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(R)(3S,4S) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(R)(3R,4R) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-
2-yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(S)(3S,4S) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(S)(3R,4R) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-
2-yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(R)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(R)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylbutan-2-ol
(R) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylbutan-2-ol
(S)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(R)(3R,4R) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(R)(3S,4S) 3-(5-chloro-4-{[6-chloro-7-(3-fluoro-1-methylpiperidin-4-yl)quinazolin-2-
yl]amino}-1H-pyrazol-1-yl)-2-methylbutan-2-ol
(S)(3R,4R) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-
2-yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(S)(3S,4S) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(R)(3R,4R) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-
2-yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
(R)(3S,4S) 3-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylbutan-2-ol
1-[5-chl oro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2R,3S) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2S,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2R,3S) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2S,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2S,3S) 1-[5-chloro-4-([6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2R,3R) l-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2S,3S) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2R,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
1-(5-chloro-4-{[6-chloro-7-(1-methylpiperidin-4-yl)quinazolin-2-yl]amino}-1H-pyrazol-1-
yl)-2-methylpropan-2-ol
1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2R,3S)1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2S,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2R,3S) 1-[5-chloro-4-([6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2S,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2S,3S) 1-[5-chloro-4-([6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R)(2R,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2S,3S) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl(amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S)(2R,3R) 1-[5-chloro-4-({6-chloro-7-[3-fluoro-1-(2-methyloxetan-3-yl)piperidin-4-
yl]quinazolin-2-yl(amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(2R,3R) 1-[5-chloro-4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(2S,3S) 1-[5-chloro-4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(2S,3R) 1-[5-chloro-4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(2R,3S) 1-[5-chloro-4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(S) 1-[5-chloro-4-({6-chloro-7-[1-(oxolan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
(R) 1-[5-chloro-4-({6-chloro-7-[1-(oxolan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
1-[(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)methyl]cyclopropane-1-carbonitrile
(S) 1-[5-chloro-4-({6-chloro-7-[1-(oxolan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
(R) 1-[5-chloro-4-({6-chloro-7-[1-(oxolan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
1-[5-chloro-4-({6-methyl-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S) 1-[5-chloro-4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[5-chloro-4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3S,4S) 1-[5-chloro-4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[5-chloro-4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-
yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol
N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-6-methyl-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
1-[5-chloro-4-({6-chloro-7-[4-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl(amino)-
1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclobutyl-1H-pyrazol-4-yl)-7-(piperidin-4-yl)quinazolin-2-amine
6-chloro-N-[5-chloro-1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-7-(piperidin-4-
yl)quinazolin-2-amine
(3S,4S) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-(3-
fluoropiperidin-4-yl)quinazolin-2-amine
(3R,4R) 6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-(3-
fluoropiperidin-4-yl)quinazolin-2-amine
6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-(piperidin-4-yl)quinazolin-
2-amine
1-(5-chloro-4-{[6-chloro-7-(piperidin-4-yl)quinazolin-2-yl]amino}-1H-pyrazol-1-yl)-2-
methylpropan-2-ol
3-[4-(6-chloro-2-{[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]amino}quinazolin-7-
yl)piperidin-1-yl]propanenitrile
3-(4-(6-chloro-2-((3-methylisothiazol-5-yl)amino)quinazolin-7-yl)piperidin-1-yl)thietane
1,1-dioxide
1-(5-chloro-4-{[6-chloro-7-(1-ethylpiperidin-4-yl)quinazolin-2-yl]amino}-1H-pyrazol-1-
yl)-2-methylpropan-2-ol
6-chloro-N-[5-chloro-1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-7-[1-(3-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 3-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)thietane 1,1-dioxide
(3R,4R) 3-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)thietane 1,1-dioxide
(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-carbonitrile
(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-carbonitrile
(3S,4R) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-carbonitrile
(3R,4S) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-carbonitrile
(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)tetrahydrofuran-3-ol
(2S,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(2R,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(2S,4R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(2R,4S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-methyl-1-(oxetan-3-
yl)piperidin-4-yl)quinazolin-2-amine
(1R,3S)-3-((35,45) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1S,3R)-3-((3S,4S) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1R,3R)-3-((3S,4S) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1S,3S)-3-((3S,4S) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1R,3S)-3-((3R,4R) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1S,3R)-3-((3R,4R) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
(1R,3R)-3-((3R,4R) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
1S,3S)-3-((3R,4R) 4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)cyclopentane-1-carbonitrile
cis or trans 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(8-(oxetan-3-yl)-8-
azabicyclo[3.2.1]octan-3-yl)quinazolin-2-amine
cis or trans 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(9-(oxetan-3-yl)-3-oxa-
9-azabicyclo[3.3.1]nonan-7-yl)quinazolin-2-amine
(R) 7-(1-(5-oxaspiro[3.4]octan-7-yl)piperidin-4-yl)-6-chloro-N-(5-chloro-1-cyclopropyl-
1H-pyrazol-4-yl)quinazolin-2-amine
(S) 7-(1-(5-oxaspiro[3.4]octan-7-yl)piperidin-4-yl)-6-chloro-N-(5-chloro-1-cyclopropyl-
1H-pyrazol-4-yl)quinazolin-2-amine
(S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(1-(5,5-
dimethyltetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(1-(5,5-
dimethyltetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
cis or trans 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2,6-dimethyl-1-
(oxetan-3-yl)piperidin-4-yl)quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(2-(oxetan-3-yl)-2-
azaspiro[3.3]heptan-6-yl)quinazolin-2-amine
4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-{6-chloro-2-[(4-chloro-3-methyl-1,2-thiazol-5-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
3-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)thietane 1,1-dioxide
(R)(3S,4S) 3-[4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]thietane 1,1-dioxide
(S)(3R,4R) 3-[4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]thietane 1,1-dioxide
(S)(3S,4S) 3-[4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]thietane 1,1-dioxide
4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}quinazolin-7-
yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S)4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R)4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S)4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(1S,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[2-(oxetan-3-yl)-2-
azabicyclo[2.2.1]heptan-5-yl]quinazolin-2-amine
(1R,4R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[2-(oxetan-3-yl)-2-
azabicyclo[2.2.1]heptan-5-yl]quinazolin-2-amine
4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl]oxolan-3-ol
(3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-yl}-2-
methylpiperidin-1-yl]oxolan-3-ol
(3S,4S)(2S,4R) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3S,4S)(2S,4S) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3R,4R)(2S,4R) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3R,4R)(2S,4S) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3S,4S)(2S,4R) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3S,4S)(2S,4S) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3R,4R)(2S,4R) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3R,4R)(2S,4S) (3 4-[4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3S,4S) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3R,4R) 4-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(2R,3R) 2-[4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
(2S,3S) 2-[4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
(2S,3R) 2-[4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
(2R,3S) 2-[4-({6-chloro-7-[1-(2-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropanenitrile
4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-yl}-3-
fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) a4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3R4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-l)piperidin-1-yl]oxolan-3-ol
(S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-ethyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R)4-[4-(2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
3R,4R)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-
methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino)-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino)-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(1S,2R)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3S,4S) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3R,4R) 2-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3S,4S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2R)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2S)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1R,2R)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(1S,2S)(3R,4R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)cyclopentan-1-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(R)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(S)(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,5R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(5-cyclopropyloxolan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,5R) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(5-cyclopropyloxolan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(3R,5S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(5-cyclopropyloxolan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,5S) 6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(5-cyclopropyloxolan-
3-yl)piperidin-4-yl]quinazolin-2-amine
(1R,3R) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1S,3R) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1R,3S) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1S,3S) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1R,3R) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1S,3R) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1R,3S) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
(1S,3S) [3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)cyclopentyl]acetonitrile
7-{1-[(1S,5R)-bicyclo[3.1.0]hexan-2-yl]piperidin-4-yl}-6-chloro-N-(1-cyclopropyl-5-
methyl-1H-pyrazol-4-yl)quinazolin-2-amine
(R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(5,5-dimethyloxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(5,5-dimethyloxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(R)(3S,4S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[(3R,4R)-
3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
((S)(3S,4S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-
[(3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3R,4R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-
[(3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3R,4R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-
[(3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3S,4S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[(3R,4R)-
3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3S,4S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[(3R,4R)-
3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3R,4R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-
[(3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3R,4R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-
[(3R,4R)-3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(R)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-olyl]amino}quinazolin-
7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3S,4S) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(S)(3R,4R) 4-[4-(6-chloro-2-{[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(R)(3R,4R)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3S,4S)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3S,4S) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(S)(3R,4R)(3R,4R) 4-(6-chloro-2-{[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
((3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(2R)(3S) 1-(3-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}pyrrolidin-1-yl)-2-hydroxypropan-1-one
(2R)(3R) 1-(3-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}pyrrolidin-1-yl)-2-hydroxypropan-1-one
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(2S)(3S) 1-(3-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}pyrrolidin-1-yl)-2-hydroxypropan-1-one
(2S)(3R) 1-(3-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}pyrrolidin-1-yl)-2-hydroxypropan-1-one
(S) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4,4,4-trifluorobutan-2-ol
(R) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4,4,4-trifluorobutan-2-ol
(S) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4,4,4-trifluorobutan-2-ol
(R) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-4,4,4-trifluorobutan-2-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-phenylethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3-chlorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3-fluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3-fluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3,5-difluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3,5-difluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(3,4-difluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,4-difluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2-fluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2-fluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,5-difluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,5-difluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,3-difluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,3-difluorophenyl)ethan-1-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,6-difluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(2,6-difluorophenyl)ethan-1-ol
4-[(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)methyl]oxan-4-ol
(2R)-1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-methoxypropan-2-ol
(2S)-1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-methoxypropan-2-ol
(1R)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-fluorophenyl)ethan-1-ol
(1S)-2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-fluorophenyl)ethan-1-ol
1-[(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)methyl]cyclobutan-1-ol
1-[(2S)-3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-hydroxypropyl]pyrrolidin-2-one
1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-methylpropan-2-ol
(S) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-phenylpropan-2-ol
(R) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-phenylpropan-2-ol
(S) 4-[2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-hydroxyethyl]benzonitrile
(R) 4-[2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-hydroxyethyl]benzonitrile
(S) 3-[3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-hydroxypropyl]-1,3-oxazolidin-2-one
(R) 3-[3-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-hydroxypropyl]-1,3-oxazolidin-2-one
(S) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-phenylpropan-2-ol
(R) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-2-phenylpropan-2-ol
(S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-chlorophenyl)ethan-1-ol
(R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-chlorophenyl)ethan-1-ol
(S) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-chlorophenyl)ethan-1-ol
(R) 2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-(4-chlorophenyl)ethan-1-ol
(S) 4-[2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-hydroxyethyl]benzonitrile
(R) 4-[2-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-1-hydroxyethyl]benzonitrile
(S) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-(morpholin-4-yl)propan-2-ol
(R) 1-(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)-3-(morpholin-4-yl)propan-2-ol
trans-3-[(4-{6-chloro-2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)methyl]-3-hydroxycyclobutane-1-carbonitrile
4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)quinazolin-
7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(R)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(S)(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-
yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-[4-(6-chloro-2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(6-chloro-2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(6-chloro-2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(6-chloro-2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[5-chloro-1-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1H-pyrazol-4-
yl]amino}-6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl]-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-3-
fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]quinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-methyl-1H-pyrazol-4-yl)amino]quinazolin-
7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-cyclopropyl-1-methyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(2S) 4-[4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-
7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(3R,4R)(2S) 4-[4-{2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-
7-yl}-2-methylpiperidin-1-yl]oxolan-3-ol
(R)(3S,4S)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4S)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-chloroquinazolin-
7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-
chloroquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-
chloroquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-
chloroquinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(R)(3S,4S)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4S)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3S,4S) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3R,4R) N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3R,4R)N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-
yl)amino]quinazolin-7-yl}-3-fluoropiperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(6-chloro-2-{[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-
yl]amino}quinazolin-7-yl)-3-fluoropiperidin-1-yl]-4-methyloxolan-3-ol
(3S,4S)(3S,4S)) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)quinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-
3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-3-
fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(2-((1,5-dimethyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-yl)-
3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-
7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(2-((5-chloro-1-methyl-1H-pyrazol-4-yl)amino)-6-methylquinazolin-
7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
methoxyoxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3S,4S)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3S,4S) 4-(4-(6-chloro-2-((5-chloro-1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
(3R,4R)(3R,4R) 4-(4-(6-chloro-2-((5-chloro-1-(3-methoxybicyclo[1.1.1]pentan-1-yl)-1H-
pyrazol-4-yl)amino)quinazolin-7-yl)-3-fluoropiperidin-1-yl)tetrahydrofuran-3-ol
3-(4-(6-methyl-2-((5-methyl-1-(1-methylcyclopropyl)-1H-pyrazol4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)propanenitrile
3-(4-(2-((5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl)amino)-6-methylquinazolin-7-
yl)piperidin-1-yl)propanenitrile
(3S,4S) N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3R,4R) N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3S,4S) N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3R,4R) N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(oxetan-3-yl)piperidin-
4-yl]-6-methylquinazolin-2-amine
(3S,4S) 1-[4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S) 1-[4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3R,4R) 1-[4-({7-[3-fluoro-1-(oxetan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-yl}amino)-
5-methyl-1H-pyrazol-1-yl]-2-methylpropan-2-ol
(3S,4S) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
(3R,4R) 4-(4-{2-[(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino]-6-methylquinazolin-7-
yl}piperidin-1-yl)oxolan-3-ol
N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-methyl-1H-pyrazol-4-yl]-6-methyl-7-[1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S)(3S,4S) 4-(4-{2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3R,4R) 4-(4-{2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3S,4S) 4-(4-{2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3R,4R)(3R,4R) 4-(4-{2-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-
3-fluoropiperidin-1-yl)oxolan-3-ol
(3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4-(4-{2-[(1,3-
dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-
3-ol
(3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4-(4-{2-[(1,3-
dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-
3-ol
(3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4-(4-{2-[(1,3-
dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}-3-fluoropiperidin-1-yl)oxolan-
3-ol
(3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S) or (3R,4R)(3R,4R) 4-(4-{2-[(1,3-
dimethyl-1H-pyrazol-5-yl)amino]-6-methylquinazolin-7-yl}piperidin-1-yl)-4-
methyloxolan-3-ol
(3S,4S) or (3R,4R) 4-(4-{2-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)amino]-6-
methylquinazolin-7-yl}piperidin-1-yl)-4-methyloxolan-3-ol
(3S,4S) or (3R,4R) 4-methyl-4-[4-(6-methyl-2-{[1-methyl-3-(trifluoromethyl)-1H-pyrazol-
5-yl]amino}quinazolin-7-yl)piperidin-1-yl]oxolan-3-ol
(3R,4R) 2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl)quinazoline-6-carbonitrile
(3S,4S) 2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-(oxetan-3-
yl)piperidin-4-yl)quinazoline-6-carbonitrile
2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)-7-(1-(oxetan-3-yl)piperidin-4-
yl)quinazoline-6-carbonitrile
(R)(3S,4S) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(S)(3S,4S) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(R)(3R,4R) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(S)(3R,4R) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(R)(3S,4S) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(S)(3S,4S) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(R)(3R,4R) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(S)(3R,4R) 2-((5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)amino)-7-(3-fluoro-1-
(oxetan-3-yl)piperidin-4-yl)quinazoline-6-carbonitrile
(3S,4S) or (3R,4R) 4-methyl-4-(4-(6-methyl-2-((1-methyl-5-(trifluoromethyl)-1H-pyrazol-
4-yl)amino)quinazolin-7-yl)piperidin-1-yl)tetrahydrofuran-3-ol
(R)(3S,4S)(3S,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3S,4S)(3R,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3R,4R)(3S,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3R,4R)(3R,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3S,4S)(3S,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3S,4S)(3R,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3R,4R)(3S,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(R)(3R,4R)(3R,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3S,4S)(3S,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3S,4S)(3R,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3R,4R)(3S,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3R,4R)(3R,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3S,4S)(3S,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-(3-
fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3S,4S)(3R,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3R,4R)(3S,4R) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(S)(3R,4R)(3R,4S) 6-chloro-N-(5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl)-7-
(3-fluoro-1-(4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(3S,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(1-(4-methoxy-3-
methyltetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(3R,4R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-(1-(4-methoxy-3-
methyltetrahydrofuran-3-yl)piperidin-4-yl)quinazolin-2-amine
(3S,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-fluorooxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-fluorooxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4R) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-fluorooxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-fluorooxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-methoxyoxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 6-chloro-N-(1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-7-[1-(4-methoxyoxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S)(3S,4R)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4S)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-1-
(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4R)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4S)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3R,4R)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(S)(3S,4S)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4R)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4S)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3S,4S) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4S)(3S,4S) (N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4R)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4S)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3R,4R)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(R)(3S,4S)(3R,4R) N-[1-(2,2-difluorocyclopropyl)-5-methyl-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(4-fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-fluorooxolan-
3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4R)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-fluorooxolan-
3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4S)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-fluorooxolan-
3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3S,4S) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3S,4S) or N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4R)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4S)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3R,4R)(3R,4R) N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-
fluorooxolan-3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
(3S,4S)(3R,4R)N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[3-fluoro-1-(4-fluorooxolan-
3-yl)piperidin-4-yl]-6-methylquinazolin-2-amine
6-chloro-N-(5-chloro-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-7-(1-(oxetan-3-yl)piperidin-
4-yl)quinazolin-2-amine
N-(5-bromo-1-cyclopropyl-1H-pyrazol-4-yl)-6-chloro-7-(1-(oxetan-3-yl)piperidin-4-
yl)quinazolin-2-amine
6-chloro-N-[5-chloro-1-(difluoromethyl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(S) 6-chloro-N-[5-chloro-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(R) 6-chloro-N-[5-chloro-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazol-4-yl]-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
3-(4-{6-chloro-2-[(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino]quinazolin-7-
yl}piperidin-1-yl)propanenitrile
3-(4-(6-chloro-2-((5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)thietane 1,1-dioxide
6-chloro-N-(5-chl oro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(oxetan-3-yl)piperidin-4-
yl]quinazolin-2-amine
6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-(piperidin-4-
yl)quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-[1-(3-methyloxetan-3-yl)piperidin-
4-yl]quinazolin-2-amine
2-(5-chloro-4-{[6-chloro-7-(1-methylpiperidin-4-yl)quinazolin-2-yl]amino}-1H-pyrazol-1-
yl)-2-methylpropan-1-ol
3-(4-(6-chloro-2-((5-chl oro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl)amino)quinazolin-7-
yl)piperidin-1-yl)thietane 1,1-dioxide
3-[4-(6-chloro-2-[[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]amino}quinazolin-7-
yl)piperidin-1-yl]propanenitrile
6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-(1-methylpiperidin-4-
yl)quinazolin-2-amine
6-chloro-N-[5-chloro-1-(1-methylcyclopropyl)-1H-pyrazol-4-yl]-7-[1-(3-methyloxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-(5-chloro-1-cyclopropyl-1H-pyrazol-4-yl)-7-(1-(oxetan-3-yl-2,2,4,4-
d4)piperidin-4-yl)quinazolin-2-amine
6-chloro-N-{5-chloro-1-[(3-methoxycyclobutyl)methyl]-1H-pyrazol-4-yl}-7-[1-(oxetan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[1-(oxolan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[1-(oxolan-3-yl)piperidin-4-
yl]quinazolin-2-amine
(3S,4S)(S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S)(R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R)(S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R)(R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S)(S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S)(R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R)(S) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
(3R,4R)(R) 6-chloro-N-(4-chloro-3-methyl-1,2-thiazol-5-yl)-7-[3-fluoro-1-(oxolan-3-
yl)piperidin-4-yl]quinazolin-2-amine
1-{[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]methyl}cyclopropane-1-carbonitrile
(S) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-1,1,1-trifluoro-2-methylpropan-2-ol
(R) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-1,1,1-trifluoro-2-methylpropan-2-ol
1-{[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]methyl}cyclobutan-1-ol
(S) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-1,1,1-trifluoro-2-methylpropan-2-ol
(R) 3-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-
pyrazol-1-yl]-1,1,1-trifluoro-2-methylpropan-2-ol
(R)(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3S,4S) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(R)(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(S)(3R,4R) 6-chloro-N-[5-chloro-1-(2,2-difluorocyclopropyl)-1H-pyrazol-4-yl]-7-[3-fluoro-
1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-methylquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-6-
chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3S,4S)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3S,4S) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
(3R,4R)(3R,4R) 4-[4-(2-{[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]amino}-
6-chloroquinazolin-7-yl)-3-fluoropiperidin-1-yl]oxolan-3-ol
N-[1-(bicyclo[1.1.1]pentan-1-yl)-5-chloro-1H-pyrazol-4-yl]-6-chloro-7-[1-(3-
methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
6-chloro-N-{5-chloro-1-[3-(methoxymethyl)bicyclo[1.1.1]pentan-1-yl]-1H-pyrazol-4-yl}-
7-[1-(3-methyloxetan-3-yl)piperidin-4-yl]quinazolin-2-amine
(3S,4S) 4-(4-(2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)-6-
(trifluoromethyl)quinazolin-7-yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3R,4R) 4-(4-(2-((1-cyclopropyl-5-methyl-1H-pyrazol-4-yl)amino)-6-
(trifluoromethyl)quinazolin-7-yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol
(3S,4S) 4-(4-(6-chloro-2-((3-chloro-1-methyl-1H-pyrazol-5-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol, and
3R,4R) 4-(4-(6-chloro-2-((3-chloro-1-methyl-1H-pyrazol-5-yl)amino)quinazolin-7-
yl)piperidin-1-yl)-4-methyltetrahydrofuran-3-ol.
15 . A compound according to claim 14 , or a pharmaceutically acceptable salt thereof selected from:
16 . A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
17 . A method of treating Parkinson's Disease comprising administering an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition of the same to a person in need thereof.
18 . A method for the treatment of an indication in which LRRK2 kinase is involved comprising administering to a subject in need thereof an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable composition of the same, said indication selected from:
abnormal motor symptoms associated with Parkinson's disease, non-motor symptoms associated with Parkinson's disease, Lewy body dementia, L-Dopa induced dyskinesias, Alzheimer's disease, mild cognitive impairment, the transition from mild cognitive impairment to Alzheimer's disease, tauopathy disorders characterized by hyperphosphorylation of tau, and Parkinson's disease linked to chromosome 17, neuroinflammation associated with of microglial inflammatory responses associated with multiple sclerosis, HIV-induced dementia, ALS, ischemic stroke, traumatic brain injury and spinal cord injury, lymphomas, leukemias, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, autoimmune hemolytic anemia, pure red cell aplasia, idiopathic thrombocytopenia pupura (ITP), Evans Syndrome, vasculitis, bullous skin disorder, type I diabetes mellitus, Sjogren's syndrome, Delvic's disease, inflammatory myopathies, and ankylosing spondylitis, renal cancer, breast cancer, lung cancer, prostate cancer, and acute myelogenous leukemia (AML) in subjects expressing the LRRK2 G2019S mutation, papillary renal and thyroid carcinomas in a subject in whom LRRK2 is amplified or overexpressed, Crohn's disease and leprosy.Cited by (0)
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