Inhibition of IgA production

Abstract

The production of IgA is selectively inhibited by orally administering 15-deoxyspergualin or pharmacologically acceptable salts thereof, thus preventing and treating IgA-associated immunological diseases such as IgA nephropathy.

What is claimed is:  
     
         1 . A composition for oral administration to a human or an animal for selectively suppressing IgA production, containing 15-deoxyspergualin or a pharmacologically acceptable salt thereof as an active ingredient and a pharmacologically acceptable excipient or carrier suitable for oral administration.  
     
     
         2 . The composition according to    claim 1   , which is for preventing or treating IgA nephropathy.  
     
     
         3 . The composition according to    claim 1   , wherein the amount of said active ingredient, in unit dosage oral form, is an amount sufficient for suppressing IgA production without significant suppression of IgG production and/or delayed hypersensitivity.