Process for preparing acyl-capped 3-hydroxycarboxylic acids and their salts and esters

Abstract

The invention relates to a method for producing optionally functionalized acyl-capped (acyl-blocked) 3-hydroxybutyric acids and their salts and esters as well as to the products thus obtained and their use.

The invention claimed is: 
     
         1 . A functionalized acyl-capped 3-hydroxybutyric ester,
 wherein the functionalized acyl-capped 3-hydroxybutyric ester corresponds to general formula (III″)
   CH 3 —CH(OR 3 )—CH 2 —C(O)OR 4   (III″)
 
   wherein, in the general formula (III″), the radical R 3  represents a radical CH 3 —C(O)—CH 2 —C(O)— and the radical R 4  represents a linear or branched, saturated or mono- or polyunsaturated aliphatic C 6 -C 30 -alkyl radical.   
     
     
         2 . The functionalized acyl-capped 3-hydroxybutyric ester according to  claim 1 ,
 wherein the functionalized acyl-capped 3-hydroxybutyric ester corresponds to general formula (III″)
   CH 3 —CH(OR 3 )—CH 2 —C(O)OR 4   (III″)
 
   wherein, in the general formula (III″), the radical R 3  represents a radical CH 3 —C(O)—CH 2 —C(O)— and the radical R 4  represents a linear or branched, saturated or mono- or polyunsaturated aliphatic C 10 -C 30 -alkyl radical.   
     
     
         3 . The functionalized acyl-capped 3-hydroxybutyric ester according to  claim 1 ,
 wherein the functionalized acyl-capped 3-hydroxybutyric ester corresponds to general formula (III″)
   CH 3 —CH(OR 3 )—CH 2 —C(O)OR 4   (III″)
 
   wherein, in the general formula (III″), the radical R 3  represents a radical CH 3 —C(O)—CH 2 —C(O)— and the radical R 4  represents a linear or branched, saturated or mono- or polyunsaturated aliphatic C 10 -C 24 -alkyl radical.   
     
     
         4 . A mixture comprising at least two different functionalized acyl-capped 3-hydroxybutyric esters, as defined in  claim 1 . 
     
     
         5 . A pharmaceutical composition comprising at least one functionalized acyl-capped 3-hydroxybutyric ester, as defined in  claim 1 . 
     
     
         6 . The pharmaceutical composition according to  claim 5 ,
 wherein the pharmaceutical composition is a drug or medicament.   
     
     
         7 . A food or a food product comprising at least one functionalized acyl-capped 3-hydroxybutyric ester, as defined in  claim 1 . 
     
     
         8 . A functionalized acyl-capped 3-hydroxybutyric ester,
 wherein the functionalized acyl-capped 3-hydroxybutyric ester corresponds to general formula (III″)
   CH 3 —CH(OR 3 )—CH 2 —C(O)OR 4   (III″)
 
   wherein, in the general formula (III″), the radical R 3  represents a radical CH 3 —C(O)—CH 2 —C(O)— and the radical R 4  represents a linear or branched, saturated or mono- or polyunsaturated aliphatic C 10 -C 30 -alkyl radical.