Papillomavirus cellular receptor

Abstract

The present invention provides a complex comprising a biologically active substance and a ligand that recognizes CD16.

What is claimed is:  
     
         1 . A complex comprising a pharmacologically active substance and a ligand that recognizes CD16.  
     
     
         2 . The complex of    claim 1   , further comprising an agent for tethering said pharmacologically active substance to said ligand.  
     
     
         3 . The complex of    claim 1   , further comprising a liposome.  
     
     
         4 . The complex of    claim 1   , wherein said ligand is an antibody recognizing an epitope on said CD16.  
     
     
         5 . The complex of    claim 1   , wherein said ligand is a protein comprising an external domain of a papillomavirus capsid protein.  
     
     
         6 . The complex of    claim 1   , wherein said pharmacologically active substance comprises a cytotoxic protein, a chemotherapeutic agent, or a radioactive agent.  
     
     
         7 . The complex of    claim 1   , wherein said pharmacologically active substance comprises a gene encoding a bioactive molecule.  
     
     
         8 . The complex of    claim 7   , wherein said bioactive molecule is a protein that promotes cell death.  
     
     
         9 . The complex of    claim 8   , wherein said protein is an enzyme that converts a prodrug into a cytotoxin.  
     
     
         10 . The complex of    claim 7   , wherein said bioactive molecule is an RNA having a sequence antisense to a portion of a papillomavirus gene.  
     
     
         11 . The complex of    claim 1   , comprising a chimeric protein having a first domain comprising said ligand and a second domain comprising said pharmacologically active substance.