Treatment of neuromuscular disorders and conditions with different botulinum

Abstract

A method of treating a patient suffering from a disease, disorder or condition includes the administration to the patient of a therapeutically effective amount of botulinum toxin of a selected serotype until the patient experiences loss of clinical response to the administered botulinum toxin and thereafter administering to the patient a therapeutically effective amount of another botulinum toxin of a different serotype.

What is claimed is:  
     
         1 . A method of treating a patient suffering from a neuromuscular disorder or condition, said method comprising administering to the patient a therapeutically effective amount of botulinum toxin of a selected serotype until the patient experiences loss of clinical response to the administered botulinum toxin and thereafter administering to the patient another botulinum toxin of a different serotype, said another botulinum toxin being administered in therapeutically effective amounts.  
     
     
         2 . The method according to  claim 1  wherein the botulinum toxin is type A and said another botulinum toxin is selected from the group consisting of types B, C, D and F.  
     
     
         3 . The method according to  claim 1  wherein the botulinum toxin is type E and said another botulinum toxin is selected from the group consisting of types A, B, C, D and F.  
     
     
         4 . A method of treating a patient suffering from a neuromuscular disorder or condition, said method comprising administration to the patient of a therapeutically effective amount of botulinum toxin of a selected serotype until the patient develops neutralizing antibodies and thereafter administering to the patient another botulinum toxin of a different serotype, said another botulinum toxin being administered in a therapeutically effective amount.  
     
     
         5 . The method according to  claim 4  wherein the botulinum toxin is type A and said another botulinum toxin is selected from the group consisting of types B, C, D, E and F.  
     
     
         6 . The method according to  claim 4  wherein the botulinum toxin is type B and said another botulinum toxin is selected from the group consisting of types A, C, D, E and F.  
     
     
         7 . A method of treating a patient suffering from a neuromuscular disorder or condition, said method comprising administering to the patient a therapeutically effective amount of botulinum toxin serotype A until the patient develops neutralizing antibodies and thereafter administering to the patient a therapeutically effective amount of a different serotype of botulinum toxin.  
     
     
         8 . The method according to  claim 7  wherein the different serotype comprise botulinum toxin types B, C, D, E and F.  
     
     
         9 . A method of treating a patient suffering from a neuromuscular disorder or condition, said method comprising administering to the patient a therapeutically effective amount of botulinum toxin type B until the patient develops neutralizing antibodies and thereafter administering to the patient a therapeutically effective amount of a serotype different from botulinum toxin type B.  
     
     
         10 . The method according to  claim 9  wherein the different serotype comprise botulinum toxin types A, C, D, E and F.