US12569463B2ActiveUtilityA1

Method for treating diabetes

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Assignee: OLATEC THERAPEUTICS INCPriority: Mar 25, 2020Filed: Sep 22, 2022Granted: Mar 10, 2026
Est. expiryMar 25, 2040(~13.7 yrs left)· nominal 20-yr term from priority
Inventors:DINARELLO CHARLES AMARCHETTI CARLODONATH MARC Y
A61P 3/10A61K 31/275A61P 9/04
55
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Cited by
31
References
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Claims

Abstract

The present invention is directed to a method for treating diabetes. The method comprises administering to a subject in need thereof dapansutrile, or a pharmaceutically acceptable solvate thereof, in an effective amount. Oral administration is a preferred route of administration.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method for treating diabetes, comprising the step of:
 administering to a subject suffering from diabetes an effective amount of dapansutrile, or a pharmaceutically acceptable solvate thereof.   
     
     
         2 . The method according to  claim 1 , wherein said method lowers hemoglobin A1C (HbA1c) level in the blood of the subject. 
     
     
         3 . The method according to  claim 1 , wherein said method lowers the blood glucose level in the subject. 
     
     
         4 . The method according to  claim 1 , wherein said method further prevents disease progression by treating microvascular inflammation in the subject. 
     
     
         5 . The method according to  claim 1 , wherein the subject has heart failure. 
     
     
         6 . The method according to  claim 1 , wherein dapansutrile is administered by systemic administration. 
     
     
         7 . The method according to  claim 1 , wherein dapansutrile is administered by oral administration. 
     
     
         8 . The method according to  claim 7 , where dapansutrile is administered 500-4000 mg/day.

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