Compositions and method for stimulating hair growth

Abstract

A method for regulation of hair growth in an adult mammal, in which a trichogenic composition is applied to the skin. Also disclosed are methods for inducing skin differentiation and stimulating hair growth, wherein a formulation of a trichogenic composition is applied to the skin.

We claim:  
     
         1 . A method for promoting hair growth in skin of a mammal, inducing hair follicle differentiation in said skin, inducing a shift in hair growth cycle from telogen to anagen in said skin, increasing the rate of hair shaft elongation in said skin, or improving the skin of a mammal, comprising the step of: 
 applying to the skin of said mammal a composition which comprises:    i) from 0.0001 to 99% by weight of a cyanocarboxylic acid derivative; and    ii) from 1 to 99.999% by weight of a vehicle for component i).    
     
     
         2 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative has the formula:  
       
         
           
           
               
               
           
         
       
       wherein R is an ester, an amide, an alkyl amide, a dialkyl amide, an-alkoxyalkylamide, an anhydride, a halide, a nitrile or an amino group; and R 2  is C 1 -C 10  alkyl, cycloalkyl, alkenyl, alkoxyalkenyl, alkynyl, aryl, alkaryl or aralkyl.  
     
     
         3 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative has the formula:  
       
         
           
           
               
               
           
         
       
       wherein R is an ester of C 1 -C 20  alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, hydroxyalkyl, or mono- or poly- alkoxyalkyl, an alkyl amide of C 1 -C 20 , a dialkyl amide of C 1 -C 20  an alkoxyalkylamide, an anhydride of C 1 -C 20 , a halide, a nitrile, or an amino group; and R 2  is C 1 -C 10  alkyl, cycloalkyl, alkenyl, alkoxyalkenyl, alkynyl, aryl, alkaryl, aralkyl, or H.  
     
     
         4 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative has the formula:  
       
         
           
           
               
               
           
         
       
       wherein R is C 1 -C 20  alkyl, cycloalkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, or mono- or poly- alkoxyalkyl; and R 2  is C 1 -C 10  alkyl, cycloalkyl, alkenyl, alkoxyalkenyl, alkynyl, aryl, alkaryl, aralkyl, or H.  
     
     
         5 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative has the formula:  
       
         
           
           
               
               
           
         
       
     
     
         6 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative has the formula:  
       
         
           
           
               
               
           
         
       
     
     
         7 . The method according to  claim 1 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         8 . The method of  claim 2 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         9 . The method of  claim 3 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         10 . The method of  claim 4 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         11 . The method of  claim 5 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         12 . The method of  claim 6 , wherein said applying step comprises applying a trichogenically effective amount of said cyanocarboxylic acid derivative to said skin.  
     
     
         13 . The method of  claim 1 , wherein said applying step comprises applying a physiologically effective composition to said skin.  
     
     
         14 . The method of  claim 2 , wherein said applying step comprises applying a physiologically effective composition to said skin.  
     
     
         15 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative is selected from: 
 ethoxyethyl 2-cyanoacrylate    butoxyethyl 2-cyanoacrylate    n-butyl 2-cyanoacrylate    isobutyl 2-cyanoacrylate    n-propyl 2-cyanoacrylate    isopropyl 2-cyanoacrylate    n-hexyl 2-cyanoacrylate    isohexyl 2-cyanoacrylate    cyclohexyl 2-cyanoacrylate    benzyl 2-cyanoacrylate    glycerol 2-cyanoacrylate    ethoxybutyl 2-cyanoacrylate    n-pentyl 2-cyanoacrylate    isopentyl 2-cyanoacrylate    n-heptyl 2-cyanoacrylate    isoheptyl 2-cyanoacrylate    n-octyl 2-cyanoacrylate    isooctyl 2-cyanoacrylate    n-nonyl 2-cyanoacrylate    isononyl 2-cyanoacrylate    n-decyl 2-cyanoacrylate    isodecyl 2-cyanoacrylate    n-butyl 2-cyano-3-methoxyacrylate    isobutyl 2-cyano-3-methoxyacrylate    n-butyl 2-cyano-3-phenylacrylate    isobutyl 2-cyano-3-phenylacrylate    n-butyl-2-cyano-2-butenoate    isobutyl-2-cyano-2-butenoate    n-butyl-2-cyano-2-pentenoate    isobutyl-2-cyano-2-pentenoate    n-butyl-2-cyano-2-hexenoate    isobutyl-2-cyano-2-hexenoate    n-butyl-2-cyano-2-heptenoate    isobutyl-2-cyano-2-heptenoate    n-butyl-2-cyano-2-octenoate    isobutyl-2-cyano-2-octenoate    n-butyl-2-cyano-2-nonenoate    isobutyl-2-cyano-2-nonenoate    n-butyl-2-cyano-2-decenoate    isobutyl-2-cyano-2-decenoate    N-propyl-2-cyanoacrylamide    N-butyl-2-cyanoacrylamide    N-pentyl-2-cyanoacrylamide    N-hexyl-2-cyanoacrylamide    N-heptyl-2-cyanoacrylamide    N-octyl-2-cyanoacrylamide    N-nonyl-2-cyanoacrylamide    N-decyl-2-cyanoacrylamide    N-benzyl-2-cyanoacrylamide    N-cyclohexyl-2-cyanoacrylamide    N-ethoxyethyl-2-cyanoacrylamide    N-ethoxypropyl-2-cyanoacrylamide    N-ethoxybutyl-2-cyanoacrylamide    N-ethoxypentyl-2-cyanoacrylamide    N-ethoxyhexyl-2-cyanoacrylamide    N-ethoxyheptyl-2-cyanoacrylamide    N-ethoxyoctyl-2-cyanoacrylamide    N-ethoxynonyl-2-cyanoacrylamide    N-ethoxydecyl-2-cyanoacrylamide    N-propoxyethyl-2-cyanoacrylamide    N-propoxypropyl-2-cyanoacrylamide    N-propoxybutyl-2-cyanoacrylamide    N-propoxypentyl-2-cyanoacrylamide    N-propoxyhexyl-2-cyanoacrylamide    N-propoxyheptyl-2-cyanoacrylamide    N-propoxyoctyl-2-cyanoacrylamide    N-propoxynonyl-2-cyanoacrylamide    N-propoxydecyl-2-cyanoacrylamide    N-butoxyethyl-2-cyanoacrylamide    N-butoxypropyl-2-cyanoacrylamide    N-butoxybutyl-2-cyanoacrylamide    N-butoxypentyl-2-cyanoacrylamide    N-butoxyhexyl-2-cyanoacrylamide    N-butoxyheptyl-2-cyanoacrylamide    N-butoxyoctyl-2-cyanoacrylamide    N-butoxynonyl-2-cyanoacrylamide    N-butoxydecyl-2-cyanoacrylamide.    
     
     
         16 . A composition for promoting hair growth in the skin of a mammal, inducing hair follicle differentiation in said skin, inducing a shift in hair growth cycle from telogen to anagen in said skin, increasing the rate of hair shaft elongation in said skin, or improving the skin of a mammal, consisting essentially of:  
       
         
           
           
               
               
           
         
       
     
     
         17 . The method of  claim 1 , wherein said applying step comprises applying one of n-butyl cyanoacrylate and isobutyl cyanoacrylate to said skin.  
     
     
         18 . The method of  claim 1 , wherein said applying step comprises one of: topically applying said composition to the skin, applying said composition via a dermal patch, applying said composition via intradermal injection, and subcutaneously injecting said composition.  
     
     
         19 . The method of  claim 17 , wherein said applying step comprises one of: topically applying said one of n-butyl cyanoacrylate and isobutyl cyanoacrylate to the skin, applying said composition via a dermal patch, applying said composition via intradermal injection, and subcutaneously injecting said composition.  
     
     
         20 . The method of  claim 1 , wherein said applying step comprises applying said composition to the skin of a human.  
     
     
         21 . The method of  claim 1 , wherein said applying step comprises applying said composition to the skin of a mammal, wherein said skin is no longer attached to said mammal.  
     
     
         22 . The method of  claim 1 , wherein said applying step comprises applying said composition to the skin of a sheep.  
     
     
         23 . The method of  claim 1 , wherein said applying step comprises applying said composition to the skin of a mouse.  
     
     
         24 . The method according to  claim 1 , wherein said cyanocarboxylic acid derivative is at least one of the following formulas:  
       
         
           
           
               
               
           
         
       
     
     
         25 . The method of  claim 24 , wherein said applying step comprises applying said composition to the skin of a human.  
     
     
         26 . The method of  claim 24 , wherein said applying step comprises applying said composition to the skin of a sheep.  
     
     
         27 . The method of  claim 1 , wherein said applying step comprises applying said composition containing at least 25% of said component i) to said skin.  
     
     
         28 . The method of  claim 24 , wherein said applying step comprises applying said composition containing at least 25% of said component i) to said skin.  
     
     
         29 . The method of  claim 24 , wherein said applying step comprises applying said composition containing at least 50% of said component i) to said skin.  
     
     
         30 . The method of  claim 1 , wherein said applying step comprises: topically spraying said composition to the skin.  
     
     
         31 . The method of  claim 1 , wherein said applying step comprises applying said composition to the skin of an animal from which fur is to be obtained.  
     
     
         32 . The method of  claim 24 , wherein said applying step comprises applying said composition to the skin of an animal from which fur is to be obtained.