Use of hydroxymatairesinol for prevention of cancers, non-cancer, hormone dependent diseases and cardiovascular diseases by hydroxymatairesinol, and a pharmaceutical preparation, food additive and food product comprising hydroxymatairesinol

Abstract

This invention relates to methods for prevention of cancers, certain non-cancer, hormone dependent diseases and/or cardiovascular diseases in a person, based on administering of hydroxymatairesinol to said person. The invention also concerns a method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person, based on administering of hydroxymatairesinol to said person. Furthermore, this invention relates to pharmaceutical preparations, food additives and food products comprising hydroxymatairesinol.

1 . A method for prevention of a cancer, a certain non-cancer, hormone dependent disease and/or a cardiovascular disease in a person comprising administering to said person an effective amount of hydroxymatairesinol or a geometric isomer or a stereoisomer thereof.  
     
     
         2 . The method according to    claim 1    wherein said cancer is selected from the group consisting of breast cancer, prostate cancer and colon cancer.  
     
     
         3 . The method according to    claim 1    wherein said non-cancer, hormonal dependent disease is selected from the group consisting of lower urinary tract symptoms, urethral dyssynergia, bladder instability, bladder outlet obstruction, benign prostatic hyperplasia, and gynecomastia in men.  
     
     
         4 . The method according to    claim 1    wherein said cardiovascular disease is resulted from oxidized LDL in serum.  
     
     
         5 . A method for increasing the level of enterolactone or another metabolite of hydroxymatairesinol in a person's serum thereby causing prevention of a cancer or a certain non-cancer, hormone dependent disease in a person comprising administering to said person an effective amount of hydroxymatairesinol or a geometric isomer or a stereoisomer thereof.  
     
     
         6 . The method according to    claim 5    wherein said cancer is selected from the group consisting of breast cancer, prostate cancer and colon cancer.  
     
     
         7 . The method according to    claim 5    wherein said non-cancer, hormonal dependent disease is selected from the group consisting of lower urinary tract symptoms, urethral dyssynergia, benign prostatic hyperplasia, and gynecomastia in men.  
     
     
         8 . A pharmaceutical preparation comprising an effective amount of hydroxymatairesinol or a geometric isomer or a stereoisomer thereof in combination with a pharmaceutically acceptable carrier.  
     
     
         9 . A product comprising a liquid or solid material enriched with hydroxymatairesinol or a geometric isomer or a stereoisomer thereof, for use as additive to a food product.  
     
     
         10 . The product according to    claim 9    , wherein said food product is selected from the group consisting of a functional food, a nutritional supplement, a nutrient, a pharmafood, a nutraceutical, a health food, a designer food or any food product.  
     
     
         11 . The product according to    claim 9   , wherein said food product is a functional food in the form of butter, margarin, biscuits, bread, cake, candy, confectionery, yogurt or an other fermented milk product, or cereal such as muesli.  
     
     
         12 . A food product comprising an effective amount of hydroxymatairesinol or a geometric isomer or a stereoisomer thereof.  
     
     
         13 . The food product according to    claim 12    wherein said food product is selected from the group consisting of a functional food, a nutritional supplement, a nutrient, a pharmafood, a nutraceutical, a health food, a designer food or any food product.  
     
     
         14 . The food product according to    claim 13   , wherein said food product is a functional food in the form of butter, margarin, biscuits, bread, cake, candy, confectionery, yogurt or an other fermented milk product, or cereal such as muesli.  
     
     
         15 . A method for increasing the stability of a food product comprising the addition to said food product of an effective amount of hydroxymatairesinol or a geometric isomer or a stereoisomer thereof.  
     
     
         16 . The method according to    claim 15    where the increasing of food stability comprises the inhibitition of lipid, vitamin and pigment oxidations, which cause loss of nutritional value and development of off-flavors in food.