Methods and compositions for treatment of asthma

Abstract

The present invention comprises methods and compositions for the treatment of bronchorestrictive disorders, including asthma, in humans or animals. The methods and compositions are effective in treatment of inflammatory responses, such as those found in asthma and other related pathologies.

1 . A method of treatment of bronchorestriction in a human or animal, comprising administering an effective amount of a drug selected from the group consisting of D-propranolol, metoprolol, carvedilol, and bisoprolol and congeners and analogs, and metabolites thereof, to inhibit bronchorestriction in the human or animal.  
     
     
         2 . The method of  claim 1 , wherein the bronchorestriction is asthma.  
     
     
         3 . The method of  claim 1 , wherein the bronchorestriction is bronchial hyperresponsiveness.  
     
     
         4 . A composition for treating bronchorestriction, comprising 
 (a) a drug selected from the group consisting of D-propranolol, metoprolol, carvedilol, and bisoprolol and congeners and analogs, and metabolites thereof, admixed with    (b) a pharmaceutically acceptable carrier.    
     
     
         5 . The composition of  claim 4 , wherein the drug comprises D-propranolol.  
     
     
         6 . A dosage unit comprising an amount of drug selected from the group consisting of D-propranolol, metoprolol, carvedilol, and bisoprolol and congeners and analogs, and metabolites thereof, admixed with a carrier effective to treat asthma.  
     
     
         7 . A method of treatment of inflammation in a human or animal, comprising the administration of an effective amount of a drug selected from the group consisting of D-propranolol, metoprolol, carvedilol, and bisoprolol and congeners and analogs, and metabolites thereof, to inhibit inflammation in the human or animal.