Microparticulate surgical adhesive

Abstract

Flowable polymeric microparticulate surgical adhesive formulations are provided which can be activated at the site of the repair to produce cohesive material with tissue bonding properties to adjacent tissues. The formulation may be activated at the site of repair by mechanical shear forces, heat, ultrasound, UV, or other site.

What is claimed is:  
     
         1 . A microparticulate surgical adhesive composition comprising biodegradable polymeric microparticles; which are activatable in-situ to form a high strength, cohesive material which is physiologically stable.  
     
     
         2 . An adhesive composition according to    claim 1    which is activatable in-situ by rupturing of an impermeable outer shell or coating of said microparticles to initiate a chemical reaction to form said cohesive material.  
     
     
         3 . An adhesive composition according to    claim 1    which is activatable in-situ by fusion of said microparticles to form said cohesive material.  
     
     
         4 . An adhesive composition according to    claim 1    which is activatable in-situ to form said cohesive material which comprise channels or pores for tissue integration.  
     
     
         5 . An adhesive composition according to    claim 1    comprising a flowable slurry with a physiologically compatible solvent.  
     
     
         6 . An adhesive composition according to    claim 1    which is activatable by heat.  
     
     
         7 . An adhesive composition according to    claim 1    which is activatable by ultrasound energy.  
     
     
         8 . An adhesive composition according to    claim 1    which is activatable by radio frequency or microwave energy.  
     
     
         9 . An adhesive composition according to    claim 1    which is activatable by light.  
     
     
         10 . An adhesive composition according to    claim 1    which is activatable by mechanical shear.  
     
     
         11 . An adhesive composition according to    claim 1    which further comprises a particle bridging component.  
     
     
         12 . An adhesive composition according to    claim 1    which further comprises a coating or chemical graft on the surfaces of said microparticles.  
     
     
         13 . An adhesive composition according to    claim 1    which further comprises modified chemical surfaces of the microparticles.  
     
     
         14 . An adhesive composition according to    claim 1    which further comprises growth factors or chemotactic factors.  
     
     
         15 . An adhesive composition according to    claim 1    which further comprises wound healing agents, anti-infective agents or anti-inflammatory agents.  
     
     
         16 . An adhesive composition according to    claim 1    which further comprises hollow microparticles.  
     
     
         17 . An adhesive composition according to    claim 1    which further comprises coated components which are ruptured to initiate formation of adhesive.  
     
     
         18 . An adhesive composition according to    claim 1    which further comprises collagen or gelatin microparticles.  
     
     
         19 . An adhesive composition according to    claim 1    which further comprises fibrinogen and factor XIII.  
     
     
         20 . An adhesive composition according to    claim 1    which further comprises a biodegradable thermoplastic polymer.  
     
     
         21 . A flowable adhesive composition according to    claim 1    having a solids content greater than 20 weight percent.  
     
     
         22 . A method for the securement and sealing of tissue by the site activation of a biodegradable microparticle composition comprising biodegradable polymeric microparticles, which are activatable in-situ to form a high strength, cohesive material which is physiologically stable.  
     
     
         23 . A method for the securement and sealing of tissue by the introduction of a microparticle composition comprising biodegradable polymeric microparticles, which are activatable in-situ to form a high strength, cohesive material which is physiologically stable through an apparatus which activates said composition as it is delivered to the target tissues.  
     
     
         24 . A method for the embolization of biological vessels by the introduction of a microparticle composition comprising biodegradable polymeric microparticles, which are activatable in-situ to form a high strength, cohesive material which is physiologically stable through a catheter which activates said composition as it is delivered to the target tissues.  
     
     
         25 . A method for fabricating hollow microcapsules by the introduction of limited crosslinking agent to surfaces of microspheres, quenching the crosslinking reaction, and extracting the centers of the microspheres with a solvent which swells the crosslinked shell and allows extraction of the uncrosslinked centers.