Novel hepatic disorder suppressant

Abstract

A hepatic disorder suppressant comprising extracts having hepatic disorder suppressing effect as effective ingredients, wherein the extracts is obtained by extracting an avocado plant and/or a processed product thereof with an organic solvent is disclosed.

What is claimed is:  
     
         1 . A hepatic disorder suppressant comprising extracts having hepatic disorder suppressing effect as effective ingredients, wherein the extracts is obtained by extracting an avocado plant and/or a processed product thereof with an organic solvent.  
     
     
         2 . A hepatic disorder suppressant comprising, a substance having hepatic disorder suppressing effect, as an effective ingredient, wherein the substance is obtained by steps 1) extracting an avocado plant and/or a processed product thereof with an organic solvent, and 2) fractionating the extract by chromatography, wherein the substance has an Rf value between 0.19 and 0.25 when thin-layer chromatography is carried out on a Silica Gel 60 produced by Merck & Co., Inc. with an organic solvent of 4:1 n-hexane/ethyl acetate as the developing solvent.  
     
     
         3 . A hepatic disorder suppressant according to  claim 1  or  2 , wherein the organic solvent is a nonpolar organic solvent.  
     
     
         4 . A hepatic disorder suppressant according to  claim 1  or  2 , wherein the organic solvent is one or more selected from the group consisting of n-hexane, cyclohexane, benzene and carbon tetrachloride.  
     
     
         5 . A hepatic disorder suppressant according to  claim 1  or  2 , wherein the organic solvent is n-hexane.  
     
     
         6 . A hepatic disorder suppressant according to  claim 2 , wherein the chromatography is carried out by the use of a silica gel column.  
     
     
         7 . A pharmaceutical composition for suppressing hepatic disorders comprising a hepatic disorder suppressant according to  claim 1  or  2 .  
     
     
         8 . A food composition for suppressing hepatic disorders comprising a hepatic disorder suppressant according to  claim 1  or  2 .  
     
     
         9 . A linoleic acid derivative represented by the following formula (1).  
       
         
           
           
               
               
           
         
       
     
     
         10 . A linoleic acid derivative represented by the following formula (2).  
       
         
           
           
               
               
           
         
       
     
     
         11 . An oleic acid derivative represented by the following formula (3).  
       
         
           
           
               
               
           
         
       
     
     
         12 . A hepatic disorder suppressant comprising a compound according to any of  claims 9  to  11 , or a linoleic acid derivative represented by the following formula (4) or (5) as an effective ingredient.