Compositions and methods for the diagnosis and treatment of tumor

Abstract

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

What is claimed is: 
     
         1 . A method of inhibiting the growth of a cell that expresses a TAT211 polypeptide comprising the amino acid sequence of SEQ ID NO:2 or an extracellular domain thereof, said method comprising contacting said cell with an antibody comprising:
 (a) a CDR-L1 sequence of SEQ ID NO: 21;   (b) a CDR-L2 sequence of SEQ ID NO: 35;   (c) a CDR-L3 sequence of SEQ ID NO: 39;   (d) a CDR-H1 sequence of SEQ ID NO: 42;   (e) a CDR-H2 sequence of SEQ ID NO: 46; and   (f) a CDR-H3 sequence of SEQ ID NO: 61;   wherein the binding of said antibody to said TAT211 polypeptide causes an inhibition of growth of said cell.   
     
     
         2 . The method of  claim 1 , wherein said cell is an ovarian cancer cell. 
     
     
         3 . The method of  claim 1 , wherein said cell is a lung cancer cell. 
     
     
         4 . A method of therapeutically treating a mammal having a cancerous tumor comprising cells that express a TAT211 polypeptide comprising the amino acid sequence of SEQ ID NO:2 or an extracellular domain thereof, said method comprising administering to said mammal a therapeutically effective amount of an antibody comprising:
 (a) a CDR-L1 sequence of SEQ ID NO: 21;   (b) a CDR-L2 sequence of SEQ ID NO: 35;   (c) a CDR-L3 sequence of SEQ ID NO: 39;   (d) a CDR-H1 sequence of SEQ ID NO: 42;   (e) a CDR-H2 sequence of SEQ ID NO: 46; and   (f) a CDR-H3 sequence of SEQ ID NO: 61;   thereby effectively treating said mammal.   
     
     
         5 . The method of  claim 4 , wherein said cells are ovarian cancer cells. 
     
     
         6 . The method of  claim 4 , wherein said cells are lung cancer cells.