Process for the diagnostic assessment and monitoring, as well as medicaments for the therapy of states of shock in humans

Abstract

Patients suffering from shock illness exhibit increased levels of cyclophilins. Accordingly, methods for diagnosing, monitoring and treating shock patients are disclosed. Medicaments for therapeutically treating patients suffering from shock illness are also provided, for example, Cyclosporin A.

1 . Process for the detection of states of shock and for the therapy control of shock patients, characterised in that the concentration of cyclophilines in the blood of the patients is determined with the help of 
 a) enzymological methods,    b) immunological detection methods with the help of specific antibody    c) peptide-chemical processes,    d) radiochemical methods    and serves for the evaluation of the degree of seriousness of the shock.    
     
     
         2 . Process according to  claim 1 , characterised in that there is used 
 a) as enzymological method, the rotamase activity measurement or,    b) as immunological detection method, radio-immunoassays, ELISA enzyme linked immuno-sorben assay or    c) as peptide-chemical process, the affinity chromatography or    d) the binding of radio-active cyclosporin under special physicochemical reaction conditions.    
     
     
         3 . The use of medicaments, biological active materials and physicochemical methods which reduce the concentration of the active cyclophilines in the blood of shock patients, for the therapy of the shock, especially of the septic shock, of the post-operative shock and of the toxic shock.  
     
     
         4 . Use according to  claim 3 , characterised in that one employs 
 a) cyclosporins or cyclosporin-related, cyclophiline-inactivating active materials,    b) pharmaceuticals with inactivating properties binding specifically or non-specifically to cyclophilines,    c) biological inactivators of the cyclophilines, anti-bodies, antibody fragments, cyclophiline-destroying enzymes,    d) all forms of blood washing insofar as they are suitable to eliminate cyclophilines or cyclophiline-containing blood fractions.